Publications by authors named "Nobutaka Numoto"

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Structural basis of affinity maturation of anti-(4-hydroxy-3-nitrophenyl)acetyl antibodies.
Mutsumi Yoshida, Yuya Hanazono, Nobutaka Numoto, Saaya Yabuno, Nobutoshi Ito

Arch Biochem Biophys· January 2026

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A Unique Trimeric Assembly of Human Dishevelled 1 PDZ Domain in Crystal: Implication of Homo- and Hetero-Oligomerization During Wnt Signaling Process.
Shotaro Yasukochi, Nobutaka Numoto, Kiminori Hori, Takeshi Tenno, Emi Hibino

Molecules· August 2025

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Crystal structures reveal how the multispecific antibody G2 achieves binding to different peptides.
Yuya Hanazono, Saaya Yabuno, Takahiro Hayashi, Nobutaka Numoto, Yuji O Kamatari

FEBS Lett· June 2025

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Structure-activity relationship of PET-degrading cutinase regulated by weak Ca binding and temperature.
Fumiya Kondo, Narutoshi Kamiya, Gert-Jan Bekker, Satoshi Nagao, Nobutaka Numoto

Biophys Physicobiol· April 2025

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Open and closed structures of L-arginine oxidase by cryo-electron microscopy and X-ray crystallography.
Hiroki Yamaguchi, Kazutoshi Takahashi, Nobutaka Numoto, Hiroshi Suzuki, Moemi Tatsumi

J Biochem· January 2025

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Structure-guided engineering of a mutation-tolerant inhibitor peptide against variable SARS-CoV-2 spikes.
Shun Nakamura, Yukihiro Tanimura, Risa Nomura, Hiroshi Suzuki, Kouki Nishikawa, Nobutaka Numoto

Proc Natl Acad Sci U S A· January 2025

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Structural basis for the full and partial agonist activities of retinoid X receptor α ligands with an iso-butoxy and an isopropyl group.
Daisuke Imai, Nobutaka Numoto, Hiroaki Tokiwa, Hiroki Kakuta, Nobutoshi Ito

Biochem Biophys Res Commun· November 2024

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Structural dynamics of the Ca-regulated cutinase towards structure-based improvement of PET degradation activity.
Nobutaka Numoto, Fumiya Kondo, Gert-Jan Bekker, Zengwei Liao, Mitsuaki Yamashita

Int J Biol Macromol· November 2024

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Affinity-matured antibody with a disulfide bond in H-CDR3 loop.
Mutsumi Yoshida, Yuya Hanazono, Nobutaka Numoto, Satoshi Nagao, Saaya Yabuno

Arch Biochem Biophys· August 2024

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CD72 is an inhibitory pattern recognition receptor that recognizes ribosomes and suppresses production of anti-ribosome autoantibody.
Chizuru Akatsu, Takahiro Tsuneshige, Nobutaka Numoto, Wang Long, Toshio Uchiumi

J Autoimmun· June 2024

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Elucidation of binding mechanism, affinity, and complex structure between mWT1 tumor-associated antigen peptide and HLA-A*24:02.
Gert-Jan Bekker, Nobutaka Numoto, Maki Kawasaki, Takahiro Hayashi, Saaya Yabuno

Protein Sci· October 2023

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Structural analysis of the water channel AQP2 by single-particle cryo-EM.
Akiko Kamegawa, Shota Suzuki, Hiroshi Suzuki, Kouki Nishikawa, Nobutaka Numoto

J Struct Biol· September 2023

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Recognition Mechanism of a Novel Gabapentinoid Drug, Mirogabalin, for Recombinant Human αδ1, a Voltage-Gated Calcium Channel Subunit.
Daisuke Kozai, Nobutaka Numoto, Kouki Nishikawa, Akiko Kamegawa, Shohei Kawasaki

J Mol Biol· May 2023

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Structures of oxygen dissociation intermediates of 400 kDa V2 hemoglobin provide coarse snapshots of the protein allostery.
Nobutaka Numoto, Seiko Onoda, Yoshiaki Kawano, Hideo Okumura, Seiki Baba

Biophys Physicobiol· May 2022

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Varying the Directionality of Protein Catalysts for Aldol and Retro-Aldol Reactions.
Toshifumi Fujioka, Nobutaka Numoto, Hiroyuki Akama, Kola Shilpa, Michiko Oka

Chembiochem· January 2022

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Lithocholic Acid Amides as Potent Vitamin D Receptor Agonists.
Ayana Yoshihara, Haru Kawasaki, Hiroyuki Masuno, Koki Takada, Nobutaka Numoto

Biomolecules· January 2022

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Coarse snapshots of oxygen-dissociation intermediates of a giant hemoglobin elucidated by determining the oxygen saturation in individual subunits in the crystalline state.
Nobutaka Numoto, Yoshiaki Kawano, Hideo Okumura, Seiki Baba, Yoshihiro Fukumori

IUCrJ· November 2021

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Cutinases from thermophilic bacteria (actinomycetes): From identification to functional and structural characterization.
Masayuki Oda, Nobutaka Numoto, Gert-Jan Bekker, Narutoshi Kamiya, Fusako Kawai

Methods Enzymol· June 2021

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Structural basis of mutants of PET-degrading enzyme from Saccharomonospora viridis AHK190 with high activity and thermal stability.
Miho Emori, Nobutaka Numoto, Akane Senga, Gert-Jan Bekker, Narutoshi Kamiya

Proteins· May 2021

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Multiple structural states of Ca2+-regulated PET hydrolase, Cut190, and its correlation with activity and stability.
Akane Senga, Nobutaka Numoto, Mitsuaki Yamashita, Akira Iida, Nobutoshi Ito

J Biochem· March 2021

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Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains.
Momoka Iiyama, Nobutaka Numoto, Shuhei Ogawa, Masataka Kuroda, Hisayuki Morii

Mol Immunol· March 2021

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A Guillain-Barré syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides.
Amin Alborzian Deh Sheikh, Soha Gomaa, Xuexin Li, Matthew Routledge, Kazumasa Saigoh, Nobutaka Numoto

J Autoimmun· January 2021

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Lithocholic Acid Derivatives as Potent Vitamin D Receptor Agonists.
Harue Sasaki, Hiroyuki Masuno, Haru Kawasaki, Ayana Yoshihara, Nobutaka Numoto

J Med Chem· January 2021

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Three-dimensional structure of a high affinity anti-(4-hydroxy-3-nitrophenyl)acetyl antibody possessing a glycine residue at position 95 of the heavy chain.
Akihiro Nishiguchi, Nobutaka Numoto, Nobutoshi Ito, Takachika Azuma, Masayuki Oda

Mol Immunol· October 2019

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Structural and functional properties of Grb2 SH2 dimer in CD28 binding.
Yuhi Hosoe, Nobutaka Numoto, Satomi Inaba, Shuhei Ogawa, Hisayuki Morii

Biophys Physicobiol· February 2019

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