Publications by authors named "Nicholas R Lees"

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Chemoenzymatic total synthesis of the antibiotic (-)-13-deoxytetrodecamycin using the Diels-Alderase TedJ.
S Joe Russell, Catherine R Back, Christopher Perry, Kaiman A Cheung, Laurence Maschio, Nicholas R Lees

Chem Sci· September 2025

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Delineation of the complete reaction cycle of a natural Diels-Alderase.
Laurence Maschio, Catherine R Back, Jawaher Alnawah, James I Bowen, Samuel T Johns, Nicholas R Lees

Chem Sci· July 2024

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The Role of Cytochrome P450 AbyV in the Final Stages of Abyssomicin C Biosynthesis.
Andrew J Devine, Alice E Parnell, Catherine R Back, Nicholas R Lees, Samuel T Johns

Angew Chem Int Ed Engl· January 2023

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The Role of Cytochrome P450 AbyV in the Final Stages of Abyssomicin C Biosynthesis.
Andrew J Devine, Alice E Parnell, Catherine R Back, Nicholas R Lees, Samuel T Johns

Angew Chem Weinheim Bergstr Ger· January 2023

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Enantioselective Organocatalytic Synthesis of Bicyclic Resorcinols an Intramolecular Friedel-Crafts-Type 1,4-Addition: Access to Cannabidiol Analogues.
Laura A Bryant, Kenneth Shankland, Hannah E Straker, Callum D Johnston, Nicholas R Lees

Adv Synth Catal· August 2021

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General Method for the Synthesis of α- or β-Deoxyaminoglycosides Bearing Basic Nitrogen.
Kevin M Hoang, Nicholas R Lees, Seth B Herzon

J Am Chem Soc· February 2021

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Addendum: Synthesis and reactivity of precolibactin 886.
Alan R Healy, Kevin M Wernke, Chung Sub Kim, Nicholas R Lees, Jason M Crawford

Nat Chem· December 2019

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Cloning, expression, and purification of intact polyketide synthase modules.
Laurence Maschio, Alice E Parnell, Nicholas R Lees, Christine L Willis, Christiane Schaffitzel

Methods Enzymol· November 2019

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Synthesis and reactivity of precolibactin 886.
Alan R Healy, Kevin M Wernke, Chung Sub Kim, Nicholas R Lees, Jason M Crawford

Nat Chem· October 2019

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Programmable Synthesis of 2-Deoxyglycosides.
Kevin M Hoang, Nicholas R Lees, Seth B Herzon

J Am Chem Soc· May 2019

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An Esterase-like Lyase Catalyzes Acetate Elimination in Spirotetronate/Spirotetramate Biosynthesis.
Nicholas R Lees, Li-Chen Han, Matthew J Byrne, Jonathan A Davies, Alice E Parnell

Angew Chem Int Ed Engl· February 2019

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The Catalytic Mechanism of a Natural Diels-Alderase Revealed in Molecular Detail.
Matthew J Byrne, Nicholas R Lees, Li-Chen Han, Marc W van der Kamp, Adrian J Mulholland

J Am Chem Soc· May 2016

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Tilting and Tumbling in Transmembrane Anion Carriers: Activity Tuning through n-Alkyl Substitution.
Sophie J Edwards, Igor Marques, Christopher M Dias, Robert A Tromans, Nicholas R Lees

Chemistry· February 2016

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