Publications by authors named "Nicholas P Ho"

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The calcium channel agonist (±)-BAY-K-8644 attenuates the ability of gabapentinoids to increase the potency of fentanyl and heroin and decrease the potency of cocaine and d-methamphetamine to elicit discriminative stimulus effects in rats.
Takato Hiranita, Amanda K Grisham, Abram E Mijares, Nicholas P Ho, Charles P France

J Pharmacol Exp Ther· May 2025

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The Mitragyna speciosa (kratom) alkaloid mitragynine: Analysis of adrenergic α receptor activity in vitro and in vivo.
Samuel Obeng, Morgan L Crowley, Marco Mottinelli, Francisco León, Julio D Zuarth Gonzalez, Nicholas P Ho, Lance R McMahon

Eur J Pharmacol· October 2024

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Comparison of the -Opioid Receptor Antagonists Methocinnamox and Naloxone to Reverse and Prevent the Ventilatory Depressant Effects of Fentanyl, Carfentanil, 3-Methylfentanyl, and Heroin in Male Rats.
Takato Hiranita, Nicholas P Ho, Charles P France

J Pharmacol Exp Ther· September 2024

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Ventilatory Effects of Fentanyl, Heroin, and -Methamphetamine, Alone and in Mixtures in Male Rats Breathing Normal Air .
Takato Hiranita, Nicholas P Ho, Charles P France

J Pharmacol Exp Ther· January 2024

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Pharmacokinetic and Pharmacodynamic Consequences of Cytochrome P450 3A Inhibition on Mitragynine Metabolism in Rats.
Shyam H Kamble, Samuel Obeng, Francisco León, Luis F Restrepo, Tamara I King, Erin C Berthold, Nicholas P Ho, Lance R McMahon

J Pharmacol Exp Ther· June 2023

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Interactive Effects of -Opioid and Adrenergic- Receptor Agonists in Rats: Pharmacological Investigation of the Primary Kratom Alkaloid Mitragynine and Its Metabolite 7-Hydroxymitragynine.
Samuel Obeng, Francisco Leon, Avi Patel, Julio D Zuarth Gonzalez, Lucas Chaves Da Silva, Nicholas P Ho, Lance R McMahon

J Pharmacol Exp Ther· December 2022

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The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study.
Erin C Berthold, Shyam H Kamble, Kanumuri S Raju, Michelle A Kuntz, Alexandria S Senetra, Nicholas P Ho, Lance R McMahon

Drug Metab Dispos· February 2022

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The use of hypercapnic conditions to assess opioid-induced respiratory depression in rats.
Morgan L Crowley, Luis F Restrepo, Lea R Gamez-Jimenez, Avi Patel, Tobias Braun, Nicholas P Ho, Lance R McMahon

J Pharmacol Toxicol Methods· November 2021

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Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for -Opioid Receptor and Opioid-Like Behavioral Effects in Rats.
Samuel Obeng, Jenny L Wilkerson, Francisco León, Morgan E Reeves, Luis F Restrepo, Nicholas P Ho, Lance R McMahon

J Pharmacol Exp Ther· March 2021

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