Publications by authors named "Nicolas Floc'h"

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AZ14289671 is a highly selective and blood-brain barrier penetrant irreversible TKI that targets EGFRExon20 insertions.
Aisha M Swaih, Sara Talbot, Adriana Savoca, Hannah Thorpe, Vikki Flemington, Nicolas Floc'h

Cell Rep Med· September 2025

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KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer.
Ana Galan-Cobo, Natalie I Vokes, Yu Qian, David Molkentine, Kavya Ramkumar, Nicolas Floc'h

Cancer Cell· August 2025

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Highly Optimized CNS Penetrant Inhibitors of EGFR Exon20 Insertion Mutations.
William McCoull, Clare Thomson, Erin Braybrooke, Christina Chan, Nicola Colclough, Nicolas Floc'h

J Med Chem· February 2025

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Overcoming Osimertinib Resistance with AKT Inhibition in EGFRm-Driven Non-Small Cell Lung Cancer with PIK3CA/PTEN Alterations.
Ursula Grazini, Aleksandra Markovets, Lucy Ireland, Daniel O'Neill, Benjamin Phillips, Nicolas Floc'h

Clin Cancer Res· September 2024

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Optimization of Potent, Efficacious, Selective and Blood-Brain Barrier Penetrating Inhibitors Targeting EGFR Exon20 Insertion Mutations.
Clare Thomson, Erin Braybrooke, Nicola Colclough, Nichola L Davies, Nicolas Floc'h

J Med Chem· September 2024

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A forward genetic screen identifies Sirtuin1 as a driver of neuroendocrine prostate cancer.
Francisca Nunes de Almeida, Alessandro Vasciaveo, Ainsley Mike Antao, Min Zou, Matteo Di Bernardo, Nicolas Floc'h

bioRxiv· August 2024

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Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations.
Clare Thomson, Peter Barton, Erin Braybrooke, Nicola Colclough, Zhiqiang Dong, Nicolas Floc'h

J Med Chem· June 2024

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BID expression determines the apoptotic fate of cancer cells after abrogation of the spindle assembly checkpoint by AURKB or TTK inhibitors.
Jordi Bertran-Alamillo, Ana Giménez-Capitán, Ruth Román, Sara Talbot, Rebecca Whiteley, Nicolas Floc'h

Mol Cancer· July 2023

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The landscape of therapeutic vulnerabilities in EGFR inhibitor osimertinib drug tolerant persister cells.
Steven W Criscione, Matthew J Martin, Derek B Oien, Aparna Gorthi, Ricardo J Miragaia, Nicolas Floc'h

NPJ Precis Oncol· December 2022

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Pharmaceutical Reactivation of Attenuated Apoptotic Pathways Leads to Elimination of Osimertinib Drug-Tolerant Cells.
Matthew J Martin, Nicolas Floc'h, Matthias Pfeifer, Steven Criscione, Oona Delpuech

Cancer Res Commun· October 2022

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Anti-PD-L1 and anti-CD73 combination therapy promotes T cell response to EGFR-mutated NSCLC.
Eric Tu, Kelly McGlinchey, Jixin Wang, Philip Martin, Steven Lk Ching, Nicolas Floc'h

JCI Insight· February 2022

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Simplification, not "tropicalization", of temperate marine ecosystems under ocean warming and acidification.
Sylvain Agostini, Ben P Harvey, Marco Milazzo, Shigeki Wada, Koetsu Kon, Nicolas Floc'h

Glob Chang Biol· October 2021

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Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance.
M Raymond V Finlay, Peter Barton, Sue Bickerton, Michal Bista, Nicola Colclough, Nicolas Floc'h

J Med Chem· September 2021

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Challenges and Opportunities in Cancer Drug Resistance.
Richard A Ward, Stephen Fawell, Nicolas Floc'h, Vikki Flemington, Darren McKerrecher

Chem Rev· March 2021

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Osimertinib, an Irreversible Next-Generation EGFR Tyrosine Kinase Inhibitor, Exerts Antitumor Activity in Various Preclinical NSCLC Models Harboring the Uncommon EGFR Mutations G719X or L861Q or S768I.
Nicolas Floc'h, Sangbin Lim, Sue Bickerton, Afshan Ahmed, Jonathan Orme

Mol Cancer Ther· November 2020

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Modeling Dose and Schedule Effects of AZD2811 Nanoparticles Targeting Aurora B Kinase for Treatment of Diffuse Large B-cell Lymphoma.
Nicolas Floc'h, Susan Ashton, Douglas Ferguson, Paula Taylor, Larissa S Carnevalli

Mol Cancer Ther· May 2019

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Optimizing the design of population-based patient-derived tumor xenograft studies to better predict clinical response.
Nicolas Floc'h, Maria Luisa Guerriero, Antonio Ramos-Montoya, Barry R Davies, Jonathan Cairns

Dis Model Mech· October 2018

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Reactivation of Mutant-EGFR Degradation through Clathrin Inhibition Overcomes Resistance to EGFR Tyrosine Kinase Inhibitors.
Ludovic Ménard, Nicolas Floc'h, Matthew J Martin, Darren A E Cross

Cancer Res· June 2018

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Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions.
Nicolas Floc'h, Matthew J Martin, Jonathan W Riess, Jonathan P Orme, Anna D Staniszewska

Mol Cancer Ther· May 2018

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Optimizing Therapeutic Effect of Aurora B Inhibition in Acute Myeloid Leukemia with AZD2811 Nanoparticles.
Nicolas Floc'h, Susan Ashton, Paula Taylor, Dawn Trueman, Emily Harris

Mol Cancer Ther· June 2017

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Modulation of oxidative stress by twist oncoproteins.
Nicolas Floc'h, Jakub Kolodziejski, Leila Akkari, Yannick Simonin, Stéphane Ansieau

PLoS One· May 2014

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Lymphotoxin signaling is initiated by the viral polymerase in HCV-linked tumorigenesis.
Yannick Simonin, Serena Vegna, Leila Akkari, Damien Grégoire, Etienne Antoine, Nicolas Floc'h

PLoS Pathog· March 2013

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The promise of dual targeting Akt/mTOR signaling in lethal prostate cancer.
Nicolas Floc'h, Cory Abate-Shen

Oncotarget· December 2012

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Dual targeting of the Akt/mTOR signaling pathway inhibits castration-resistant prostate cancer in a genetically engineered mouse model.
Nicolas Floc'h, Carolyn Waugh Kinkade, Takashi Kobayashi, Alvaro Aytes, Celine Lefebvre

Cancer Res· September 2012

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B-Raf activation cooperates with PTEN loss to drive c-Myc expression in advanced prostate cancer.
Jingqiang Wang, Takashi Kobayashi, Nicolas Floc'h, Carolyn Waugh Kinkade, Alvaro Aytes

Cancer Res· September 2012

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