Developmental mitochondrial complex I activity determines lifespan.

Rhoda Stefanatos, Fiona Robertson, Beatriz Castejon-Vega, Yizhou Yu, Alejandro Huerta Uribe, Kevin Myers, Tetsushi Kataura, Viktor I Korolchuk, Oliver D K Maddocks, L Miguel Martins, Alberto Sanz

April 2025 EMBO Rep

Synopsis of Social media discussions

The discussions highlight specific aspects of the study such as the contrasting effects of mitochondrial dysfunction at different life stages. Comments like 'this challenges what we know about aging' and 'severely reduces survival' illustrate the gravity and novel implications of the research. The tone is both curious and analytical, suggesting that the posts reflect a wide recognition of the research's value in advancing knowledge about lifespan and aging.

A
Agreement
 Strong agreement

The majority of posts express strong support for the publication's key findings, demonstrating a consensus around its importance.

I
Interest
 High level of interest

There is a high level of curiosity reflected in the discussions, indicating that the topic resonates well within the community.

E
Engagement
 Moderate level of engagement

While many posts indicate a general understanding of the findings, some users only skimmed the results, limiting deep engagement.

I
Impact
 High level of impact

Users perceive the research as having a significant impact on the understanding of aging and mitochondrial function, emphasizing its relevance in the field.

Social Mentions

YouTube

2 Videos

Bluesky

2 Posts

Facebook

4 Posts

Twitter

90 Posts

Reddit

2 Posts

Metrics

Video Views

366

Total Likes

288

Extended Reach

909,757

Social Features

100

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Mitochondrial Dysfunction and Its Impact on Lifespan Regulation

Mitochondrial Dysfunction and Its Impact on Lifespan Regulation

The study highlights how reduced mitochondrial complex I activity affects lifespan in fruit flies. It demonstrates that early-life dysfunction severely reduces survival and stress resistance, while disruptions during adulthood lead to resilience and longevity.

The Sanz Science Experience

March 17, 2025

275 views

Mitochondrial Dysfunction and Its Impact on Lifespan

Mitochondrial Dysfunction and Its Impact on Lifespan

This video discusses how reduced activity of mitochondrial complex I affects lifespan, highlighting severe reductions in survival and stress resistance due to early-life dysfunction. It also examines distinct biological responses in long-lived flies, revealing critical insights into longevity.

The Sanz Science Experience

June 8, 2025

92 views

  • Agingdoc
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Abstract Synopsis

  • The study explores how reduced activity of mitochondrial complex I affects lifespan in fruit flies, finding that early-life mitochondrial dysfunction leads to severe reductions in survival and stress resistance later on.
  • In contrast, when mitochondrial function is disrupted during adulthood, the flies remain long-lived and resilient to stress, even with significant reductions in complex I activity.
  • The research identifies distinct biological responses (transcriptomic, proteomic, and metabolomic) in short-lived vs. long-lived populations of flies, indicating that early developmental dysfunction triggers a maladaptive response that hinders survival.