Publications by authors named "Nikhil M Urs"

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Enhanced cognitive flexibility and phasic striatal dopamine dynamics in a mouse model of low striatal tonic dopamine.
Jena Delaney, Sanya Nathani, Victor Tan, Carson Chavez, Alexander Orr, Nikhil M Urs

Neuropsychopharmacology· September 2024

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Locus coeruleus injury modulates ventral midbrain neuroinflammation during DSS-induced colitis.
Jake Sondag Boles, Jenny Holt, Cassandra L Cole, Noelle K Neighbarger, Nikhil M Urs

bioRxiv· February 2024

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Computational insights into ligand-induced G protein and β-arrestin signaling of the dopamine D1 receptor.
Haoxi Li, Nikhil M Urs, Nicole Horenstein

J Comput Aided Mol Des· June 2023

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Measuring Nonapoptotic Caspase Activity with a Transgenic Reporter in Mice.
P J Nicholls, Thomas F Pack, Nikhil M Urs, Sunil Kumar, Yang Zhou

eNeuro· January 2023

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Structure-Functional Selectivity Relationship Studies on A-86929 Analogs and Small Aryl Fragments toward the Discovery of Biased Dopamine D1 Receptor Agonists.
Haoxi Li, Rosa Mirabel, Joseph Zimmerman, Ion Ghiviriga, Darian K Phidd, Nikhil M Urs

ACS Chem Neurosci· June 2022

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A role for cortical dopamine in the paradoxical calming effects of psychostimulants.
Sharonda S Harris, Sara M Green, Mayank Kumar, Nikhil M Urs

Sci Rep· February 2022

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Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo.
Laura M Vecchio, Patricia Sullivan, Amy R Dunn, Marie Kristel Bermejo, Rong Fu, Nikhil M Urs

J Neurochem· August 2021

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Retrograde Labeling Illuminates Distinct Topographical Organization of D1 and D2 Receptor-Positive Pyramidal Neurons in the Prefrontal Cortex of Mice.
Sara M Green, Sanya Nathani, Joseph Zimmerman, David Fireman, Nikhil M Urs

eNeuro· June 2021

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Targeting β-Arrestins in the Treatment of Psychiatric and Neurological Disorders.
Sharonda S Harris, Nikhil M Urs

CNS Drugs· March 2021

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Loss of β-arrestin2 in D2 cells alters neuronal excitability in the nucleus accumbens and behavioral responses to psychostimulants and opioids.
Kirsten A Porter-Stransky, Alyssa K Petko, Saumya L Karne, L Cameron Liles, Nikhil M Urs

Addict Biol· November 2020

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Deletion of Glycogen Synthase Kinase-3β in D Receptor-Positive Neurons Ameliorates Cognitive Impairment via NMDA Receptor-Dependent Synaptic Plasticity.
Yan-Chun Li, Priyalakshmi Panikker, Bo Xing, Sha-Sha Yang, Cassandra Alexandropoulos, Nikhil M Urs

Biol Psychiatry· April 2020

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Structure-Functional-Selectivity Relationship Studies of Novel Apomorphine Analogs to Develop D1R/D2R Biased Ligands.
Hyejin Park, Aarti N Urs, Joseph Zimmerman, Chuan Liu, Qiu Wang, Nikhil M Urs

ACS Med Chem Lett· March 2020

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Slow-release delivery enhances the pharmacological properties of oral 5-hydroxytryptophan: mouse proof-of-concept.
Jacob P R Jacobsen, Adrianna Oh, Rachel Bangle, Wendy L Roberts, Elizabeth L Royer, Nikhil M Urs

Neuropsychopharmacology· November 2019

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Methods to Investigate the Role of β-Arrestin Signaling in Parkinson's Disease.
Nikhil M Urs

Methods Mol Biol· July 2019

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Ghrelin receptor antagonism of hyperlocomotion in cocaine-sensitized mice requires βarrestin-2.
Krisztian Toth, Lauren M Slosky, Thomas F Pack, Nikhil M Urs, Peter Boone

Synapse· January 2018

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Hepatic β-arrestin 2 is essential for maintaining euglycemia.
Lu Zhu, Mario Rossi, Yinghong Cui, Regina J Lee, Wataru Sakamoto, Nikhil M Urs

J Clin Invest· August 2017

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β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions.
Lu Zhu, Joana Almaça, Prasanna K Dadi, Hao Hong, Wataru Sakamoto, Nikhil M Urs

Nat Commun· February 2017

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New Concepts in Dopamine D Receptor Biased Signaling and Implications for Schizophrenia Therapy.
Nikhil M Urs, Sean M Peterson, Marc G Caron

Biol Psychiatry· January 2017

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Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties.
Nikhil M Urs, Steven M Gee, Thomas F Pack, John D McCorvy, Tama Evron

Proc Natl Acad Sci U S A· December 2016

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ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse.
Larry S Barak, Yushi Bai, Sean Peterson, Tama Evron, Nikhil M Urs

ACS Chem Biol· July 2016

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Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor.
Sean M Peterson, Thomas F Pack, Angela D Wilkins, Nikhil M Urs, Daniel J Urban

Proc Natl Acad Sci U S A· June 2015

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Targeting β-arrestin2 in the treatment of L-DOPA-induced dyskinesia in Parkinson's disease.
Nikhil M Urs, Simone Bido, Sean M Peterson, Tanya L Daigle, Caroline E Bass

Proc Natl Acad Sci U S A· May 2015

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G Protein and β-arrestin signaling bias at the ghrelin receptor.
Tama Evron, Sean M Peterson, Nikhil M Urs, Yushi Bai, Lauren K Rochelle

J Biol Chem· November 2014

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Selective deletion of GRK2 alters psychostimulant-induced behaviors and dopamine neurotransmission.
Tanya L Daigle, Mark J Ferris, Raul R Gainetdinov, Tatyana D Sotnikova, Nikhil M Urs

Neuropsychopharmacology· September 2014

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Integrated approaches to understanding antipsychotic drug action at GPCRs.
Nikhil M Urs, Peter J Nicholls, Marc G Caron

Curr Opin Cell Biol· April 2014

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