Publications by authors named "Nicholas Morrell"

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BMP9 knockout impairs pulmonary vessel muscularisation and confers aberrant tamoxifen sensitivity.
Benjamin J Dunmore, Stephen Moore, Rowena J Jones, Joshua Hodgson, Kathryn Auckland, Nicholas W Morrell

Angiogenesis· November 2025

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Therapeutic potential of allosteric HECT E3 ligase inhibition.
Alexander M K Rothman, Amir Florentin, Florence Zink, Catherine Quigley, Olivier Bonneau, Nicholas W Morrell

Cell· May 2025

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Exploring Diagnostic and Therapeutic Odyssey in Pulmonary Arterial Hypertension: Insights from In-Depth Semi-Structured Interviews.
Emilia M Swietlik, Michaela Fay, Nicholas W Morrell

Respiration· April 2025

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Correction to: Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension.
Jason Hong, Lejla Medzikovic, Wasila Sun, Brenda Wong, Grégoire Ruffenach, Nicholas W Morrell

Circulation· April 2025

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Activin-A Regulates Bone Morphogenetic Protein Signaling in Pulmonary Endothelial Cells Without Affecting Bone Morphogenetic Protein Type-II Receptor Expression.
Benjamin J Dunmore, Nobuhiro Kikuchi, Wei Li, Paul D Upton, Nicholas W Morrell

Pulm Circ· April 2025

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Navigating family dynamics and ethical considerations in genetic diagnosis of pulmonary arterial hypertension: insights from in-depth semi-structured interviews.
Emilia M Swietlik, Michaela Fay, Nicholas W Morrell

ERJ Open Res· March 2025

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Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension.
Jason Hong, Lejla Medzikovic, Wasila Sun, Brenda Wong, Grégoire Ruffenach, Nicholas W Morrell

Circulation· October 2024

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Reply to the letter to the editor entitled "Bridging the species divide: The limits of rat models in capturing human PVOD mechanisms" by Perros F. et al.
Amit Prabhakar, Rahul Kumar, Meetu Wadhwa, Rubin M Tuder, Nicholas W Morrell

Pulm Circ· October 2024

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Fluorinated perhexiline derivative attenuates vascular proliferation in pulmonary arterial hypertension smooth muscle cells.
Kayleigh Griffiths, Roger J Grand, Ian Horan, Michelangelo Certo, Ross C Keeler, Nicholas W Morrell

Vascul Pharmacol· September 2024

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Functional validation of EIF2AK4 (GCN2) missense variants associated with pulmonary arterial hypertension.
Giulia Emanuelli, JiaYi Zhu, Wei Li, Nicholas W Morrell, Stefan J Marciniak

Hum Mol Genet· August 2024

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Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response.
Amit Prabhakar, Rahul Kumar, Meetu Wadhwa, Prajakta Ghatpande, Jingkun Zhang, Nicholas W Morrell

Nat Cardiovasc Res· July 2024

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Shared and Distinct Genomics of Chronic Thromboembolic Pulmonary Hypertension and Pulmonary Embolism.
James Liley, Michael Newnham, Marta Bleda, Katherine Bunclark, William Auger, Nicholas Morrell

Am J Respir Crit Care Med· June 2024

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SEMA3G regulates BMP9 inhibition of VEGF-mediated migration and network formation in pulmonary endothelial cells.
Sarah L Mirza, Paul D Upton, Joshua Hodgson, Stefan Gräf, Nicholas W Morrell

Vascul Pharmacol· June 2024

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ATP13A3 variants promote pulmonary arterial hypertension by disrupting polyamine transport.
Bin Liu, Mujahid Azfar, Ekaterina Legchenko, James A West, Shaun Martin, Nicholas W Morrell

Cardiovasc Res· May 2024

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Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension.
Anna Ulrich, Yukyee Wu, Harmen Draisma, John Wharton, Emilia M Swietlik, Nicholas W Morrell

Nat Commun· January 2024

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Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension.
Yi-Yin Tai, Qiujun Yu, Ying Tang, Wei Sun, Neil J Kelly, Nicholas W Morrell

Sci Transl Med· January 2024

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Understanding what drives genetic study participation: Perspectives of patients, carers, and relatives.
Emilia M Swietlik, Michaela Fay, Nicholas W Morrell

Pulm Circ· January 2024

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Unlocking the potential of genetic research in pulmonary arterial hypertension: Insights from clinicians, researchers, and study team.
Emilia M Swietlik, Michaela Fay, Nicholas W Morrell

Pulm Circ· January 2024

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Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response.
Amit Prabhakar, Rahul Kumar, Meetu Wadhwa, Prajakta Ghatpande, Jingkun Zhang, Nicholas W Morrell

bioRxiv· November 2023

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Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension.
Rachel Walters, Eleni Vasilaki, Jurjan Aman, Chien-Nien Chen, Yukyee Wu, Nicholas W Morrell

Circulation· May 2023

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High concentrations of soluble endoglin can inhibit BMP9 signaling in non-endothelial cells.
Clara Andersson-Rusch, Bin Liu, Ingrid Quist-Løkken, Paul D Upton, Oddrun Elise Olsen, Nicholas W Morrell

Sci Rep· April 2023

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Angiopoietin 2 and hsCRP are associated with pulmonary hemodynamics and long-term mortality respectively in CTEPH-Results from a prospective discovery and validation biomarker study.
Charaka M Hadinnapola, Mark Southwood, Jules Hernández-Sánchez, Katherine Bunclark, Michael Newnham, Nicholas W Morrell

J Heart Lung Transplant· March 2023

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Integrative Multiomics to Dissect the Lung Transcriptional Landscape of Pulmonary Arterial Hypertension.
Jason Hong, Brenda Wong, Christopher J Rhodes, Zeyneb Kurt, Tae-Hwi Schwantes-An, Nicholas W Morrell

bioRxiv· January 2023

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Reduced circulating BMP9 and pBMP10 in hospitalized COVID-19 patients.
Benjamin J Dunmore, Paul D Upton, Kate Auckland, Romit J Samanta, , Nicholas W Morrell

Pulm Circ· January 2023

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The phenotype in pulmonary arterial hypertension: lessons for pathobiology and clinical management.
Jurjan Aman, Nicholas W Morrell, Christopher J Rhodes, Martin R Wilkins, Harm Jan Bogaard

Eur Respir J· December 2022

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