Publications by authors named "Nicholas D Gansemer"

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Mucociliary clearance is impaired in small airways of cystic fibrosis pigs.
Carley G Stewart, Brieanna M Hilkin, Nicholas D Gansemer, Ryan J Adam, David W Dick

Am J Physiol Lung Cell Mol Physiol· October 2024

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Amphiphilic shuttle peptide delivers base editor ribonucleoprotein to correct the CFTR R553X mutation in well-differentiated airway epithelial cells.
Katarina Kulhankova, Anna X Cheng, Soumba Traore, Maud Auger, Mia Pelletier, Nicholas D Gansemer

Nucleic Acids Res· October 2024

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IL-13 induces loss of CFTR in ionocytes and reduces airway epithelial fluid absorption.
Guillermo S Romano Ibarra, Lei Lei, Wenjie Yu, Andrew L Thurman, Nicholas D Gansemer

J Clin Invest· September 2024

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Development and Initial Characterization of Pigs with Mutations and Primary Ciliary Dyskinesia.
Mahmoud A Abou Alaiwa, Brie M Hilkin, Margaret P Price, Nicholas D Gansemer, Michael R Rector

bioRxiv· August 2024

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Arteriovenous metabolomics in pigs reveals CFTR regulation of metabolism in multiple organs.
Hosung Bae, Bo Ram Kim, Sunhee Jung, Johnny Le, Dana van der Heide, Nicholas D Gansemer

J Clin Invest· May 2024

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Mucociliary Clearance is Impaired in Small Airways of Cystic Fibrosis Pigs.
Carley G Stewart, Brieanna M Hilkin, Nicholas D Gansemer, David W Dick, John J Sunderland

bioRxiv· May 2024

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Tromethamine improves mucociliary clearance in cystic fibrosis pigs.
Jamison J Ash, Brieanna M Hilkin, Nicholas D Gansemer, Eric A Hoffman, Joseph Zabner

Physiol Rep· September 2022

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Elastic mucus strands impair mucociliary clearance in cystic fibrosis pigs.
Maria I Pino-Argumedo, Anthony J Fischer, Brieanna M Hilkin, Nicholas D Gansemer, Patrick D Allen

Proc Natl Acad Sci U S A· March 2022

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Lack of airway submucosal glands impairs respiratory host defenses.
Lynda S Ostedgaard, Margaret P Price, Kristin M Whitworth, Mahmoud H Abou Alaiwa, Anthony J Fischer, Nicholas D Gansemer

Elife· October 2020

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HSP90 inhibitor geldanamycin reverts IL-13- and IL-17-induced airway goblet cell metaplasia.
Alejandro A Pezzulo, Rosarie A Tudas, Carley G Stewart, Luis G Vargas Buonfiglio, Brian D Lindsay, Nicholas D Gansemer

J Clin Invest· February 2019

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Mucus strands from submucosal glands initiate mucociliary transport of large particles.
Anthony J Fischer, Maria I Pino-Argumedo, Brieanna M Hilkin, Cullen R Shanrock, Nicholas D Gansemer

JCI Insight· January 2019

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Postnatal airway growth in cystic fibrosis piglets.
Ryan J Adam, Mahmoud H Abou Alaiwa, Drake C Bouzek, Daniel P Cook, Nicholas D Gansemer

J Appl Physiol (1985)· September 2017

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CF airway smooth muscle transcriptome reveals a role for PYK2.
Daniel P Cook, Ryan J Adam, Keyan Zarei, Benjamin Deonovic, Mallory R Stroik, Nicholas D Gansemer

JCI Insight· September 2017

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Gel-forming mucins form distinct morphologic structures in airways.
Lynda S Ostedgaard, Thomas O Moninger, James D McMenimen, Nicholas M Sawin, Connor P Parker, Nicholas D Gansemer

Proc Natl Acad Sci U S A· June 2017

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gene transfer with AAV improves early cystic fibrosis pig phenotypes.
Benjamin Steines, David D Dickey, Jamie Bergen, Katherine Jda Excoffon, John R Weinstein, Nicholas D Gansemer

JCI Insight· September 2016

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Repurposing tromethamine as inhaled therapy to treat CF airway disease.
Mahmoud H Abou Alaiwa, Janice L Launspach, Kelsey A Sheets, Jade A Rivera, Nicholas D Gansemer

JCI Insight· June 2016

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Cystic Fibrosis Transmembrane Conductance Regulator in Sarcoplasmic Reticulum of Airway Smooth Muscle. Implications for Airway Contractility.
Daniel P Cook, Michael V Rector, Drake C Bouzek, Andrew S Michalski, Nicholas D Gansemer

Am J Respir Crit Care Med· February 2016

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pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37.
Mahmoud H Abou Alaiwa, Leah R Reznikov, Nicholas D Gansemer, Kelsey A Sheets, Alexander R Horswill

Proc Natl Acad Sci U S A· December 2014

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Air trapping and airflow obstruction in newborn cystic fibrosis piglets.
Ryan J Adam, Andrew S Michalski, Christian Bauer, Mahmoud H Abou Alaiwa, Thomas J Gross, Nicholas D Gansemer

Am J Respir Crit Care Med· December 2013

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Abundant DNase I-sensitive bacterial DNA in healthy porcine lungs and its implications for the lung microbiome.
Alejandro A Pezzulo, Patrick H Kelly, Boulos S Nassar, Cedric J Rutland, Nicholas D Gansemer

Appl Environ Microbiol· October 2013

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Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs.
David A Stoltz, Tatiana Rokhlina, Sarah E Ernst, Alejandro A Pezzulo, Lynda S Ostedgaard, Nicholas D Gansemer

J Clin Invest· June 2013

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Adenoviral gene transfer corrects the ion transport defect in the sinus epithelia of a porcine CF model.
Andrea E Potash, Tanner J Wallen, Philip H Karp, Sarah Ernst, Thomas O Moninger, Nicholas D Gansemer

Mol Ther· May 2013

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Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis.
Eugene H Chang, Alejandro A Pezzulo, David K Meyerholz, Andrea E Potash, Tanner J Wallen, Nicholas D Gansemer

Laryngoscope· September 2012

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Coxsackievirus and adenovirus receptor (CAR) mediates trafficking of acid sensing ion channel 3 (ASIC3) via PSD-95.
Katherine J D A Excoffon, Abimbola O Kolawole, Nobuyoshi Kusama, Nicholas D Gansemer, Priyanka Sharma

Biochem Biophys Res Commun· August 2012

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CFTR is required for maximal transepithelial liquid transport in pig alveolar epithelia.
Xiaopeng Li, Alejandro P Comellas, Philip H Karp, Sarah E Ernst, Thomas O Moninger, Nicholas D Gansemer

Am J Physiol Lung Cell Mol Physiol· July 2012

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