Publications by authors named "Nobuo Cho"

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Second-Generation AUTACs for Targeted Autophagic Degradation.
Daiki Takahashi, Taiichi Ora, Shigekazu Sasaki, Naoki Ishii, Toshio Tanaka, Nobuo Cho

J Med Chem· September 2023

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Synthesis of SNIPERs against BCR-ABL with kinase inhibitors and a method to evaluate their growth inhibitory activity derived from BCR-ABL degradation.
Nobuo Cho, Mikihiko Naito

Methods Enzymol· February 2023

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New antimalarials identified by a cell-based phenotypic approach: Structure-activity relationships of 2,3,4,9-tetrahydro-1H-β-carboline derivatives possessing a 2-((coumarin-5-yl)oxy)alkanoyl moiety.
Nobuo Cho, Ko Kikuzato, Yushi Futamura, Takeshi Shimizu, Hiroki Hayase

Bioorg Med Chem· July 2022

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Development of a degrader against oncogenic fusion protein FGFR3-TACC3.
Norihito Shibata, Nobuo Cho, Hiroo Koyama, Mikihiko Naito

Bioorg Med Chem Lett· March 2022

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Discovery of phenylpyrrolidine derivatives as a novel class of retinol binding protein 4 (RBP4) reducers.
Shinji Nakamura, Masahiro Kamaura, Yuichiro Akao, Natsuko Nakamura, Atsushi Mizukami, Nobuo Cho

Bioorg Med Chem· January 2022

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Discovery and Structure-Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials.
Benoît Laleu, Yuichiro Akao, Atsuko Ochida, Sandra Duffy, Leonardo Lucantoni, Nobuo Cho

J Med Chem· September 2021

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Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-]pyrimidinone-Based Cdc7 Inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Antitumor Agent.
Osamu Kurasawa, Tohru Miyazaki, Misaki Homma, Yuya Oguro, Takashi Imada, Nobuo Cho

J Med Chem· February 2020

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Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor.
Kenichi Iwai, Tadahiro Nambu, Ryo Dairiki, Momoko Ohori, Jie Yu, Nobuo Cho

Sci Adv· May 2019

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Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER).
Nobumichi Ohoka, Osamu Ujikawa, Kenichiro Shimokawa, Tomoya Sameshima, Norihito Shibata, Nobuo Cho

Chem Pharm Bull (Tokyo)· March 2019

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Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase.
Norihito Shibata, Kenichiro Shimokawa, Katsunori Nagai, Nobumichi Ohoka, Takayuki Hattori, Nobuo Cho

Sci Rep· September 2018

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Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation.
Nobumichi Ohoka, Yoko Morita, Katsunori Nagai, Kenichiro Shimokawa, Osamu Ujikawa, Nobuo Cho

J Biol Chem· May 2018

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Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands.
Norihito Shibata, Katsunori Nagai, Yoko Morita, Osamu Ujikawa, Nobumichi Ohoka, Nobuo Cho

J Med Chem· January 2018

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Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation.
Kenichiro Shimokawa, Norihito Shibata, Tomoya Sameshima, Naoki Miyamoto, Osamu Ujikawa, Nobuo Cho

ACS Med Chem Lett· October 2017

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Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands.
Norihito Shibata, Naoki Miyamoto, Katsunori Nagai, Kenichiro Shimokawa, Tomoya Sameshima, Nobuo Cho

Cancer Sci· August 2017

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2-Aminomethylthieno[3,2-d]pyrimidin-4(3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase.
Osamu Kurasawa, Misaki Homma, Yuya Oguro, Tohru Miyazaki, Kouji Mori, Nobuo Cho

Bioorg Med Chem· July 2017

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SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib.
Nobumichi Ohoka, Katsunori Nagai, Norihito Shibata, Takayuki Hattori, Hiroshi Nara, Nobuo Cho

Cancer Sci· May 2017

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Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones.
Osamu Kurasawa, Yuya Oguro, Tohru Miyazaki, Misaki Homma, Kouji Mori, Nobuo Cho

Bioorg Med Chem· April 2017

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K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology.
Kotaro Sakamoto, Yusuke Kamada, Tomoya Sameshima, Masahiro Yaguchi, Ayumu Niida, Nobuo Cho

Biochem Biophys Res Commun· March 2017

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Knockdown of Pathogenic Proteins via pecific and ongenetic nhibitor of Apoptosis Protein (IAP)-dependent rotein asers (SNIPERs).
Nobumichi Ohoka, Keiichiro Okuhira, Masahiro Ito, Katsunori Nagai, Norihito Shibata, Nobuo Cho

J Biol Chem· March 2017

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Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.
Yuta Tanaka, Katsuji Aikawa, Goushi Nishida, Misaki Homma, Satoshi Sogabe, Nobuo Cho

J Med Chem· December 2013

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Peroxisome proliferator-activated receptor gamma agonists as insulin sensitizers: from the discovery to recent progress.
Nobuo Cho, Yu Momose

Curr Top Med Chem· February 2009

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Design, synthesis, and structure-activity relationships of thieno[2,3-b]pyridin-4-one derivatives as a novel class of potent, orally active, non-peptide luteinizing hormone-releasing hormone receptor antagonists.
Takashi Imada, Nobuo Cho, Toshihiro Imaeda, Yoji Hayase, Satoshi Sasaki

J Med Chem· June 2006

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Suppression of a pituitary-ovarian axis by chronic oral administration of a novel nonpeptide gonadotropin-releasing hormone antagonist, TAK-013, in cynomolgus monkeys.
Takahito Hara, Hideo Araki, Masami Kusaka, Masataka Harada, Nobuo Cho

J Clin Endocrinol Metab· April 2003

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Discovery of a thieno[2,3-d]pyrimidine-2,4-dione bearing a p-methoxyureidophenyl moiety at the 6-position: a highly potent and orally bioavailable non-peptide antagonist for the human luteinizing hormone-releasing hormone receptor.
Satoshi Sasaki, Nobuo Cho, Yoshi Nara, Masataka Harada, Satoshi Endo

J Med Chem· January 2003

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A new class of potent nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists: design and synthesis of 2-phenylimidazo[1,2-a]pyrimidin-5-ones.
Satoshi Sasaki, Toshihiro Imaeda, Yoji Hayase, Yoshiaki Shimizu, Shizuo Kasai, Nobuo Cho

Bioorg Med Chem Lett· August 2002

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