Publications by authors named "Nicholas Polizzi"

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C
Conformational regulation of two essential activators of bacterial cell elongation.
Morgan S A Gilman, Irina Shlosman, Daniel D Samé Guerra, Masy Domecillo, Elayne M Fivenson, Nicholas F Polizzi

Proc Natl Acad Sci U S A· November 2025

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Rapid clearance of achiral small-molecule drugs using de novo-designed proteins and their cyclic and mirror-image variants.
Guilin Chen, Kai Zhao, Mengjiao Li, Yuefei Zhang, Tian Li, Nicholas F Polizzi

Nat Biomed Eng· October 2025

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design of semisynthetic protein nanopores.
Lee Schnaider, A Katherine Hatstat, Alistair J Scott, Sophia K Tan, Richard G Hambley, Nicholas F Polizzi

bioRxiv· September 2025

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Emergence of specific binding and catalysis from a designed generalist binding protein.
Yuda Chen, Sagar Bhattacharya, Lena Bergmann, Galen J Correy, Sophia K Tan, Nicholas F Polizzi

bioRxiv· July 2025

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How do you anticipate computational protein design will change biotechnology and therapeutic development?
Derek N Woolfson, Lucy J Colwell, Zibo Chen, Anastassia A Vorobieva, Nicholas F Polizzi

Cell Syst· November 2024

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MreC-MreD structure reveals a multifaceted interface that controls MreC conformation.
Morgan S A Gilman, Irina Shlosman, Daniel D Samé Guerra, Masy Domecillo, Elayne M Fivenson, Nicholas F Polizzi

bioRxiv· October 2024

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design of peptides that bind specific conformers of α-synuclein.
Hailey M Wallace, Hyunjun Yang, Sophia Tan, Henry S Pan, Rose Yang, Nicholas F Polizzi

Chem Sci· June 2024

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De novo design of drug-binding proteins with predictable binding energy and specificity.
Lei Lu, Xuxu Gou, Sophia K Tan, Samuel I Mann, Hyunjun Yang, Nicholas F Polizzi

Science· April 2024

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An enhanced broad-spectrum peptide inhibits Omicron variants in vivo.
Wenwen Bi, Kaiming Tang, Guilin Chen, Yubin Xie, Nicholas F Polizzi

Cell Rep Med· February 2024

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Deep Confident Steps to New Pockets: Strategies for Docking Generalization.
Gabriele Corso, Arthur Deng, Benjamin Fry, Nicholas Polizzi, Regina Barzilay

ArXiv· February 2024

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design of drug-binding proteins with predictable binding energy and specificity.
Lei Lu, Xuxu Gou, Sophia K Tan, Samuel I Mann, Hyunjun Yang, Nicholas F Polizzi

bioRxiv· December 2023

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Design of Peptides that Bind Specific Conformers of α-Synuclein.
Hailey M Wallace, Hyunjun Yang, Sophia Tan, Henry S Pan, Rose Yang, Nicholas F Polizzi

bioRxiv· November 2023

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A
Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ.
Bruk Mensa, Nicholas F Polizzi, Kathleen S Molnar, Andrew M Natale, Thomas Lemmin

Elife· December 2021

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Allosteric cooperation in a de novo-designed two-domain protein.
Fabio Pirro, Nathan Schmidt, James Lincoff, Zachary X Widel, Nicholas F Polizzi

Proc Natl Acad Sci U S A· December 2020

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A
A defined structural unit enables de novo design of small-molecule-binding proteins.
Nicholas F Polizzi, William F DeGrado

Science· September 2020

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E
Excitation energy-dependent photocurrent switching in a single-molecule photodiode.
Bing Shan, Animesh Nayak, Olivia F Williams, Dillon C Yost, Nicholas F Polizzi

Proc Natl Acad Sci U S A· August 2019

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Engineering opposite electronic polarization of singlet and triplet states increases the yield of high-energy photoproducts.
Nicholas F Polizzi, Ting Jiang, David N Beratan, Michael J Therien

Proc Natl Acad Sci U S A· July 2019

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X-ray Crystal Structure of the Influenza A M2 Proton Channel S31N Mutant in Two Conformational States: An Open and Shut Case.
Jessica L Thomaston, Yibing Wu, Nicholas Polizzi, Lijun Liu, Jun Wang

J Am Chem Soc· July 2019

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Modulating Integrin αIIbβ3 Activity through Mutagenesis of Allosterically Regulated Intersubunit Contacts.
Sophia K Tan, Karen P Fong, Nicholas F Polizzi, Alex Sternisha, Joanna S G Slusky

Biochemistry· July 2019

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Genetically Introducing Biochemically Reactive Amino Acids Dehydroalanine and Dehydrobutyrine in Proteins.
Bing Yang, Nanxi Wang, Paul D Schnier, Feng Zheng, He Zhu, Nicholas F Polizzi

J Am Chem Soc· May 2019

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I
Inhibitor binding mode and allosteric regulation of Na-glucose symporters.
Paola Bisignano, Chiara Ghezzi, Hyunil Jo, Nicholas F Polizzi, Thorsten Althoff

Nat Commun· December 2018

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Review of Practice-Based Research: A Guide for Clinicians.
Nicholas C Polizzi

Fam Syst Health· December 2018

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Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters.
Jessica L Thomaston, Nicholas F Polizzi, Athina Konstantinidi, Jun Wang, Antonios Kolocouris

J Am Chem Soc· November 2018

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De novo design of a hyperstable non-natural protein-ligand complex with sub-Å accuracy.
Nicholas F Polizzi, Yibing Wu, Thomas Lemmin, Alison M Maxwell, Shao-Qing Zhang

Nat Chem· December 2017

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