Publications by authors named "Nigel Sharfe"

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Autosomal-dominant Roquin-1 immunodeficiency and hyperinflammation.
Amit Nahum, Nigel Sharfe, Daniele Merico, Kelli W Williams, Dionne Aleman

J Allergy Clin Immunol· November 2025

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Pre-T cell receptor-α immunodeficiency detected exclusively using whole genome sequencing.
Daniele Merico, Nigel Sharfe, Harjit Dadi, Bhooma Thiruvahindrapuram, Jill de Rijke

NPJ Genom Med· January 2025

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Novel immunodeficiency caused by homozygous mutation in solute carrier family 19 member 1, which encodes the reduced folate carrier.
Akira Shiraishi, Vedat Uygun, Nigel Sharfe, Serap Beldar, Mark G F Sun

Blood· June 2023

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NFκB pathway dysregulation due to reduced RelB expression leads to severe autoimmune disorders and declining immunity.
Nigel Sharfe, Ilan Dalal, Zahra Naghdi, Diane Lefaudeux, Linda Vong

J Autoimmun· May 2023

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Case Report: Eosinophilic Esophagitis in a Patient With a Novel STAT1 Gain-of-Function Pathogenic Variant.
Ori Scott, Nigel Sharfe, Harjit Dadi, Linda Vong, Jenny Garkaby

Front Immunol· March 2022

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Combined immunodeficiency caused by a novel homozygous NFKB1 mutation.
Amarilla B Mandola, Nigel Sharfe, Zahra Nagdi, Harjit Dadi, Linda Vong

J Allergy Clin Immunol· February 2021

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Defining the biological responses of IL-6 by the study of a novel IL-6 receptor chain immunodeficiency.
Amit Nahum, Nigel Sharfe, Arnon Broides, Harjit Dadi, Zahra Naghdi

J Allergy Clin Immunol· March 2020

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Dual loss of p110δ PI3-kinase and SKAP (KNSTRN) expression leads to combined immunodeficiency and multisystem syndromic features.
Nigel Sharfe, Ariana Karanxha, Harjit Dadi, Daniele Merico, David Chitayat

J Allergy Clin Immunol· August 2018

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Two different STAT1 gain-of-function mutations lead to diverse IFN-γ-mediated gene expression.
Adi Ovadia, Nigel Sharfe, Cynthia Hawkins, Suzanne Laughlin, Chaim M Roifman

NPJ Genom Med· August 2018

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Combined immunodeficiency and atopy caused by a dominant negative mutation in caspase activation and recruitment domain family member 11 (CARD11).
Harjit Dadi, Tyler A Jones, Daniele Merico, Nigel Sharfe, Adi Ovadia

J Allergy Clin Immunol· May 2018

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The effects of RelB deficiency on lymphocyte development and function.
Nigel Sharfe, Daniele Merico, Ariana Karanxha, Carly Macdonald, Harjit Dadi

J Autoimmun· December 2015

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Fatal combined immunodeficiency associated with heterozygous mutation in STAT1.
Nigel Sharfe, Amit Nahum, Andrea Newell, Harjit Dadi, Bo Ngan

J Allergy Clin Immunol· March 2014

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Characterization of ζ-associated protein, 70 kd (ZAP70)-deficient human lymphocytes.
Chaim M Roifman, Harjit Dadi, Raz Somech, Amit Nahum, Nigel Sharfe

J Allergy Clin Immunol· December 2010

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The EphB6 receptor cooperates with c-Cbl to regulate the behavior of breast cancer cells.
Luke Truitt, Tanya Freywald, John DeCoteau, Nigel Sharfe, Andrew Freywald

Cancer Res· February 2010

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Association of the lymphoid protein tyrosine phosphatase, R620W variant, with chronic mucocutaneous candidiasis.
Amit Nahum, Andrea Bates, Nigel Sharfe, Chaim M Roifman

J Allergy Clin Immunol· December 2008

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EphA and ephrin-A proteins regulate integrin-mediated T lymphocyte interactions.
Nigel Sharfe, Martina Nikolic, Lorand Cimpeon, Alison Van De Kratts, Andrew Freywald

Mol Immunol· March 2008

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Human T cell immunodeficiency: when signal transduction goes wrong.
Eyal Grunebaum, Nigel Sharfe, Chaim M Roifman

Immunol Res· October 2006

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EphA receptors inhibit anti-CD3-induced apoptosis in thymocytes.
Andrew Freywald, Nigel Sharfe, Charlotte D'E Miller, Cher Rashotte, Chaim M Roifman

J Immunol· April 2006

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Tyrenes: synthesis of new antiproliferative compounds with an extended conjugation.
Peter Demin, Olga Rounova, Thomas Grunberger, Lorand Cimpean, Nigel Sharfe

Bioorg Med Chem· June 2004

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Inhibition of acute lymphoblastic and myeloid leukemias by a novel kinase inhibitor.
Thomas Grunberger, Peter Demin, Olga Rounova, Nigel Sharfe, Lorand Cimpean

Blood· December 2003

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Ephrin-A1 induces c-Cbl phosphorylation and EphA receptor down-regulation in T cells.
Nigel Sharfe, Andrew Freywald, Ana Toro, Chaim M Roifman

J Immunol· June 2003

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The EphB6 receptor inhibits JNK activation in T lymphocytes and modulates T cell receptor-mediated responses.
Andrew Freywald, Nigel Sharfe, Cher Rashotte, Thomas Grunberger, Chaim M Roifman

J Biol Chem· March 2003

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Ephrin stimulation modulates T cell chemotaxis.
Nigel Sharfe, Andrew Freywald, Ana Toro, Harjit Dadi, Chaim Roifman

Eur J Immunol· December 2002

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The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1.
Andrew Freywald, Nigel Sharfe, Chaim M Roifman

J Biol Chem· February 2002

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