Publications by authors named "Nicholas Paradis"

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New acridone derivatives to target telomerase and oncogenes - an anticancer approach.
Tiago J S Marques, Diana Salvador, Helena Oliveira, Vanda V Serra, Nicholas Paradis

RSC Med Chem· June 2025

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Substitution-Mutation Rate Ratio (c/µ) As Molecular Adaptation Test Beyond Ka/Ks: A SARS-COV-2 Case Study.
Chun Wu, Nicholas J Paradis, Khushi Jain

J Mol Evol· June 2025

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Computational analysis of natural compounds as potential phosphodiesterase type 5A inhibitors.
Abdullahi Ibrahim Uba, Nicholas Joseph Paradis, Chun Wu, Gokhan Zengin

Comput Biol Chem· December 2024

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Enhanced detection and molecular modeling of adaptive mutations in SARS-CoV-2 coding and non-coding regions using the c/µ test.
Nicholas J Paradis, Chun Wu

Virus Evol· November 2024

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Oncogenic and telomeric G-quadruplexes: Targets for porphyrin-triphenylphosphonium conjugates.
Nuno M M Moura, Sofia Guedes, Diana Salvador, Helena Oliveira, Mariana Q Alves, Nicholas Paradis

Int J Biol Macromol· October 2024

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Binding Mechanism of the Active Form of Molnupiravir to RdRp of SARS-CoV-2 and Designing Potential Analogues: Insights from Molecular Dynamics Simulations.
Justin Carbone, Nicholas J Paradis, Dylan Brunt, Chun Wu

ACS Omega· October 2024

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Novel Inhibitors to MmpL3 Transporter of by Structure-Based High-Throughput Virtual Screening and Molecular Dynamics Simulations.
Hetanshi Choksi, Justin Carbone, Nicholas J Paradis, Lucas Bennett, Candice Bui-Linh

ACS Omega· March 2024

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Phenolic compounds as potential adenosine deaminase inhibitors: molecular docking and dynamics simulation coupled with MM-GBSA calculations.
Abdullahi Ibrahim Uba, Nicholas Joseph Paradis, Chun Wu, Gokhan Zengin

Amino Acids· December 2023

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Appraisals on the chemical characterization and biological potentials of Ranunculus constantinopolitanus extracts using chromatographic, computational, and molecular network approaches.
Irina Lazarova, Gokhan Zengin, Diletta Piatti, Abdullahi Ibrahim Uba, Gianni Sagratini, Nicholas Joseph Paradis

Food Chem Toxicol· November 2023

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Probing the Activation Mechanisms of Agonist DPI-287 to Delta-Opioid Receptor and Novel Agonists Using Ensemble-Based Virtual Screening with Molecular Dynamics Simulations.
Emily Dean, AnneMarie Dominique, Americus Palillero, Annie Tran, Nicholas Paradis

ACS Omega· September 2023

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Inhibition Mechanism of Anti-TB Drug SQ109: Allosteric Inhibition of TMM Translocation of Mycobacterium Tuberculosis MmpL3 Transporter.
Justin Carbone, Nicholas J Paradis, Lucas Bennet, Mark C Alesiani, Katherine R Hausman

J Chem Inf Model· August 2023

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L-shaped distribution of the relative substitution rate (c/μ) observed for SARS-COV-2's genome, inconsistent with the selectionist theory, the neutral theory and the nearly neutral theory but a near-neutral balanced selection theory: Implication on "neutralist-selectionist" debate.
Chun Wu, Nicholas J Paradis, Phillip M Lakernick, Mariya Hryb

Comput Biol Med· February 2023

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Unraveling the binding mechanism of the active form of Remdesivir to RdRp of SARS-CoV-2 and designing new potential analogues: Insights from molecular dynamics simulations.
Muhammad Arba, Nicholas Paradis, Setyanto T Wahyudi, Dylan J Brunt, Katherine R Hausman

Chem Phys Lett· July 2022

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Thermodynamic destabilization of azurin by four different tetramethylguanidinium amino acid ionic liquids.
Isabella DeStefano, Gabriella DeStefano, Nicholas J Paradis, Roshani Patel, Austin K Clark

Int J Biol Macromol· June 2021

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Mechanistic insight on the remdesivir binding to RNA-Dependent RNA polymerase (RdRp) of SARS-cov-2.
Muhammad Arba, Setyanto Tri Wahyudi, Dylan J Brunt, Nicholas Paradis, Chun Wu

Comput Biol Med· February 2021

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Effects of Ionic Liquids on Metalloproteins.
Aashka Y Patel, Keertana S Jonnalagadda, Nicholas Paradis, Timothy D Vaden, Chun Wu

Molecules· January 2021

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To probe the binding pathway of a selective compound (D089-0563) to c-MYC Pu24 G-quadruplex using free ligand binding simulations and Markov state model analysis.
Brian Chen, Griffin Fountain, Holli-Joi Sullivan, Nicholas Paradis, Chun Wu

Phys Chem Chem Phys· October 2020

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