Publications by authors named "Nigel J Pyne"

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The Concise Guide to PHARMACOLOGY 2023/24: Enzymes.
Stephen P H Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A Mathie, John A Peters, Nigel J Pyne, Susan Pyne

Br J Pharmacol· October 2023

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Interleukin-7 receptor α mutational activation can initiate precursor B-cell acute lymphoblastic leukemia.
Afonso R M Almeida, João L Neto, Ana Cachucho, Mayara Euzébio, Xiangyu Meng, Susan Pyne, Nigel J Pyne

Nat Commun· December 2021

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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes.
Stephen Ph Alexander, Doriano Fabbro, Eamonn Kelly, Alistair Mathie, John A Peters, Nigel J Pyne, Susan Pyne

Br J Pharmacol· October 2021

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Dihydroceramide Desaturase Functions as an Inducer and Rectifier of Apoptosis: Effect of Retinol Derivatives, Antioxidants and Phenolic Compounds.
Mariam Alsanafi, Ryan D R Brown, Jeongah Oh, David R Adams, Federico Torta, Nigel J Pyne, Susan Pyne

Cell Biochem Biophys· September 2021

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A new model for regulation of sphingosine kinase 1 translocation to the plasma membrane in breast cancer cells.
Ryan D R Brown, Ben E P Veerman, Jeongah Oh, Rothwelle J Tate, Federico Torta, Susan Pyne, Nigel J Pyne

J Biol Chem· August 2021

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Structure-function analysis of lipid substrates and inhibitors of sphingosine kinases.
David R Adams, Susan Pyne, Nigel J Pyne

Cell Signal· December 2020

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Recent advances in the role of sphingosine 1-phosphate in cancer.
Nigel J Pyne, Susan Pyne

FEBS Lett· November 2020

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A Novel Selective Sphingosine Kinase 2 Inhibitor, HWG-35D, Ameliorates the Severity of Imiquimod-Induced Psoriasis Model by Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes.
Sun-Hye Shin, Hee-Yeon Kim, Hee-Soo Yoon, Woo-Jae Park, David R Adams, Nigel J Pyne, Susan Pyne

Int J Mol Sci· November 2020

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Sphingosine Kinases as Druggable Targets.
Susan Pyne, David R Adams, Nigel J Pyne

Handb Exp Pharmacol· August 2020

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The regulation of p53, p38 MAPK, JNK and XBP-1s by sphingosine kinases in human embryonic kidney cells.
Mariam Alsanafi, Samuel L Kelly, Melissa McNaughton, Alfred H Merrill, Nigel J Pyne, Susan Pyne

Biochim Biophys Acta Mol Cell Biol Lipids· April 2020

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Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-stem Breast Cancer Cells by Suppression of STAT1.
Ling-Wei Hii, Felicia Fei-Lei Chung, Chun Wai Mai, Zong Yang Yee, Hong Hao Chan, Nigel J Pyne, Susan Pyne

Cells· April 2020

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WITHDRAWN: Ceramide and Sphingosine 1-Phosphate in adipose dysfunction.
Zijian Fang, Susan Pyne, Nigel J Pyne

Prog Lipid Res· August 2019

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Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases.
Faisa Omar, Jane E Findlay, Gemma Carfray, Robert W Allcock, Zhong Jiang, Nigel J Pyne

Proc Natl Acad Sci U S A· July 2019

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Topographical Mapping of Isoform-Selectivity Determinants for J-Channel-Binding Inhibitors of Sphingosine Kinases 1 and 2.
David R Adams, Salha Tawati, Giacomo Berretta, Paula Lopez Rivas, Jessica Baiget, Nigel J Pyne, Susan Pyne

J Med Chem· April 2019

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Ceramide and sphingosine 1-phosphate in adipose dysfunction.
Zijian Fang, Susan Pyne, Nigel J Pyne

Prog Lipid Res· April 2019

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Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse.
Fiona H Greig, Katrin Nather, Margaret D Ballantyne, Zeshan H Kazi, Husam Alganga, Nigel J Pyne, Susan Pyne

Eur J Pharmacol· January 2019

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Native and Polyubiquitinated Forms of Dihydroceramide Desaturase Are Differentially Linked to Human Embryonic Kidney Cell Survival.
Mariam Alsanafi, Samuel L Kelly, Karawan Jubair, Melissa McNaughton, Rothwelle J Tate, Susan Pyne, Nigel J Pyne

Mol Cell Biol· December 2018

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Does the Sphingosine 1-Phosphate Receptor-1 Provide a Better or Worse Prognostic Outcome for Breast Cancer Patients?
Nigel J Pyne, Susan Pyne

Front Oncol· September 2018

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The sphingosine 1-phosphate receptor 2 is shed in exosomes from breast cancer cells and is N-terminally processed to a short constitutively active form that promotes extracellular signal regulated kinase activation and DNA synthesis in fibroblasts.
Ashref El Buri, David R Adams, Douglas Smith, Rothwelle J Tate, Margaret Mullin, Susan Pyne, Nigel J Pyne

Oncotarget· June 2018

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Sphingosine 1-phosphate and cancer.
Nigel J Pyne, Ashref El Buri, David R Adams, Susan Pyne

Adv Biol Regul· May 2018

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Cellular Signalling - Special issue to celebrate 75th birthday of Prof. Robert J. Lefkowitz.
Arun K Shukla, Nigel J Pyne

Cell Signal· January 2018

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Sphingosine Kinase 1: A Potential Therapeutic Target in Pulmonary Arterial Hypertension?
Nigel J Pyne, Susan Pyne

Trends Mol Med· September 2017

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Sphingosine kinase 2 and multiple myeloma.
Nigel J Pyne, Susan Pyne

Oncotarget· July 2017

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Sphingosine Kinase 2 in Autoimmune/Inflammatory Disease and the Development of Sphingosine Kinase 2 Inhibitors.
Nigel J Pyne, David R Adams, Susan Pyne

Trends Pharmacol Sci· July 2017

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Sphingosine 1-Phosphate Receptor 1 Signaling in Mammalian Cells.
Nigel J Pyne, Susan Pyne

Molecules· February 2017

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