Publications by authors named "Nicholas Denomme"

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A chemogenetic ligand-receptor pair for voltage-gated sodium channel subtype-selective inhibition.
Elizabeth R Park, Nicholas Denomme, Holly S Hajare, J Du Bois

bioRxiv· November 2025

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Neuromodulation of voltage-gated sodium channels by Gβ1γ2 subunits: Implications for GNB1-linked encephalopathy.
Nicholas Denomme, Samantha L Hodges, Luis Lopez-Santiago, Yukun Yuan, Julie M Ziobro

Neurobiol Dis· September 2025

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Ataxia and cerebellar hypoexcitability in a mouse model of SCN1B-linked Dravet syndrome.
Yukun Yuan, Heather A O'Malley, Jesse J Winters, Alfonso Lavado, Nicholas S Denomme

JCI Insight· September 2025

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Cholinergic modulation of dopamine release drives effortful behavior.
Gavin C Touponse, Matthew B Pomrenze, Teema Yassine, Viraj Mehta, Nicholas Denomme

bioRxiv· June 2025

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Ketamine, the First Associative Anesthetic? Some Considerations on Classifying Psychedelics, Entactogens, and Dissociatives.
Nicholas Denomme, Boris D Heifets

Am J Psychiatry· September 2024

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-(4-Bromo-2,5-Dimethoxyphenethyl)-6-(4-Phenylbutoxy)Hexan-1-Amine (XOB): A Novel Phenylalkylamine Antagonist of Serotonin 2A Receptors and Voltage-Gated Sodium Channels.
Nicholas Denomme, Ciria C Hernandez, Hailey A Bock, Rachel F Ohana, Shreeya Bakshi

Mol Pharmacol· July 2024

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Antisense oligonucleotides restore excitability, GABA signalling and sodium current density in a Dravet syndrome model.
Yukun Yuan, Luis Lopez-Santiago, Nicholas Denomme, Chunling Chen, Heather A O'Malley

Brain· April 2024

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Heterogeneity of voltage gated sodium current density between neurons decorrelates spiking and suppresses network synchronization in Scn1b null mouse models.
Jacob M Hull, Nicholas Denomme, Yukun Yuan, Victoria Booth, Lori L Isom

Sci Rep· June 2023

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Excitatory and inhibitory neuron defects in a mouse model of Scn1b-linked EIEE52.
Jacob M Hull, Heather A O'Malley, Chunling Chen, Yukun Yuan, Nicholas Denomme

Ann Clin Transl Neurol· November 2020

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The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Na1.1 in addition to Na1.6.
Nicholas Denomme, April L Lukowski, Jacob M Hull, Margaret B Jameson, Alexandra A Bouza

Neurosci Lett· April 2020

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The Domino Effect: Ed Domino's early studies of Psychoactive Drugs.
Nicholas Denomme

J Psychoactive Drugs· October 2019

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Role of Voltage-Gated Sodium Channels in the Mechanism of Ether-Induced Unconsciousness.
Nicholas Denomme, Jacob M Hull, George A Mashour

Pharmacol Rev· October 2019

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Biocatalytic Detoxification of Paralytic Shellfish Toxins.
April L Lukowski, Nicholas Denomme, Meagan E Hinze, Sherwood Hall, Lori L Isom

ACS Chem Biol· May 2019

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