Publications by authors named "Olivier Defert"

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AZP2006 in Progressive Supranuclear Palsy: Outcomes from a Phase 2a Multicenter, Randomized Trial, and Open-Label Extension on Safety, Biomarkers, and Disease Progression.
Jean-Christophe Corvol, Mickael Alexandre Obadia, Caroline Moreau, Louise-Laure Mariani, Jean-Philippe Brandel, Olivier Defert

Mov Disord· December 2025

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AZP2006 (Ezeprogind): a Promising New Drug Candidate in the Battle Against Neurodegenerative Diseases.
Philippe Verwaerde, Olivier Defert

ChemMedChem· May 2025

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Design and synthesis of water-soluble prodrugs of rifabutin for intraveneous administration.
Kevin Antraygues, Mathieu Maingot, Birgit Schellhorn, Vincent Trebosc, Marc Gitzinger, Olivier Defert

Eur J Med Chem· August 2022

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PhAc-ALGP-Dox, a Novel Anticancer Prodrug with Targeted Activation and Improved Therapeutic Index.
Andrea Casazza, Lawrence Van Helleputte, Britt Van Renterghem, Peter Pokreisz, Natalie De Geest, Olivier Defert

Mol Cancer Ther· April 2022

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Treatment of Intestinal Fibrosis in Experimental Inflammatory Bowel Disease by the Pleiotropic Actions of a Local Rho Kinase Inhibitor.
Tom Holvoet, Sarah Devriese, Karolien Castermans, Sandro Boland, Dirk Leysen, Olivier Defert

Gastroenterology· October 2017

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Rho kinase inhibitors: a patent review (2014 - 2016).
Olivier Defert, Sandro Boland

Expert Opin Ther Pat· April 2017

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Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential.
Yangbo Feng, Philip V LoGrasso, Olivier Defert, Rongshi Li

J Med Chem· March 2016

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Kinase profiling in early stage drug discovery: sorting things out.
Olivier Defert, Sandro Boland

Drug Discov Today Technol· November 2015

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Design, synthesis and biological characterization of selective LIMK inhibitors.
Sandro Boland, Arnaud Bourin, Jo Alen, Jacques Geraets, Pieter Schroeders, Olivier Defert

Bioorg Med Chem Lett· September 2015

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Design, synthesis, and biological evaluation of novel, highly active soft ROCK inhibitors.
Sandro Boland, Arnaud Bourin, Jo Alen, Jacques Geraets, Pieter Schroeders, Olivier Defert

J Med Chem· May 2015

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Novel Roflumilast analogs as soft PDE4 inhibitors.
Sandro Boland, Jo Alen, Arnaud Bourin, Karolien Castermans, Nicki Boumans, Olivier Defert

Bioorg Med Chem Lett· September 2014

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AMA0076, a novel, locally acting Rho kinase inhibitor, potently lowers intraocular pressure in New Zealand white rabbits with minimal hyperemia.
Sarah Van de Velde, Tine Van Bergen, Davine Sijnave, Karolien Hollanders, Karolien Castermans, Olivier Defert

Invest Ophthalmol Vis Sci· February 2014

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3-[2-(Aminomethyl)-5-[(pyridin-4-yl)carbamoyl]phenyl] benzoates as soft ROCK inhibitors.
Sandro Boland, Olivier Defert, Jo Alen, Arnaud Bourin, Karolien Castermans

Bioorg Med Chem Lett· December 2013

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