Publications by authors named "Nieng Yan"

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Phrixotoxin-3 binds to three distinct antagonistic sites on human Na1.6.
Xiao Fan, Jiaofeng Chen, Xiaoshuang Huang, Zhanfeng Hou, Yuzhen Xie, Nieng Yan

Cell Res· August 2025

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Critical role of extracellular loops in differential modulations of TTX-sensitive and TTX-resistant Na channels.
Tong Wu, Xinyu Yang, Xueqin Jin, Nieng Yan, Zhangqiang Li

Proc Natl Acad Sci U S A· August 2025

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Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine).
John N Wood, Nieng Yan, Jian Huang, Jing Zhao, Armen Akopian

J Gen Physiol· July 2025

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Deciphering Ca permeation and valence selectivity in Ca1: Molecular dynamics simulations reveal the three-ion knock-on mechanism.
Lingfeng Xue, Nieng Yan, Chen Song

Proc Natl Acad Sci U S A· June 2025

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CryoPROS: Correcting misalignment caused by preferred orientation using AI-generated auxiliary particles.
Hui Zhang, Dihan Zheng, Qiurong Wu, Nieng Yan, Han Peng, Zhaofeng Yan

Nat Commun· May 2025

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Corrigendum to "Drug discovery targeting Na1.8: Structural insights and therapeutic potential" [Curr Opin Chem Biol 83 (2024) 102538].
Huan Wang, Jian Huang, Jie Zang, Xueqin Jin, Nieng Yan

Curr Opin Chem Biol· February 2025

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CryoSeek II: Cryo-EM analysis of glycofibrils from freshwater reveals well-structured glycans coating linear tetrapeptide repeats.
Tongtong Wang, Wenze Huang, Kui Xu, Yitong Sun, Qiangfeng Cliff Zhang, Chuangye Yan, Nieng Yan

Proc Natl Acad Sci U S A· January 2025

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A structural atlas of druggable sites on Na channels.
Zhangqiang Li, Qiurong Wu, Nieng Yan

Channels (Austin)· December 2024

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Structural biology of voltage-gated calcium channels.
Xia Yao, Shuai Gao, Nieng Yan

Channels (Austin)· December 2024

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Drug discovery targeting Na1.8: Structural insights and therapeutic potential.
Huan Wang, Jian Huang, Jie Zang, Xueqin Jin, Nieng Yan

Curr Opin Chem Biol· December 2024

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Cryo-EM structure of histidyl-tRNA synthetase-like domain reveals activating crossed helices at the core of GCN2.
Kristina Solorio-Kirpichyan, Xiao Fan, Dmitrij Golovenko, Andrei A Korostelev, Nieng Yan

PNAS Nexus· December 2024

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Structural biology and molecular pharmacology of voltage-gated ion channels.
Jian Huang, Xiaojing Pan, Nieng Yan

Nat Rev Mol Cell Biol· November 2024

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Author Correction: Structural biology and molecular pharmacology of voltage-gated ion channels.
Jian Huang, Xiaojing Pan, Nieng Yan

Nat Rev Mol Cell Biol· November 2024

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CryoSeek: A strategy for bioentity discovery using cryoelectron microscopy.
Tongtong Wang, Zhangqiang Li, Kui Xu, Wenze Huang, Gaoxingyu Huang, Nieng Yan

Proc Natl Acad Sci U S A· October 2024

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A versatile residue numbering scheme for Na and Ca channels.
Xueqin Jin, Jian Huang, Huan Wang, Kan Wang, Nieng Yan

Cell Chem Biol· August 2024

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Structural basis for different ω-agatoxin IVA sensitivities of the P-type and Q-type Ca2.1 channels.
Zhangqiang Li, Ye Cong, Tong Wu, Tongtong Wang, Xinyao Lou, Xinyu Yang, Nieng Yan

Cell Res· June 2024

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Structural basis for human Ca3.2 inhibition by selective antagonists.
Jian Huang, Xiao Fan, Xueqin Jin, Chen Lyu, Qinmeng Guo, Nieng Yan

Cell Res· June 2024

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Author Correction: Cryo-EM structures of apo and antagonist-bound human Ca3.1.
Yanyu Zhao, Gaoxingyu Huang, Qiurong Wu, Kun Wu, Ruiqi Li, Nieng Yan

Nature· June 2024

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Cryo-EM Structure of HRSL Domain Reveals Activating Crossed Helices at the Core of GCN2.
Kristina Solorio-Kirpichyan, Xiao Fan, Dmitrij Golovenko, Andrei A Korostelev, Nieng Yan

bioRxiv· April 2024

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Structure-guided discovery of protein and glycan components in native mastigonemes.
Junhao Huang, Hui Tao, Jikun Chen, Yang Shen, Jianlin Lei, Chuangye Yan, Nieng Yan

Cell· March 2024

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Dissection of the structure-function relationship of Na channels.
Zhangqiang Li, Qiurong Wu, Gaoxingyu Huang, Xueqin Jin, Jiaao Li, Nieng Yan

Proc Natl Acad Sci U S A· February 2024

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Structural basis for human Ca1.2 inhibition by multiple drugs and the neurotoxin calciseptine.
Shuai Gao, Xia Yao, Jiaofeng Chen, Gaoxingyu Huang, Xiao Fan, Yan Wang, Nieng Yan

Cell· November 2023

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Dual-pocket inhibition of Na channels by the antiepileptic drug lamotrigine.
Jian Huang, Xiao Fan, Xueqin Jin, Liming Teng, Nieng Yan

Proc Natl Acad Sci U S A· October 2023

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Structural mapping of Na1.7 antagonists.
Qiurong Wu, Jian Huang, Xiao Fan, Kan Wang, Xueqin Jin, Nieng Yan

Nat Commun· June 2023

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Cannabidiol inhibits Na channels through two distinct binding sites.
Jian Huang, Xiao Fan, Xueqin Jin, Sooyeon Jo, Hanxiong Bear Zhang, Nieng Yan

Nat Commun· June 2023

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