Publications by authors named "Noboru Hayama"

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Synthesis of the Abiraterone Derivatives 5α- and 5β-Δ-Abiraterone and Structural Determination of an Unknown Metabolite in Human Serum Derived from Oral Abiraterone Acetate.
Noboru Hayama, Shizuyo Horiyama, Ryoma Okamoto, Yukina Nishi, Manae Yada

Chembiochem· December 2025

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Synthesis of 5-Hydroxy-5-vinyl-2-cyclopentenones, a Family of Rare-Type Natural Products Mostly Recovered from Marine Sources.
Yoshihide Usami, Natsuki Asada, Chihiro Shizuma, Karin Negoro, Ryosuke Kawai, Noboru Hayama

Mar Drugs· November 2025

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Identification of novel metabolites of abiraterone in human serum and their metabolic pathways.
Shizuyo Horiyama, Noboru Hayama, Hiroki Yoneyama, Yoshihide Usami, Jun Haginaka

Anal Sci· January 2024

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[Asymmetric Hetero-Michael Additions to α,β-Unsaturated Carboxylic Acids by Multifunctional Boronic Acid Catalysts].
Noboru Hayama

Yakugaku Zasshi· June 2021

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CuI-Catalyzed Coupling Reactions of 4-Iodopyrazoles and Alcohols: Application toward Withasomnine and Homologs.
Yoshihide Usami, Yumika Kubo, Toshiki Takagaki, Nao Kuroiwa, Jun Ono, Noboru Hayama

Molecules· June 2021

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A solvent-dependent chirality-switchable thia-Michael addition to α,β-unsaturated carboxylic acids using a chiral multifunctional thiourea catalyst.
Noboru Hayama, Yusuke Kobayashi, Eriko Sekimoto, Anna Miyazaki, Kiyofumi Inamoto

Chem Sci· June 2020

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Inhibition of angiogenesis and tumor growth by a novel 1,4-naphthoquinone derivative.
Hiroko Murota, Tomohiro Shinya, Arisa Nishiuchi, Mariko Sakanaka, Ken-Ichi Toda, Noboru Hayama

Drug Dev Res· May 2019

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Catalytic asymmetric aza-Michael addition of fumaric monoacids with multifunctional thiourea/boronic acids.
Kenichi Michigami, Hiroki Murakami, Takeru Nakamura, Noboru Hayama, Yoshiji Takemoto

Org Biomol Chem· February 2019

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Mechanistic Insight into Asymmetric Hetero-Michael Addition of α,β-Unsaturated Carboxylic Acids Catalyzed by Multifunctional Thioureas.
Noboru Hayama, Ryuta Kuramoto, Tamás Földes, Kazuya Nishibayashi, Yusuke Kobayashi

J Am Chem Soc· September 2018

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Chiral Integrated Catalysts Composed of Bifunctional Thiourea and Arylboronic Acid: Asymmetric Aza-Michael Addition of α,β-Unsaturated Carboxylic Acids.
Noboru Hayama, Takumi Azuma, Yusuke Kobayashi, Yoshiji Takemoto

Chem Pharm Bull (Tokyo)· January 2017

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A powerful hydrogen-bond-donating organocatalyst for the enantioselective intramolecular oxa-Michael reaction of α,β-unsaturated amides and esters.
Yusuke Kobayashi, Yamato Taniguchi, Noboru Hayama, Tsubasa Inokuma, Yoshiji Takemoto

Angew Chem Int Ed Engl· October 2013

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One-pot construction of multiple contiguous chiral centers using Michael addition of chiral amine.
Minoru Ozeki, Shunsuke Ochi, Noboru Hayama, Shinzo Hosoi, Tetsuya Kajimoto

J Org Chem· June 2010

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