Publications by authors named "Nikhil Panicker"

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Sterile Innate Immune Mechanisms in Neurodegenerative diseases.
Alyssa Ealy, Amanda M Serapiglia, Nikhil Panicker

J Biol Chem· December 2025

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Poly(ADP-ribose) Polymerase 1 Deficiency Attenuates Amyloid Pathology, Neurodegeneration, and Cognitive Decline in a Familial Alzheimer's Disease Model.
Aanishaa Jhaldiyal, Manisha Kumari, Trupti Tripathi, Mohammed Repon Khan, Justin Wang, Nikhil Panicker

bioRxiv· September 2025

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Inflammasome assembly in neurodegenerative diseases.
Jagjit Singh, Maria L Habean, Nikhil Panicker

Trends Neurosci· October 2023

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Cell Biology of Parkin: Clues to the Development of New Therapeutics for Parkinson's Disease.
Jaimin Patel, Nikhil Panicker, Valina L Dawson, Ted M Dawson

CNS Drugs· December 2022

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Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease.
Nikhil Panicker, Tae-In Kam, Hu Wang, Stewart Neifert, Shih-Ching Chou

Neuron· August 2022

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Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson's disease.
Sheila K Pirooznia, Hu Wang, Nikhil Panicker, Manoj Kumar, Stewart Neifert

Sci Adv· April 2022

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STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy.
Jared T Hinkle, Jaimin Patel, Nikhil Panicker, Senthilkumar S Karuppagounder, Devanik Biswas

Proc Natl Acad Sci U S A· April 2022

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The cell biology of Parkinson's disease.
Nikhil Panicker, Preston Ge, Valina L Dawson, Ted M Dawson

J Cell Biol· April 2021

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Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: Relevance to translational research.
Hariharan Saminathan, Adhithiya Charli, Jie Luo, Nikhil Panicker, Richard Gordon

Eur J Pharmacol· August 2020

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Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease.
Souvarish Sarkar, Hai M Nguyen, Emir Malovic, Jie Luo, Monica Langley, Nikhil Panicker

J Clin Invest· August 2020

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Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease.
Sangjune Kim, Seung-Hwan Kwon, Tae-In Kam, Nikhil Panicker, Senthilkumar S Karuppagounder

Neuron· August 2019

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Fyn amplifies NLRP3 inflammasome signaling in Parkinson's disease.
Nikhil Panicker, Arthi Kanthasamy, Anumantha G Kanthasamy

Aging (Albany NY)· August 2019

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Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia.
Nikhil Panicker, Souvarish Sarkar, Dilshan S Harischandra, Matthew Neal, Tae-In Kam

J Exp Med· June 2019

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Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein.
Dilshan S Harischandra, Dharmin Rokad, Matthew L Neal, Shivani Ghaisas, Sireesha Manne, Nikhil Panicker

Sci Signal· March 2019

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Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease.
Tae-In Kam, Xiaobo Mao, Hyejin Park, Shih-Ching Chou, Senthilkumar S Karuppagounder, Nikhil Panicker

Science· November 2018

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Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease.
Seung Pil Yun, Tae-In Kam, Nikhil Panicker, SangMin Kim, Yumin Oh

Nat Med· July 2018

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Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease.
Souvarish Sarkar, Emir Malovic, Dilshan S Harishchandra, Shivani Ghaisas, Nikhil Panicker

NPJ Parkinsons Dis· October 2017

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Activation mechanisms of the E3 ubiquitin ligase parkin.
Nikhil Panicker, Valina L Dawson, Ted M Dawson

Biochem J· August 2017

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Neurotoxic reactive astrocytes are induced by activated microglia.
Shane A Liddelow, Kevin A Guttenplan, Laura E Clarke, Frederick C Bennett, Christopher J Bohlen, Nikhil Panicker

Nature· January 2017

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Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration.
Richard Gordon, Matthew L Neal, Jie Luo, Monica R Langley, Dilshan S Harischandra, Nikhil Panicker

Nat Commun· October 2016

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Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease.
Richard Gordon, Neeraj Singh, Vivek Lawana, Anamitra Ghosh, Dilshan S Harischandra, Nikhil Panicker

Neurobiol Dis· September 2016

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Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3.
Xiaobo Mao, Michael Tianhao Ou, Senthilkumar S Karuppagounder, Tae-In Kam, Xiling Yin, Nikhil Panicker

Science· September 2016

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Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease.
Nikhil Panicker, Hariharan Saminathan, Huajun Jin, Matthew Neal, Dilshan S Harischandra

J Neurosci· July 2015

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Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease.
Huajun Jin, Arthi Kanthasamy, Dilshan S Harischandra, Naveen Kondru, Anamitra Ghosh, Nikhil Panicker

J Biol Chem· December 2014

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