Publications by authors named "Oliver D K Maddocks"

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Developmental mitochondrial complex I activity determines lifespan.
Rhoda Stefanatos, Fiona Robertson, Beatriz Castejon-Vega, Yizhou Yu, Alejandro Huerta Uribe, Kevin Myers, Tetsushi Kataura, Viktor I Korolchuk, Oliver D K Maddocks, L Miguel Martins

EMBO Rep· April 2025

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Multi-node inhibition targeting mTORC1, mTORC2 and PI3Kα potently inhibits the PI3K/AKT/mTOR pathway in endometrial and breast cancer models.
Petros A Tyrakis, Domen Kampjut, Georgina F Steele, H Jonathan G Lindström, Deborah Chirnomas, Oliver D K Maddocks

Br J Cancer· August 2025

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MYC-dependent upregulation of the de novo serine and glycine synthesis pathway is a targetable metabolic vulnerability in group 3 medulloblastoma.
Magretta Adiamah, Bethany Poole, Janet C Lindsey, Sarah Kohe, Alaide Morcavallo, Oliver D K Maddocks

Neuro Oncol· January 2025

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IL-7 promotes integrated glucose and amino acid sensing during homeostatic CD4 T cell proliferation.
Seema Bachoo, Nancy Gudgeon, Rebecca Mann, Victoria Stavrou, Emma L Bishop, Oliver D K Maddocks

Cell Rep· January 2025

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Targeting the autophagy-NAD axis protects against cell death in Niemann-Pick type C1 disease models.
Tetsushi Kataura, Lucia Sedlackova, Congxin Sun, Gamze Kocak, Niall Wilson, Oliver D K Maddocks

Cell Death Dis· May 2024

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Phenotypic profiling of solute carriers characterizes serine transport in cancer.
Vasileios Papalazarou, Alice C Newman, Alejandro Huerta-Uribe, Nathalie M Legrave, Mattia Falcone, Oliver D K Maddocks

Nat Metab· December 2023

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Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target.
Johan Vande Voorde, Rory T Steven, Arafath K Najumudeen, Catriona A Ford, Alex Dexter, Oliver D K Maddocks

Nat Metab· August 2023

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NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency.
Congxin Sun, Elena Seranova, Malkiel A Cohen, Miruna Chipara, Jennie Roberts, Oliver D K Maddocks

Cell Rep· May 2023

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Sensitisation of cancer cells to radiotherapy by serine and glycine starvation.
Mattia Falcone, Alejandro Huerta Uribe, Vasileios Papalazarou, Alice C Newman, Dimitris Athineos, Oliver D K Maddocks

Br J Cancer· November 2022

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Autophagy promotes cell survival by maintaining NAD levels.
Tetsushi Kataura, Lucia Sedlackova, Elsje G Otten, Ruchika Kumari, David Shapira, Oliver D K Maddocks

Dev Cell· November 2022

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Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies.
Charlotte Graham, Rhoda Stefanatos, Angeline E H Yek, Ruth V Spriggs, Samantha H Y Loh, Oliver D K Maddocks

Geroscience· August 2022

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SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance by fueling nucleotide biosynthesis.
Erica Pranzini, Elisa Pardella, Livio Muccillo, Angela Leo, Ilaria Nesi, Oliver D K Maddocks

Cell Rep· August 2022

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Global metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress.
Christian Marx, Jürgen Sonnemann, Oliver D K Maddocks, Lisa Marx-Blümel, Mandy Beyer

Cancer Metab· July 2022

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Mechanistic insights into p53-regulated cytotoxicity of combined entinostat and irinotecan against colorectal cancer cells.
Christian Marx, Jürgen Sonnemann, Mandy Beyer, Oliver D K Maddocks, Sergio Lilla

Mol Oncol· December 2021

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Supply and demand: Cellular nutrient uptake and exchange in cancer.
Vasileios Papalazarou, Oliver D K Maddocks

Mol Cell· September 2021

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Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells.
Alice Clare Newman, Mattia Falcone, Alejandro Huerta Uribe, Tong Zhang, Dimitris Athineos, Oliver David Kenneth Maddocks

Mol Cell· June 2021

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mTORC1 activity is supported by spatial association with focal adhesions.
Yoana Rabanal-Ruiz, Adam Byron, Alexander Wirth, Ralitsa Madsen, Lucia Sedlackova, Oliver D K Maddocks

J Cell Biol· May 2021

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Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy.
Mylène Tajan, Marc Hennequart, Eric C Cheung, Fabio Zani, Andreas K Hock, Oliver D K Maddocks

Nat Commun· January 2021

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SERIneALanine Killer: SPT promiscuity inhibits tumour growth via intra-tumoral deoxysphingolipid production.
Mattia Falcone, Oliver D K Maddocks

Signal Transduct Target Ther· November 2020

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Polyamine pathway activity promotes cysteine essentiality in cancer cells.
Tong Zhang, Christin Bauer, Alice C Newman, Alejandro Huerta Uribe, Dimitris Athineos, Oliver D K Maddocks

Nat Metab· October 2020

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Metabolic cross-feeding in imbalanced diets allows gut microbes to improve reproduction and alter host behaviour.
Sílvia F Henriques, Darshan B Dhakan, Lúcia Serra, Ana Patrícia Francisco, Zita Carvalho-Santos, Oliver D K Maddocks

Nat Commun· August 2020

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The KRAS-BCAA-BCAT2 axis in PDAC development.
Mattia Falcone, Oliver D K Maddocks

Nat Cell Biol· February 2020

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The creatine-phosphagen system is mechanoresponsive in pancreatic adenocarcinoma and fuels invasion and metastasis.
Vassilis Papalazarou, Tong Zhang, Nikki R Paul, Amelie Juin, Marco Cantini, Oliver D K Maddocks

Nat Metab· January 2020

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Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD depletion.
Lucy A Oakey, Rachel S Fletcher, Yasir S Elhassan, David M Cartwright, Craig L Doig, Oliver D K Maddocks

Wellcome Open Res· September 2019

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Use of CN-Serine or CN-Methionine for Studying Methylation Dynamics in Cancer Cell Metabolism and Epigenetics.
Alice C Newman, Christiaan F Labuschagne, Karen H Vousden, Oliver D K Maddocks

Methods Mol Biol· June 2019

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