Publications by authors named "Nigulas Samel"

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Calorimetric approach for comparison of Angiopoietin-like protein 4 with other pancreatic lipase inhibitors.
Ly Villo, Robert Risti, Mart Reimund, Kaia Kukk, Nigulas Samel

Biochim Biophys Acta Mol Cell Biol Lipids· February 2020

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Distinct characteristics of the substrate binding between highly homologous catalase-related allene oxide synthase and hydroperoxide lyase.
Tarvi Teder, Nigulas Samel, Helike Lõhelaid

Arch Biochem Biophys· November 2019

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Gly188Arg substitution eliminates substrate inhibition in arachidonate 11R-lipoxygenase.
Kaspar Põldemaa, Maarja Lipp, Ivar Järving, Nigulas Samel, Priit Eek

Biochem Biophys Res Commun· October 2019

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Eicosanoid Diversity of Stony Corals.
Helike Lõhelaid, Nigulas Samel

Mar Drugs· January 2018

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A PDZ-like domain mediates the dimerization of 11R-lipoxygenase.
Priit Eek, Kaspar Põldemaa, Sergo Kasvandik, Ivar Järving, Nigulas Samel

Biochim Biophys Acta Mol Cell Biol Lipids· October 2017

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Structural and functional insights into the reaction specificity of catalase-related hydroperoxide lyase: A shift from lyase activity to allene oxide synthase by site-directed mutagenesis.
Tarvi Teder, Helike Lõhelaid, Nigulas Samel

PLoS One· October 2017

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Glucose impairs aspirin inhibition in platelets through a NAD(P)H oxidase signaling pathway.
Gennadi Kobzar, Vilja Mardla, Nigulas Samel

Prostaglandins Other Lipid Mediat· July 2017

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Enhanced expression of human prostaglandin H synthase-2 in the yeast Pichia pastoris and removal of the C-terminal tag with bovine carboxypeptidase A.
Kaia Kukk, Nigulas Samel

J Biotechnol· August 2016

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A conserved π-cation and an electrostatic bridge are essential for 11R-lipoxygenase catalysis and structural stability.
Priit Eek, Mari-Ann Piht, Margus Rätsep, Arvi Freiberg, Ivar Järving, Nigulas Samel

Biochim Biophys Acta· October 2015

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A Catalase-related Hemoprotein in Coral Is Specialized for Synthesis of Short-chain Aldehydes: DISCOVERY OF P450-TYPE HYDROPEROXIDE LYASE ACTIVITY IN A CATALASE.
Tarvi Teder, Helike Lõhelaid, William E Boeglin, Wade M Calcutt, Alan R Brash, Nigulas Samel

J Biol Chem· August 2015

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Lactate is a possible mediator of the glucose effect on platelet inhibition.
Gennadi Kobzar, Vilja Mardla, Nigulas Samel

Platelets· January 2015

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Up-regulated expression of AOS-LOXa and increased eicosanoid synthesis in response to coral wounding.
Helike Lõhelaid, Tarvi Teder, Kadri Tõldsepp, Merrick Ekins, Nigulas Samel

PLoS One· October 2014

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Novel membrane-associated prostaglandin E synthase-2 from crustacean arthropods.
Kristella Hansen, Külliki Varvas, Ivar Järving, Nigulas Samel

Comp Biochem Physiol B Biochem Mol Biol· August 2014

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N-glycosylation site occupancy in human prostaglandin H synthases expressed in Pichia pastoris.
Kaia Kukk, Sergo Kasvandik, Nigulas Samel

Springerplus· August 2014

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Structural and catalytic insights into the algal prostaglandin H synthase reveal atypical features of the first non-animal cyclooxygenase.
Külliki Varvas, Sergo Kasvandik, Kristella Hansen, Ivar Järving, Indrek Morell, Nigulas Samel

Biochim Biophys Acta· April 2013

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Purification and characterization of the recombinant human prostaglandin H synthase-2 expressed in Pichia pastoris.
Kaia Kukk, Reet Järving, Nigulas Samel

Protein Expr Purif· June 2012

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Structure of a calcium-dependent 11R-lipoxygenase suggests a mechanism for Ca2+ regulation.
Priit Eek, Reet Järving, Ivar Järving, Nathaniel C Gilbert, Marcia E Newcomer, Nigulas Samel

J Biol Chem· June 2012

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Activation of 11R-lipoxygenase is fully Ca(2+)-dependent and controlled by the phospholipid composition of the target membrane.
Reet Järving, Aivar Lõokene, Reet Kurg, Liina Siimon, Ivar Järving, Nigulas Samel

Biochemistry· April 2012

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Short-term exposure of platelets to glucose impairs inhibition of platelet aggregation by cyclooxygenase inhibitors.
Gennadi Kobzar, Vilja Mardla, Nigulas Samel

Platelets· December 2011

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Direct evidence of the cyclooxygenase pathway of prostaglandin synthesis in arthropods: genetic and biochemical characterization of two crustacean cyclooxygenases.
Külliki Varvas, Reet Kurg, Kristella Hansen, Reet Järving, Ivar Järving, Nigulas Samel

Insect Biochem Mol Biol· December 2009

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Effect of vitamin B(6) vitamers on platelet aggregation.
Gennadi Kobzar, Vilja Mardla, Indrek Rätsep, Nigulas Samel

Platelets· March 2009

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Identification of a functional allene oxide synthase-lipoxygenase fusion protein in the soft coral Gersemia fruticosa suggests the generality of this pathway in octocorals.
Helike Lõhelaid, Reet Järving, Karin Valmsen, Külliki Varvas, Malle Kreen, Nigulas Samel

Biochim Biophys Acta· February 2008

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A critical role of non-active site residues on cyclooxygenase helices 5 and 6 in the control of prostaglandin stereochemistry at carbon 15.
Karin Valmsen, William E Boeglin, Reet Järving, Ivar Järving, Külliki Varvas, Nigulas Samel

J Biol Chem· September 2007

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Platelet activity before and after coronary artery bypass grafting.
Gennadi Kobzar, Vilja Mardla, Indrek Rätsep, Nigulas Samel

Platelets· August 2006

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Identification and characterization of an arachidonate 11R-lipoxygenase.
Monika Mortimer, Reet Järving, Alan R Brash, Nigulas Samel, Ivar Järving

Arch Biochem Biophys· January 2006

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