Publications by authors named "Nigel A Calcutt"

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Topical application of the antimuscarinic pirenzepine increased lower limb nerve fibre density in a phase 2a study in type 2 patients with diabetes with peripheral neuropathy.
Ajith Sivadasan, Paul Fernyhough, Nigel A Calcutt, Katie E Frizzi, Kimberly Gardner

EBioMedicine· December 2025

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Optimization of a synoviocyte-targeted biologic for inflammatory arthritis in combination or bispecific administration with TNF inhibitors.
Sterling H Ramsey, Zixuan Zhao, Megan C Lee, Thales Hein da Rosa, Ava C Schneider, Nigel A Calcutt

JCI Insight· November 2025

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Muscarinic Receptor Antagonism and TRPM3 Activation as Stimulators of Mitochondrial Function and Axonal Repair in Diabetic Sensorimotor Polyneuropathy.
Sanjana Chauhan, Nigel A Calcutt, Paul Fernyhough

Int J Mol Sci· July 2025

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Rate-Dependent Depression of the Hoffmann Reflex: Practical Applications in Painful Diabetic Neuropathy.
Lu Han, Nigel A Calcutt, Xiajun Zhou

Diabetes Metab J· November 2024

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A muscarinic receptor antagonist reverses multiple indices of diabetic peripheral neuropathy: preclinical and clinical studies using oxybutynin.
Carolina M Casselini, Henri K Parson, Katie E Frizzi, Alex Marquez, Darrell R Smith, Nigel A Calcutt

Acta Neuropathol· March 2024

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Insulin-regulated serine and lipid metabolism drive peripheral neuropathy.
Michal K Handzlik, Jivani M Gengatharan, Katie E Frizzi, Grace H McGregor, Cameron Martino, Nigel A Calcutt

Nature· February 2023

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Spinal disinhibition: evidence for a hyperpathia phenotype in painful diabetic neuropathy.
Anne Marshall, Alise Kalteniece, Maryam Ferdousi, Shazli Azmi, Edward B Jude, Nigel A Calcutt

Brain Commun· February 2023

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Rapamycin/metformin co-treatment normalizes insulin sensitivity and reduces complications of metabolic syndrome in type 2 diabetic mice.
Peter C Reifsnyder, Kevin Flurkey, Rosalinda Doty, Nigel A Calcutt, Robert A Koza

Aging Cell· September 2022

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Rate-Dependent Depression: A Predictor of the Therapeutic Efficacy in Treating Painful Diabetic Peripheral Neuropathy.
Xiajun Zhou, Ying Zhu, Ze Wang, Zhi Lin, Desheng Zhu, Nigel A Calcutt

Diabetes· June 2022

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Using Corneal Confocal Microscopy to Identify Therapeutic Agents for Diabetic Neuropathy.
Corinne G Jolivalt, May Madi Han, Annee Nguyen, Fiona Desmond, Carlos Henrique Alves Jesus, Nigel A Calcutt

J Clin Med· April 2022

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Rate-dependent depression is impaired in amyotrophic lateral sclerosis.
Xiajun Zhou, Ze Wang, Zhi Lin, Ying Zhu, Desheng Zhu, Nigel A Calcutt

Neurol Sci· March 2022

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CEBPβ regulation of endogenous IGF-1 in adult sensory neurons can be mobilized to overcome diabetes-induced deficits in bioenergetics and axonal outgrowth.
Mohamad-Reza Aghanoori, Prasoon Agarwal, Evan Gauvin, Raghu S Nagalingam, Raiza Bonomo, Nigel A Calcutt

Cell Mol Life Sci· March 2022

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LXR agonist improves peripheral neuropathy and modifies PNS immune cells in aged mice.
Chaitanya K Gavini, Nadia Elshareif, Gregory Aubert, Anand V Germanwala, Nigel A Calcutt

J Neuroinflammation· February 2022

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Spinal Inhibitory Dysfunction in Patients With Painful or Painless Diabetic Neuropathy.
Anne Worthington, Alise Kalteniece, Maryam Ferdousi, Luca D'Onofrio, Shaishav Dhage, Nigel A Calcutt

Diabetes Care· August 2021

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Optimal Utility of H-Reflex RDD as a Biomarker of Spinal Disinhibition in Painful and Painless Diabetic Neuropathy.
Anne Worthington, Alise Kalteniece, Maryam Ferdousi, Luca D'Onofrio, Shaishav Dhage, Nigel A Calcutt

Diagnostics (Basel)· July 2021

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Prevention of HIV-1 TAT Protein-Induced Peripheral Neuropathy and Mitochondrial Disruption by the Antimuscarinic Pirenzepine.
May Madi Han, Katie E Frizzi, Ronald J Ellis, Nigel A Calcutt, Jerel Adam Fields

Front Neurol· June 2021

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Lost in Translation? Measuring Diabetic Neuropathy in Humans and Animals (Diabetes Metab J 2021;45:27-42).
Heung Yong Jin, Seong-Su Moon, Nigel A Calcutt

Diabetes Metab J· May 2021

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Pharmacological Modulation of Rate-Dependent Depression of the Spinal H-Reflex Predicts Therapeutic Efficacy against Painful Diabetic Neuropathy.
Corinne A Lee-Kubli, XiaJun Zhou, Corinne G Jolivalt, Nigel A Calcutt

Diagnostics (Basel)· February 2021

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Metformin as a potential therapeutic for neurological disease: mobilizing AMPK to repair the nervous system.
Sarah Demaré, Asha Kothari, Nigel A Calcutt, Paul Fernyhough

Expert Rev Neurother· January 2021

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Lost in Translation? Measuring Diabetic Neuropathy in Humans and Animals.
Heung Yong Jin, Seong-Su Moon, Nigel A Calcutt

Diabetes Metab J· January 2021

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Fecal transplantation and butyrate improve neuropathic pain, modify immune cell profile, and gene expression in the PNS of obese mice.
Raiza R Bonomo, Tyler M Cook, Chaitanya K Gavini, Chelsea R White, Jacob R Jones, Nigel A Calcutt

Proc Natl Acad Sci U S A· October 2020

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Diabetic neuropathy and neuropathic pain: a (con)fusion of pathogenic mechanisms?
Nigel A Calcutt

Pain· September 2020

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Topical Delivery of Muscarinic Receptor Antagonists Prevents and Reverses Peripheral Neuropathy in Female Diabetic Mice.
Corinne G Jolivalt, Katie E Frizzi, May Madi Han, Andre J Mota, Lucie S Guernsey, Nigel A Calcutt

J Pharmacol Exp Ther· July 2020

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Muscarinic Toxin 7 Signals Via Ca/Calmodulin-Dependent Protein Kinase Kinase β to Augment Mitochondrial Function and Prevent Neurodegeneration.
Ali Saleh, Mohammad Golam Sabbir, Mohamad-Reza Aghanoori, Darrell R Smith, Subir K Roy Chowdhury, Nigel A Calcutt

Mol Neurobiol· June 2020

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Translating diabetic peripheral neuropathy.
Rayaz A Malik, Nigel A Calcutt

J Peripher Nerv Syst· June 2020

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