Publications by authors named "Orla Howe"

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Development of ecocentric radiation protection: issues, challenges and approaches.
Carmel Mothersill, Rhea Desai, Frédéric Alonzo, Kentaro Ariyoshi, Andrea Bonisoli-Alquati, Orla Howe

Int J Radiat Biol· December 2025

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Autophagy-dependent cell death and immune responses induced by heteroleptic copper(II), manganese(II), and silver(I) complexes containing dicarboxylate and 1,10-phenanthroline ligands: novel insights from in vitro and in vivo models.
Ella O'Sullivan, Denis O'Shea, Michael Devereux, Kevin Kavanagh, Orla Howe

Biometals· November 2025

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Apoptotic cell death induced by copper (II), manganese (II) and silver (I) complexes containing bridging dicarboxylate and 1,10-phenanthroline ligands: one of the multi-modes of anticancer activity?
Ella O'Sullivan, Denis O'Shea, Michael Devereux, Orla Howe

Biometals· June 2025

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Detection of radiosensitive subpopulations with Raman microspectroscopy.
Aidan D Meade, Adrian Maguire, Jane Bryant, Daniel Cullen, Dinesh Medipally, Orla L Howe

Front Oncol· February 2025

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Structural and solution speciation studies on selected [Cu(NN)(OO)] complexes and an investigation of their biomimetic activity, ROS generation and their cytotoxicity in normoxic, hypoxic and anoxic environments in MCF-7 breast cancer-derived cells.
Hollie Jenkins, Louise MacLean, Siobhán McClean, Gordon Cooke, Michael Devereux, Orla Howe

J Inorg Biochem· December 2023

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Monitoring and modelling the glutamine metabolic pathway: a review and future perspectives.
Zohreh Mirveis, Orla Howe, Paul Cahill, Nitin Patil, Hugh J Byrne

Metabolomics· July 2023

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Antibacterial activity of metal-phenanthroline complexes against multidrug-resistant Irish clinical isolates: a whole genome sequencing approach.
Megan O'Shaughnessy, Jasmine Hurley, Shane C Dillon, Celine Herra, Pauraic McCarron, Orla Howe

J Biol Inorg Chem· March 2023

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Monitoring and modelling the dynamics of the cellular glycolysis pathway: A review and future perspectives.
Nitin Patil, Orla Howe, Paul Cahill, Hugh J Byrne

Mol Metab· December 2022

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Women's contributions to radiobiology in Ireland; from small beginnings….
Orla Howe, Fiona M Lyng, Carmel Mothersill

Int J Radiat Biol· April 2022

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In Vivo Activity of Metal Complexes Containing 1,10-Phenanthroline and 3,6,9-Trioxaundecanedioate Ligands against Infection in Larvae.
Megan O'Shaughnessy, Magdalena Piatek, Pauraic McCarron, Malachy McCann, Michael Devereux, Orla Howe

Biomedicines· January 2022

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A 4-Gene Signature of CDKN1, FDXR, SESN1 and PCNA Radiation Biomarkers for Prediction of Patient Radiosensitivity.
Orla Howe, Lisa White, Daniel Cullen, Grainne O'Brien, Laura Shields

Int J Mol Sci· September 2021

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The Antibacterial Drug Candidate SBC3 is a Potent Inhibitor of Bacterial Thioredoxin Reductase.
Jennie O'Loughlin, Silvia Napolitano, Fahad Alkhathami, Cillian O'Beirne, Daniel Marhöfer, Orla Howe

Chembiochem· March 2021

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Ursolic Acid Inhibits Collective Cell Migration and Promotes JNK-Dependent Lysosomal Associated Cell Death in Glioblastoma Multiforme Cells.
Gillian E Conway, Deimante Zizyte, Julie Rose Mae Mondala, Zhonglei He, Lorna Lynam, Orla Howe

Pharmaceuticals (Basel)· January 2021

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The Antibacterial and Anti-biofilm Activity of Metal Complexes Incorporating 3,6,9-Trioxaundecanedioate and 1,10-Phenanthroline Ligands in Clinical Isolates of from Irish Cystic Fibrosis Patients.
Megan O'Shaughnessy, Pauraic McCarron, Livia Viganor, Malachy McCann, Michael Devereux, Orla Howe

Antibiotics (Basel)· October 2020

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Pt(IV) pro-drugs with an axial HDAC inhibitor demonstrate multimodal mechanisms involving DNA damage and apoptosis independent of cisplatin resistance in A2780/A2780cis cells.
Awatif Rashed Z Almotairy, Diego Montagner, Liam Morrison, Michael Devereux, Orla Howe

J Inorg Biochem· September 2020

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MicroRNA Analysis of ATM-Deficient Cells Indicate PTEN and CCDN1 as Potential Biomarkers of Radiation Response.
Jane Bryant, Lisa White, Natasha Coen, Laura Shields, Brendan McClean, Orla Howe

Radiat Res· June 2020

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Activity of Copper(II), Manganese(II), and Silver(I) 1,10-Phenanthroline Chelates Against Using the Model.
Rafael M Gandra, Pauraic McCarron, Livia Viganor, Mariana Farias Fernandes, Kevin Kavanagh, Orla Howe

Front Microbiol· March 2020

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Cu(ii) phenanthroline-phenazine complexes dysregulate mitochondrial function and stimulate apoptosis.
Garret Rochford, Zara Molphy, Kevin Kavanagh, Malachy McCann, Michael Devereux, Orla Howe

Metallomics· January 2020

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Cold Atmospheric Plasma induces accumulation of lysosomes and caspase-independent cell death in U373MG glioblastoma multiforme cells.
Gillian E Conway, Zhonglei He, Ana Lacramioara Hutanu, George Paul Cribaro, Eline Manaloto, Orla Howe

Sci Rep· September 2019

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Copper(II) complexes of coumarin-derived Schiff base ligands: Pro- or antioxidant activity in MCF-7 cells?
Louise MacLean, Dariusz Karcz, Hollie Jenkins, Siobhán McClean, Michael Devereux, Orla Howe

J Inorg Biochem· August 2019

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Disarming Virulence by the Inhibitory Action of 1,10-Phenanthroline-5,6-Dione-Based Compounds: Elastase B (LasB) as a Chemotherapeutic Target.
Anna Clara M Galdino, Lívia Viganor, Alexandre A de Castro, Elaine F F da Cunha, Thaís P Mello, Orla Howe

Front Microbiol· August 2019

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DNA Damage and Cytokine Production in Non-Target Irradiated Lymphocytes.
Jane Bryant, Laura Shields, Christopher Hynes, Orla Howe, Brendan McCleanc

Radiat Res· June 2019

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Prediction of DNA damage and G2 chromosomal radio-sensitivity ex vivo in peripheral blood mononuclear cells with label-free Raman micro-spectroscopy.
Aidan D Meade, Adrian Maguire, Jane Bryant, Daniel Cullen, Dinesh Medipally, Orla Howe

Int J Radiat Biol· January 2019

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In-vivo evaluation of the response of Galleria mellonella larvae to novel copper(II) phenanthroline-phenazine complexes.
Garret Rochford, Zara Molphy, Niall Browne, Carla Surlis, Michael Devereux, Orla Howe

J Inorg Biochem· September 2018

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Tetrameric and polymeric silver complexes of the omeprazole scaffold; synthesis, structure, in vitro and in vivo antimicrobial activities and DNA interaction.
Vibe Jakobsen, Livia Viganor, Alfonso Blanco-Fernández, Orla Howe, Michael Devereux

J Inorg Biochem· September 2018

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