Publications by authors named "Nuruddeen D Lewis"

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A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties.
Kevin Dooley, Russell E McConnell, Ke Xu, Nuruddeen D Lewis, Sonya Haupt

Mol Ther· May 2021

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Exosome Surface Display of IL12 Results in Tumor-Retained Pharmacology with Superior Potency and Limited Systemic Exposure Compared with Recombinant IL12.
Nuruddeen D Lewis, Chang Ling Sia, Katherine Kirwin, Sonya Haupt, Gauri Mahimkar

Mol Cancer Ther· March 2021

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Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection.
Dana M Hardbower, Mohammad Asim, Tracy Murray-Stewart, Robert A Casero, Thomas Verriere, Nuruddeen D Lewis

Amino Acids· October 2016

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A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces experimental autoimmune encephalitis (EAE) in vivo.
Nuruddeen D Lewis, Lori A Patnaude, Josephine Pelletier, Donald J Souza, Susan M Lukas

PLoS One· October 2015

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CCR1 plays a critical role in modulating pain through hematopoietic and non-hematopoietic cells.
Nuruddeen D Lewis, Akalushi Muthukumarana, Steven E Fogal, Laura Corradini, Dimitria E Stefanopoulos

PLoS One· June 2015

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RNA sequencing of microglia and monocyte-derived macrophages from mice with experimental autoimmune encephalomyelitis illustrates a changing phenotype with disease course.
Nuruddeen D Lewis, Jonathan D Hill, Kathryn W Juchem, Dimitria E Stefanopoulos, Louise K Modis

J Neuroimmunol· December 2014

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Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response.
Kshipra Singh, Lori A Coburn, Daniel P Barry, Mohammad Asim, Brooks P Scull, Nuruddeen D Lewis

Am J Physiol Gastrointest Liver Physiol· August 2013

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Circulating monocytes are reduced by sphingosine-1-phosphate receptor modulators independently of S1P3.
Nuruddeen D Lewis, Sokol A Haxhinasto, Shawn M Anderson, Dimitria E Stefanopoulos, Steven E Fogal

J Immunol· April 2013

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Cationic amino acid transporter 2 enhances innate immunity during Helicobacter pylori infection.
Daniel P Barry, Mohammad Asim, Brooks P Scull, M Blanca Piazuelo, Thibaut de Sablet, Nuruddeen D Lewis

PLoS One· August 2012

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Disruption of nitric oxide signaling by Helicobacter pylori results in enhanced inflammation by inhibition of heme oxygenase-1.
Alain P Gobert, Mohammad Asim, M Blanca Piazuelo, Thomas Verriere, Brooks P Scull, Nuruddeen D Lewis

J Immunol· November 2011

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Immune evasion by Helicobacter pylori is mediated by induction of macrophage arginase II.
Nuruddeen D Lewis, Mohammad Asim, Daniel P Barry, Thibaut de Sablet, Kshipra Singh

J Immunol· March 2011

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The apolipoprotein E-mimetic peptide COG112 inhibits NF-kappaB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis.
Kshipra Singh, Rupesh Chaturvedi, Daniel P Barry, Lori A Coburn, Mohammad Asim, Nuruddeen D Lewis

J Biol Chem· February 2011

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Polyamines Impair Immunity to Helicobacter pylori by Inhibiting L-Arginine Uptake Required for Nitric Oxide Production.
Rupesh Chaturvedi, Mohammad Asim, Svea Hoge, Nuruddeen D Lewis, Kshipra Singh

Gastroenterology· November 2010

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Helicobacter pylori induces ERK-dependent formation of a phospho-c-Fos c-Jun activator protein-1 complex that causes apoptosis in macrophages.
Mohammad Asim, Rupesh Chaturvedi, Svea Hoge, Nuruddeen D Lewis, Kshipra Singh

J Biol Chem· June 2010

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Arginase II restricts host defense to Helicobacter pylori by attenuating inducible nitric oxide synthase translation in macrophages.
Nuruddeen D Lewis, Mohammad Asim, Daniel P Barry, Kshipra Singh, Thibaut de Sablet

J Immunol· March 2010

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Matrix metalloproteinase-7 and premalignant host responses in Helicobacter pylori-infected mice.
Seth R Ogden, Jennifer M Noto, Shannon S Allen, Dilan A Patel, Judith Romero-Gallo, Nuruddeen D Lewis

Cancer Res· January 2010

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The apolipoprotein E-mimetic peptide COG112 inhibits the inflammatory response to Citrobacter rodentium in colonic epithelial cells by preventing NF-kappaB activation.
Kshipra Singh, Rupesh Chaturvedi, Mohammad Asim, Daniel P Barry, Nuruddeen D Lewis

J Biol Chem· June 2008

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L-arginine availability regulates inducible nitric oxide synthase-dependent host defense against Helicobacter pylori.
Rupesh Chaturvedi, Mohammad Asim, Nuruddeen D Lewis, Holly M Scott Algood, Timothy L Cover

Infect Immun· September 2007

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