Publications by authors named "Nicolas D Werbeck"

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A distal regulatory region of a class I human histone deacetylase.
Nicolas D Werbeck, Vaibhav Kumar Shukla, Micha B A Kunze, Havva Yalinca, Ruth B Pritchard

Nat Commun· July 2020

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Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target.
Krzysztof Brzezinka, Ekaterina Nevedomskaya, Ralf Lesche, Andrea Haegebarth, Antonius Ter Laak, Nicolas D Werbeck

Cancers (Basel)· January 2020

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Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.
Roman C Hillig, Brice Sautier, Jens Schroeder, Dieter Moosmayer, André Hilpmann, Nicolas D Werbeck

Proc Natl Acad Sci U S A· February 2019

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Characterizing Active Site Conformational Heterogeneity along the Trajectory of an Enzymatic Phosphoryl Transfer Reaction.
Cathleen Zeymer, Nicolas D Werbeck, Sabine Zimmermann, Jochen Reinstein, D Flemming Hansen

Angew Chem Int Ed Engl· September 2016

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Heteronuclear transverse and longitudinal relaxation in AX4 spin systems: application to (15)N relaxations in (15)NH4(+).
Nicolas D Werbeck, D Flemming Hansen

J Magn Reson· September 2014

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Using ¹⁵N-ammonium to characterise and map potassium binding sites in proteins by NMR spectroscopy.
Nicolas D Werbeck, John Kirkpatrick, Jochen Reinstein, D Flemming Hansen

Chembiochem· March 2014

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Elements in nucleotide sensing and hydrolysis of the AAA+ disaggregation machine ClpB: a structure-based mechanistic dissection of a molecular motor.
Cathleen Zeymer, Thomas R M Barends, Nicolas D Werbeck, Ilme Schlichting, Jochen Reinstein

Acta Crystallogr D Biol Crystallogr· February 2014

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Loop interactions and dynamics tune the enzymatic activity of the human histone deacetylase 8.
Micha B A Kunze, David W Wright, Nicolas D Werbeck, John Kirkpatrick, Peter V Coveney

J Am Chem Soc· November 2013

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The molecular mechanism of Hsp100 chaperone inhibition by the prion curing agent guanidinium chloride.
Cathleen Zeymer, Nicolas D Werbeck, Ilme Schlichting, Jochen Reinstein

J Biol Chem· March 2013

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Probing arginine side-chains and their dynamics with carbon-detected NMR spectroscopy: application to the 42 kDa human histone deacetylase 8 at high pH.
Nicolas D Werbeck, John Kirkpatrick, D Flemming Hansen

Angew Chem Int Ed Engl· March 2013

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Coupling of oligomerization and nucleotide binding in the AAA+ chaperone ClpB.
Nicolas D Werbeck, Cathleen Zeymer, Julian N Kellner, Jochen Reinstein

Biochemistry· February 2011

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Disaggregases in 4 dimensions.
Thomas R M Barends, Nicolas D Werbeck, Jochen Reinstein

Curr Opin Struct Biol· February 2010

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Nucleotide binding and allosteric modulation of the second AAA+ domain of ClpB probed by transient kinetic studies.
Nicolas D Werbeck, Julian N Kellner, Thomas R M Barends, Jochen Reinstein

Biochemistry· August 2009

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Strategic roles of axial histidines in structure formation and redox regulation of tetraheme cytochrome c3.
Yuki Takayama, Nicolas D Werbeck, Hirofumi Komori, Kumiko Morita, Kiyoshi Ozawa

Biochemistry· September 2008

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Shifting transition states in the unfolding of a large ankyrin repeat protein.
Nicolas D Werbeck, Pamela J E Rowling, Vasuki R Chellamuthu, Laura S Itzhaki

Proc Natl Acad Sci U S A· July 2008

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The ATPase cycle of the mitochondrial Hsp90 analog Trap1.
Adriane Leskovar, Harald Wegele, Nicolas D Werbeck, Johannes Buchner, Jochen Reinstein

J Biol Chem· April 2008

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Coupling and dynamics of subunits in the hexameric AAA+ chaperone ClpB.
Nicolas D Werbeck, Sandra Schlee, Jochen Reinstein

J Mol Biol· April 2008

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Probing a moving target with a plastic unfolding intermediate of an ankyrin-repeat protein.
Nicolas D Werbeck, Laura S Itzhaki

Proc Natl Acad Sci U S A· May 2007

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