Publications by authors named "Owain Howell"

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ProCyon: A multimodal foundation model for protein phenotypes.
Owen Queen, Yepeng Huang, Robert Calef, Valentina Giunchiglia, Tianlong Chen, Owain Howell

bioRxiv· November 2025

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Sterol imbalances and cholesterol-24-hydroxylase dysregulation is linked to the underlying progression of multiple sclerosis.
Lauren Griffiths, Kristen Hawkins, Eylan Yutuc, Roberto Angelini, Racheal Fosuah, Owain W Howell

Brain Pathol· September 2025

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Mapping Molecular Pathways of Multiple Sclerosis: A Gene Prioritization and Network Analysis of White Matter Pathology Transcriptomics.
Gianmarco Abbadessa, Ai Nagano, Simon Hametner, Owain Howell, David Owen

Ann Neurol· July 2025

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Intrathecal Inflammatory Profile and Gray Matter Damage Predict Progression Independent of Relapse Activity in Early Multiple Sclerosis.
Damiano Marastoni, Elisa Colato, Matteo Foschi, Agnese Tamanti, Stefano Ziccardi, Owain Howell

Neurol Neuroimmunol Neuroinflamm· July 2025

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Metabolic profiling in serum, cerebrospinal fluid, and brain of patients with cerebrotendinous xanthomatosis.
Philip Höflinger, Stefan Hauser, Eylan Yutuc, Holger Hengel, Lauren Griffiths, Owain W Howell

J Lipid Res· July 2024

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Determinants and Biomarkers of Progression Independent of Relapses in Multiple Sclerosis.
Massimiliano Calabrese, Paolo Preziosa, Antonio Scalfari, Elisa Colato, Damiano Marastoni, Owain W Howell

Ann Neurol· July 2024

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Digital Pathology Identifies Associations between Tissue Inflammatory Biomarkers and Multiple Sclerosis Outcomes.
Benjamin Cooze, James Neal, Alka Vineed, J C Oliveira, Lauren Griffiths, Owain Howell

Cells· June 2024

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High Levels of Perivascular Inflammation and Active Demyelinating Lesions at Time of Death Associated with Rapidly Progressive Multiple Sclerosis Disease Course: A Retrospective Postmortem Cohort Study.
Richard Nicholas, Roberta Magliozzi, Damiano Marastoni, Owain Howell, Federico Roncaroli

Ann Neurol· April 2024

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Comparing the Pathology, Clinical, and Demographic Characteristics of Younger and Older-Onset Multiple Sclerosis.
Sarah Knowles, Rod Middleton, Benjamin Cooze, Ildiko Farkas, Yeung Yeung Leung, Owain W Howell

Ann Neurol· March 2024

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Inhibition of 7α,26-dihydroxycholesterol biosynthesis promotes midbrain dopaminergic neuron development.
James Hennegan, Aled H Bryant, Lauren Griffiths, Matthieu Trigano, Oliver J M Bartley, Owain W Howell

iScience· January 2024

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Meningeal inflammation as a driver of cortical grey matter pathology and clinical progression in multiple sclerosis.
Roberta Magliozzi, Owain W Howell, Massimiliano Calabrese, Richard Reynolds

Nat Rev Neurol· August 2023

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Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases.
Erik Nutma, Nurun Fancy, Maria Weinert, Stergios Tsartsalis, Manuel C Marzin, Owain W Howell

Nat Commun· August 2023

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Complement activation and increased anaphylatoxin receptor expression are associated with cortical grey matter lesions and the compartmentalised inflammatory response of multiple sclerosis.
Rhian Evans, Lewis M Watkins, Kristen Hawkins, Gabriella Santiago, Constantinos Demetriou, Owain W Howell

Front Cell Neurosci· March 2023

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Analysis of target mRNAs in the fixed-frozen human brain using a modified BaseScope-ISH Assay protocol.
M Carla Carisì, Owain W Howell, Alwena H Morgan, Jeffrey S Davies

STAR Protoc· December 2022

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"Ependymal-in" Gradient of Thalamic Damage in Progressive Multiple Sclerosis.
Roberta Magliozzi, Giulia Fadda, Robert A Brown, Amit Bar-Or, Owain W Howell

Ann Neurol· October 2022

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A Review of Compartmentalised Inflammation and Tertiary Lymphoid Structures in the Pathophysiology of Multiple Sclerosis.
Rachael Kee, Michelle Naughton, Gavin V McDonnell, Owain W Howell, Denise C Fitzgerald

Biomedicines· October 2022

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The association between neurodegeneration and local complement activation in the thalamus to progressive multiple sclerosis outcome.
Benjamin J Cooze, Matthew Dickerson, Rukshikah Loganathan, Lewis M Watkins, Ethan Grounds, Owain W Howell

Brain Pathol· September 2022

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Visualizing Cholesterol in the Brain by On-Tissue Derivatization and Quantitative Mass Spectrometry Imaging.
Roberto Angelini, Eylan Yutuc, Mark F Wyatt, Jillian Newton, Fowzi A Yusuf, Owain W Howell

Anal Chem· March 2021

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Neuroinflammation in the normal-appearing white matter (NAWM) of the multiple sclerosis brain causes abnormalities at the nodes of Ranvier.
Patricia Gallego-Delgado, Rachel James, Eleanor Browne, Joanna Meng, Swetha Umashankar, Owain W Howell

PLoS Biol· December 2020

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CCN3 is dynamically regulated by treatment and disease state in multiple sclerosis.
Michelle Naughton, Jill Moffat, George Eleftheriadis, Nira de la Vega Gallardo, Andrew Young, Owain Howell

J Neuroinflammation· November 2020

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Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson's Dementia in Humans.
Amanda K E Hornsby, Luke Buntwal, Maria Carla Carisi, Vanessa V Santos, Fionnuala Johnston, Owain Howell

Cell Rep Med· October 2020

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B cell rich meningeal inflammation associates with increased spinal cord pathology in multiple sclerosis.
Camilla Reali, Roberta Magliozzi, Federico Roncaroli, Richard Nicholas, Owain W Howell

Brain Pathol· July 2020

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Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism.
Eylan Yutuc, Roberto Angelini, Mark Baumert, Natalia Mast, Irina Pikuleva, Owain W Howell

Proc Natl Acad Sci U S A· March 2020

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Meningeal inflammation changes the balance of TNF signalling in cortical grey matter in multiple sclerosis.
Roberta Magliozzi, Owain William Howell, Pascal Durrenberger, Eleonora Aricò, Rachel James

J Neuroinflammation· December 2019

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Using biomarkers to predict clinical outcomes in multiple sclerosis.
Daniel Castle, Ray Wynford-Thomas, Sam Loveless, Emily Bentley, Owain W Howell

Pract Neurol· August 2019

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