Publications by authors named "Nicholas R Perl"

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PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven acquired resistance in preclinical cancer models.
Chun Wai Wong, Christos Evangelou, Kieran N Sefton, Rotem Leshem, Wei Zhang, Nicholas R Perl

Nat Commun· September 2023

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Targeted Degradation of PARP14 Using a Heterobifunctional Small Molecule.
Tim J Wigle, Yue Ren, Jennifer R Molina, Danielle J Blackwell, Laurie B Schenkel, Nicholas R Perl

Chembiochem· June 2021

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Discovery of CYR715: A novel carboxylic acid-containing soluble guanylate cyclase stimulator.
Glen R Rennie, Timothy C Barden, Sylvie G Bernier, Andrew Carvalho, Renee Deming, Nicholas R Perl

Bioorg Med Chem Lett· May 2021

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In Vitro and Cellular Probes to Study PARP Enzyme Target Engagement.
Tim J Wigle, Danielle J Blackwell, Laurie B Schenkel, Yue Ren, W David Church, Nicholas R Perl

Cell Chem Biol· July 2020

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Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans.
Takashi Nakai, Nicholas R Perl, Timothy C Barden, Andrew Carvalho, Angelika Fretzen

ACS Med Chem Lett· May 2016

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The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes.
Pei Ge, Iris D Navarro, Marco M Kessler, Sylvie G Bernier, Nicholas R Perl

Invest Ophthalmol Vis Sci· March 2016

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Design and synthesis of potent Quillaja saponin vaccine adjuvants.
Michelle M Adams, Payal Damani, Nicholas R Perl, Annie Won, Feng Hong

J Am Chem Soc· February 2010

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Annulation of thioimidates and vinyl carbodiimides to prepare 2-aminopyrimidines, competent nucleophiles for intramolecular alkyne hydroamination. Synthesis of (-)-crambidine.
Nicholas R Perl, Nathan D Ide, Sudeep Prajapati, Hahdi H Perfect, Sergio G Durón

J Am Chem Soc· February 2010

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Allylsilane-vinylarene cross-metathesis enables a powerful approach to enantioselective imine allylation.
John D Huber, Nicholas R Perl, James L Leighton

Angew Chem Int Ed Engl· June 2008

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Enantioselective imidazole-directed allylation of aldimines and ketimines.
Nicholas R Perl, James L Leighton

Org Lett· August 2007

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Competitive cationic pathways and the asymmetric synthesis of aryl-substituted cyclopropanes.
Bruce J Melancon, Nicholas R Perl, Richard E Taylor

Org Lett· April 2007

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Tandem aldol-allylation and aldol-aldol reactions with ketone-derived enolsilanes: highly diastereoselective single-step synthesis of complex tertiary carbinols.
Xiaolun Wang, Qinglin Meng, Nicholas R Perl, Yue Xu, James L Leighton

J Am Chem Soc· September 2005

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