Publications by authors named "Nirmal Parajuli"

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MicroRNA-17-92 Regulates Skin Langerhans Cell Embryonic Development by Targeting Cell Proliferation Pathways.
Nirmal Parajuli, Qiyan Wang, Jie Wang, Congcong Yin, Kalpana Subedi

J Invest Dermatol· December 2025

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Unveiling the therapeutic potential of artopetelin flavonoids through computational approaches as peroxisome proliferator-activated receptor-delta (PPARδ) agonists.
Ram Lal Swagat Shrestha, Ashika Tamang, Manila Poudel, M C Shiva, Nirmal Parajuli

J Mol Graph Model· November 2025

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AI-assisted discovery of potent FGFR1 inhibitors via virtual screening and in silico analysis.
Ram Lal Swagat Shrestha, Ashika Tamang, Sandeep Poudel Chhetri, Nirmal Parajuli, Manila Poudel

PLoS One· September 2025

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MicroRNAs regulate alveolar macrophage homeostasis and its function in lung fibrosis.
Nirmal Parajuli, Yi Yao, Namir Khalasawi, Congcong Yin, Qiong Zhang

Front Immunol· July 2025

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Evaluating the inhibitory efficacy of Oxalis phytocompounds on monoamine oxidase B: An integrated approach targeting age related neurodegenerative diseases through molecular docking and dynamics simulations.
Ram Lal Swagat Shrestha, Shiva M C, Ashika Tamang, Manila Poudel, Nirmal Parajuli

PLoS One· July 2025

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Correction: Computational approach for the evaluation of sesquiterpene lactone as a modulator of cannabinoid receptor type 2 for neurodegenerative disease prophylactics.
Ram Lal Swagat Shrestha, Ashika Tamang, Sujan Dhital, Nirmal Parajuli, Manila Poudel

Mol Divers· May 2025

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Computational approach for the evaluation of sesquiterpene lactone as a modulator of cannabinoid receptor type 2 for neurodegenerative disease prophylactics.
Ram Lal Swagat Shrestha, Ashika Tamang, Sujan Dhital, Nirmal Parajuli, Manila Poudel

Mol Divers· April 2025

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Epigenetic Control of Alveolar Macrophages: Impact on Lung Health and Disease.
Nirmal Parajuli, Kalpana Subedi, Xzaviar Kaymar Solone, Aimin Jiang, Li Zhou

Cells· April 2025

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S14-Phosphorylated RPN6 Mediates Proteasome Activation by PKA and Alleviates Proteinopathy.
Liuqing Yang, Nirmal Parajuli, Penglong Wu, Jinbao Liu, Xuejun Wang

Circ Res· September 2023

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MiR-23a Regulates Skin Langerhans Cell Phagocytosis and Inflammation-Induced Langerhans Cell Repopulation.
Jie Wang, Nirmal Parajuli, Qiyan Wang, Namir Khalasawi, Hongmei Peng

Biology (Basel)· June 2023

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Ser14-RPN6 Phosphorylation Mediates the Activation of 26S Proteasomes by cAMP and Protects against Cardiac Proteotoxic Stress in Mice.
Liuqing Yang, Nirmal Parajuli, Penglong Wu, Jinbao Liu, Xuejun Wang

bioRxiv· April 2023

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Editorial: Oxidative Stress in Cardiovascular Diseases and Pulmonary Hypertension.
Nirmal Parajuli, Djuro Kosanovic

Front Cardiovasc Med· March 2022

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ALK3 Is Not Required for the Embryonic Development, Homeostasis, and Repopulation of Epidermal Langerhans Cells in Steady and Inflammatory States.
Qian Yu, Nirmal Parajuli, Qijun Yi, Yuji Mishina, James T Elder

J Invest Dermatol· July 2021

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Smad2/4 Signaling Pathway Is Critical for Epidermal Langerhans Cell Repopulation Under Inflammatory Condition but Not Required for Their Homeostasis at Steady State.
Linting Huang, Gui-Hua Li, Qian Yu, Yingping Xu, Steven Cvetkovski, Nirmal Parajuli

Front Immunol· April 2021

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The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction.
Bo Pan, Jie Li, Nirmal Parajuli, Zongwen Tian, Penglong Wu

Circ Res· July 2020

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Author Correction: NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD.
Michael Seimetz, Natascha Sommer, Mariola Bednorz, Oleg Pak, Christine Veith, Nirmal Parajuli

Nat Metab· July 2020

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NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD.
Michael Seimetz, Natascha Sommer, Mariola Bednorz, Oleg Pak, Christine Veith, Nirmal Parajuli

Nat Metab· June 2020

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Empagliflozin Blunts Worsening Cardiac Dysfunction Associated With Reduced NLRP3 (Nucleotide-Binding Domain-Like Receptor Protein 3) Inflammasome Activation in Heart Failure.
Nikole J Byrne, Nobutoshi Matsumura, Zaid H Maayah, Mourad Ferdaoussi, Shingo Takahara, Nirmal Parajuli

Circ Heart Fail· January 2020

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PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy.
Hanming Zhang, Bo Pan, Penglong Wu, Nirmal Parajuli, Mark D Rekhter

Sci Adv· May 2019

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Resveratrol improves cardiac function and exercise performance in MI-induced heart failure through the inhibition of cardiotoxic HETE metabolites.
Nobutoshi Matsumura, Shingo Takahara, Zaid H Maayah, Nirmal Parajuli, Nikole J Byrne

J Mol Cell Cardiol· December 2018

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Fecal transplant from resveratrol-fed donors improves glycaemia and cardiovascular features of the metabolic syndrome in mice.
Ty T Kim, Nirmal Parajuli, Miranda M Sung, Suresh C Bairwa, Jody Levasseur

Am J Physiol Endocrinol Metab· October 2018

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Atglistatin ameliorates functional decline in heart failure via adipocyte-specific inhibition of adipose triglyceride lipase.
Nirmal Parajuli, Shingo Takahara, Nobutoshi Matsumura, Ty T Kim, Mourad Ferdaoussi

Am J Physiol Heart Circ Physiol· October 2018

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Co-administration of resveratrol with doxorubicin in young mice attenuates detrimental late-occurring cardiovascular changes.
Nobutoshi Matsumura, Beshay N Zordoky, Ian M Robertson, Shereen M Hamza, Nirmal Parajuli

Cardiovasc Res· August 2018

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Empagliflozin Prevents Worsening of Cardiac Function in an Experimental Model of Pressure Overload-Induced Heart Failure.
Nikole J Byrne, Nirmal Parajuli, Jody L Levasseur, Jamie Boisvenue, Donna L Beker

JACC Basic Transl Sci· August 2017

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The role of AMPK in cardiomyocyte health and survival.
Suresh C Bairwa, Nirmal Parajuli, Jason R B Dyck

Biochim Biophys Acta· December 2016

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