Publications by authors named "Nico Scheer"

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Analysis of the Bile Acid Composition in a Fibroblast Growth Factor 19-Expressing Liver-Humanized Mouse Model and Its Use for CYP3A4-Mediated Drug-Drug Interaction Studies.
Mario Mezler, Robert S Jones, Dewakar Sangaraju, Devorah C Goldman, Matthew Hoffmann, Nico Scheer

Drug Metab Dispos· October 2023

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Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.
Yasuhiro Kazuki, Kaoru Kobayashi, Masumi Hirabayashi, Satoshi Abe, Naoyo Kajitani, Nico Scheer

Proc Natl Acad Sci U S A· February 2019

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Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model.
Shannon Dallas, Laurent Salphati, David Gomez-Zepeda, Thomas Wanek, Liangfu Chen, Nico Scheer

Mol Pharmacol· May 2016

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Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4-Humanized Mouse Studies With PBPK Modeling.
Jin Zhang, Tycho Heimbach, Nico Scheer, Avantika Barve, Wenkui Li

J Pharm Sci· April 2016

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A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity.
Nico Scheer, Ian D Wilson

Drug Discov Today· February 2016

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Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model.
Nico Scheer, Yury Kapelyukh, Anja Rode, Stefan Oswald, Diana Busch

Drug Metab Dispos· November 2015

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Opioid Analgesia in P450 Gene Cluster Knockout Mice: A Search for Analgesia-Relevant Isoforms.
Lindsay B Hough, Julia W Nalwalk, Xinxin Ding, Nico Scheer

Drug Metab Dispos· September 2015

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Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo.
Colin J Henderson, Lesley A McLaughlin, Nico Scheer, Lesley A Stanley, C Roland Wolf

Mol Pharmacol· April 2015

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Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins.
Laurent Salphati, Xiaoyan Chu, Liangfu Chen, Bhagwat Prasad, Shannon Dallas, Nico Scheer

Drug Metab Dispos· August 2014

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Deletion of 30 murine cytochrome p450 genes results in viable mice with compromised drug metabolism.
Nico Scheer, Lesley A McLaughlin, Anja Rode, A Kenneth Macleod, Colin J Henderson

Drug Metab Dispos· June 2014

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Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors.
Raphaëlle Luisier, Harri Lempiäinen, Nina Scherbichler, Albert Braeuning, Miriam Geissler, Nico Scheer

Toxicol Sci· June 2014

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Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications.
Nico Scheer, C Roland Wolf

Xenobiotica· January 2014

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Generation and utility of genetically humanized mouse models.
Nico Scheer, Mike Snaith, C Roland Wolf, Jost Seibler

Drug Discov Today· December 2013

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Identification of Dlk1-Dio3 imprinted gene cluster noncoding RNAs as novel candidate biomarkers for liver tumor promotion.
Harri Lempiäinen, Philippe Couttet, Federico Bolognani, Arne Müller, Valérie Dubost, Nico Scheer

Toxicol Sci· February 2013

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Xenobiotic receptor humanized mice and their utility.
Nico Scheer, C Roland Wolf

Drug Metab Rev· February 2013

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Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines.
Nico Scheer, Yury Kapelyukh, Lynsey Chatham, Anja Rode, Sandra Buechel

Mol Pharmacol· December 2012

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Generation and characterization of a novel multidrug resistance protein 2 humanized mouse line.
Nico Scheer, Praveen Balimane, Michael D Hayward, Sandra Buechel, Gunther Kauselmann

Drug Metab Dispos· November 2012

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Modeling human cytochrome P450 2D6 metabolism and drug-drug interaction by a novel panel of knockout and humanized mouse lines.
Nico Scheer, Yury Kapelyukh, Jillian McEwan, Vincent Beuger, Lesley A Stanley

Mol Pharmacol· January 2012

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Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line.
Maki Hasegawa, Yury Kapelyukh, Harunobu Tahara, Jost Seibler, Anja Rode, Nico Scheer

Mol Pharmacol· September 2011

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Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.
Jillian Ross, Simon M Plummer, Anja Rode, Nico Scheer, Conrad C Bower

Toxicol Sci· August 2010

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In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice.
Nico Scheer, Jillian Ross, Yury Kapelyukh, Anja Rode, C Roland Wolf

Drug Metab Dispos· July 2010

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Drug transporters: gatekeepers controlling access of xenobiotics to the cellular interior.
Lesley A Stanley, Brian C Horsburgh, Jillian Ross, Nico Scheer, C Roland Wolf

Drug Metab Rev· August 2009

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Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man.
Colin J Henderson, Nico Scheer, C Roland Wolf

Expert Rev Clin Pharmacol· March 2009

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A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.
Nico Scheer, Jillian Ross, Anja Rode, Branko Zevnik, Sandra Niehaves

J Clin Invest· September 2008

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PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.
Lesley A Stanley, Brian C Horsburgh, Jillian Ross, Nico Scheer, C Roland Wolf

Drug Metab Rev· September 2006

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