Publications by authors named "Nigus D Ambaye"

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Novel anti-cancer candidates from a combinatorial peptide library.
Nigus D Ambaye, Hua E Yu

Chem Biol Drug Des· January 2021

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Noncovalent structure of SENP1 in complex with SUMO2.
Nigus D Ambaye

Acta Crystallogr F Struct Biol Commun· May 2019

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Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction.
Marcelo L Actis, Nigus D Ambaye, Benjamin J Evison, Youming Shao, Murugendra Vanarotti

Bioorg Med Chem· September 2016

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Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
Menachem J Gunzburg, Ketav Kulkarni, Gabrielle M Watson, Nigus D Ambaye, Mark P Del Borgo

Sci Rep· June 2016

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Observation of an E2 (Ubc9)-homodimer by crystallography.
Aileen Y Alontaga, Nigus D Ambaye, Yi-Jia Li, Ramir Vega, Chih-Hong Chen

Data Brief· June 2016

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Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target.
Gabrielle M Watson, Menachem J Gunzburg, Nigus D Ambaye, William A H Lucas, Daouda A Traore

J Med Chem· October 2015

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RWD Domain as an E2 (Ubc9)-Interaction Module.
Aileen Y Alontaga, Nigus D Ambaye, Yi-Jia Li, Ramir Vega, Chih-Hong Chen

J Biol Chem· July 2015

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Preparation of crystals for characterizing the Grb7 SH2 domain before and after complex formation with a bicyclic peptide antagonist.
Nigus D Ambaye, Menachem J Gunzburg, Daouda A K Traore, Mark P Del Borgo, Patrick Perlmutter

Acta Crystallogr F Struct Biol Commun· February 2014

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Design and testing of bicyclic inhibitors of Grb7--are two cycles better than one?
Menachem J Gunzburg, Nigus D Ambaye, Mark P Del Borgo, Patrick Perlmutter, Jacqueline A Wilce

Biopolymers· September 2013

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The discovery of phenylbenzamide derivatives as Grb7-based antitumor agents.
Nigus D Ambaye, Menachem J Gunzburg, Reece C C Lim, John T Price, Matthew C J Wilce

ChemMedChem· February 2013

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Interaction of the non-phosphorylated peptide G7-18NATE with Grb7-SH2 domain requires phosphate for enhanced affinity and specificity.
Menachem J Gunzburg, Nigus D Ambaye, Mark P Del Borgo, Stephanie C Pero, David N Krag

J Mol Recognit· January 2012

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Structural basis of binding by cyclic nonphosphorylated peptide antagonists of Grb7 implicated in breast cancer progression.
Nigus D Ambaye, Stephanie C Pero, Menachem J Gunzburg, MinYin Yap, Daniel J Clayton

J Mol Biol· September 2011

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Uptake of a cell permeable G7-18NATE contruct into cells and binding with the Grb-7-SH2 domain.
Nigus D Ambaye, Reece C C Lim, Daniel J Clayton, Menachem J Gunzburg, John T Price

Biopolymers· July 2011

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Benzopyrazine derivatives: A novel class of growth factor receptor bound protein 7 antagonists.
Nigus D Ambaye, Menachem J Gunzburg, Reece C C Lim, John T Price, Matthew C J Wilce

Bioorg Med Chem· January 2011

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