Publications by authors named "Nicholas Kirkby"

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Impact of Type 1 Diabetes on Endothelial Cells Derived From Living Donors.
Isra Marei, Maria Vinokurova, Li Qiucheng, Lasse Nyhegn, Eric Dubuis, Nicholas S Kirkby

FASEB Bioadv· November 2025

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Fibroblast Cyclo-Oxygenase-2 Associated With the Kidney Restrains Methylarginines and Thrombosis: Relevance to Cardiovascular Side Effects of Non-Steroidal Anti-Inflammatory Drugs.
Maria E Lopes-Pires, Fisnik Shala, Ugo Soffientini, Neringa Cypaite, Maria Vinokurova, Nicholas S Kirkby

FASEB J· August 2025

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Icosapent ethyl reduces arterial thrombosis by inhibition of cyclooxygenase-1-induced platelet reactivity.
Philipp Mourikis, Marcel Benkhoff, Laura Wildeis, Maike Barcik, Carolin Helten, Nicholas Kirkby

Sci Transl Med· May 2025

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Vascular and inflammatory biomarkers of cardiovascular events in non-steroidal anti-inflammatory drug users.
Ricky Vaja, Plinio Ferreira, Laura Portas, Blerina Ahmetaj-Shala, Neringa Cypaite, Nicholas S Kirkby

Eur Heart J Open· November 2024

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L-arginine supplementation protects against thrombosis and renal dysfunction in mice treated with the cyclooxygenase-2 inhibitor parecoxib.
Ricky Vaja, Maria Lopes-Pires, Fisnik Shala, Neringa Cypaite, Maria Vinokurova, Nicholas S Kirkby

J Thromb Haemost· June 2024

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Author Correction: Development of a novel UHPLC-MS/MS-based platform to quantify amines, amino acids and methylarginines for applications in human disease phenotyping.
Blerina Ahmetaj-Shala, Michael Olanipekun, Abel Tesfai, Niall MacCallum, Nicholas S Kirkby

Sci Rep· May 2024

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Widening the Prostacyclin Paradigm: Tissue Fibroblasts Are a Critical Site of Production and Antithrombotic Protection.
Maria Vinokurova, Maria Elisa Lopes-Pires, Neringa Cypaite, Fisnik Shala, Paul C Armstrong, Nicholas S Kirkby

Arterioscler Thromb Vasc Biol· January 2024

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Pulmonary Hypertension-Associated Right Ventricular Cardiomyocyte Remodelling Reduces Treprostinil Function.
Aleksandra Judina, Marili Niglas, Vladislav Leonov, Nicholas S Kirkby, Ivan Diakonov

Cells· December 2023

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Renal Function Underpins the Cyclooxygenase-2: Asymmetric Dimethylarginine Axis in Mouse and Man.
Plinio Ferreira, Ricky Vaja, Maria Lopes-Pires, Marilena Crescente, He Yu, Nicholas S Kirkby

Kidney Int Rep· June 2023

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Temporal in vivo platelet labeling in mice reveals age-dependent receptor expression and conservation of specific mRNAs.
Paul C Armstrong, Harriet E Allan, Nicholas S Kirkby, Clemens Gutmann, Abhishek Joshi

Blood Adv· December 2022

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Platelet inhibition by P2Y antagonists is potentiated by adenosine signalling activators.
Chih-Chin Shih, Melissa V Chan, Nicholas S Kirkby, Ivana Vojnovic, Jane A Mitchell

Br J Pharmacol· December 2021

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Activation and Contraction of Human "Vascular" Smooth Muscle Cells Grown From Circulating Blood Progenitors.
Blerina Ahmetaj-Shala, Isra Marei, Ryota Kawai, Stephen Rothery, Charis Pericleous, Nicholas S Kirkby

Front Cell Dev Biol· August 2021

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The COVID-19 ibuprofen controversy: A systematic review of NSAIDs in adult acute lower respiratory tract infections.
Ricky Vaja, Jeffrey Shi Kai Chan, Plinio Ferreira, Amer Harky, Luke J Rogers, Nicholas S Kirkby

Br J Clin Pharmacol· March 2021

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Endothelial cyclooxygenase-1 paradoxically drives local vasoconstriction and atherogenesis despite underpinning prostacyclin generation.
Jane A Mitchell, Fisnik Shala, Maria Elisa Lopes Pires, Rachel Y Loy, Andrew Ravendren, Nicholas S Kirkby

Sci Adv· March 2021

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Studies on metal-organic framework (MOF) nanomedicine preparations of sildenafil for the future treatment of pulmonary arterial hypertension.
Nura A Mohamed, Haissam Abou-Saleh, Yu Kameno, Isra Marei, Gilberto de Nucci, Nicholas S Kirkby

Sci Rep· February 2021

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Cyclooxygenases and the cardiovascular system.
Jane A Mitchell, Nicholas S Kirkby, Blerina Ahmetaj-Shala, Paul C Armstrong, Marilena Crescente

Pharmacol Ther· January 2021

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Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells.
Blerina Ahmetaj-Shala, Ricky Vaja, Santosh S Atanur, Peter M George, Nicholas S Kirkby

JACC Basic Transl Sci· November 2020

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Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis.
Nicholas S Kirkby, Joan Raouf, Blerina Ahmetaj-Shala, Bin Liu, Sarah I Mazi

Cardiovasc Res· October 2020

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Profiling the eicosanoid networks that underlie the anti- and pro-thrombotic effects of aspirin.
Marilena Crescente, Paul C Armstrong, Nicholas S Kirkby, Matthew L Edin, Melissa V Chan

FASEB J· August 2020

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Combination of cyclic nucleotide modulators with P2Y receptor antagonists as anti-platelet therapy.
Paul C Armstrong, Plinio M Ferreira, Melissa V Chan, Martina H Lundberg Slingsby, Marilena Crescente, Nicholas S Kirkby

J Thromb Haemost· July 2020

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A bioassay system of autologous human endothelial, smooth muscle cells, and leukocytes for use in drug discovery, phenotyping, and tissue engineering.
Blerina Ahmetaj-Shala, Ryota Kawai, Isra Marei, Zacharoula Nikolakopoulou, Chih-Chin Shih, Nicholas S Kirkby

FASEB J· January 2020

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Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox.
Jane A Mitchell, Fisnik Shala, Youssef Elghazouli, Timothy D Warner, Carles Gaston-Massuet, Nicholas S Kirkby

Circ Res· October 2019

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Imaging of Tissue-Specific and Temporal Activation of GPCR Signaling Using DREADD Knock-In Mice.
Dmitry Akhmedov, Nicholas S Kirkby, Jane A Mitchell, Rebecca Berdeaux

Methods Mol Biol· August 2019

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Development of a novel UHPLC-MS/MS-based platform to quantify amines, amino acids and methylarginines for applications in human disease phenotyping.
Blerina Ahmetaj-Shala, Michael Olanipekun, Abel Tesfai, Niall MacCallum, Nicholas S Kirkby

Sci Rep· September 2018

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Letter by Mitchell et al Regarding Article, "Urinary Prostaglandin Metabolites: An Incomplete Reckoning and a Flush to Judgment".
Jane A Mitchell, Rebecca B Knowles, Nicholas S Kirkby, Daniel M Reed, Matthew L Edin

Circ Res· May 2018

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