Publications by authors named "Nicholas R Boyle"

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Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia.
Nicholas R Boyle, Stephanie N Fox, Aniketh S Tadepalli, Nicholas T Seyfried, Thomas Kukar

Neurobiol Dis· September 2025

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TFEB overexpression alleviates autophagy-lysosomal deficits caused by progranulin insufficiency.
Wren O Nader, Kaylan S Brown, Nicholas R Boyle, Azariah K Kaplelach, Shaimaa M Abdelaziz

Sci Rep· July 2025

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Development of small-molecule Tau-SH3 interaction inhibitors that prevent amyloid-β toxicity and network hyperexcitability.
Jonathan R Roth, Travis Rush, Samantha J Thompson, Adam R Aldaher, Trae B Dunn, Nicholas R Boyle

Neurotherapeutics· January 2024

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Patients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations.
Skylar E Davis, Anna K Cook, Justin A Hall, Yuliya Voskobiynyk, Nancy V Carullo, Nicholas R Boyle

Acta Neuropathol Commun· April 2023

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Preclinical Interventions in Mouse Models of Frontotemporal Dementia Due to Progranulin Mutations.
Shreya N Kashyap, Nicholas R Boyle, Erik D Roberson

Neurotherapeutics· January 2023

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Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations.
Andrew E Arrant, Jonathan R Roth, Nicholas R Boyle, Shreya N Kashyap, Madelyn Q Hoffmann

Acta Neuropathol Commun· December 2019

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Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice.
Andrew E Arrant, Anthony J Filiano, Aashka R Patel, Madelyn Q Hoffmann, Nicholas R Boyle

Neurobiol Dis· April 2019

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