Publications by authors named "Pablo Machado"

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In Vitro and In Silico Evaluation of Isatin-Derived Spirooxindoles as Antituberculosis Drug Candidates.
Fernanda Rodrigues de Lima, Jéssika de Oliveira Viana, Aleff Cruz de Castro, Rodrigo Cristiano, Marcia Alberton Perelló, Pablo Machado

Chem Biol Drug Des· July 2025

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Scaffold Hopping Strategy toward New 4‑Aminoquinazolines Active Against Extracellular and Intracellular.
Guilherme Arraché Gonçalves, Alexia de Matos Czeczot, Marcia Alberton Perelló, Eric Greve, Renee Allen, Pablo Machado

ACS Med Chem Lett· July 2025

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Preclinical Evaluation of Selene-Ethylenelacticamides in Tuberculosis: Effects Against Active, Dormant, and Resistant and In Vitro Toxicity Investigation.
Natália Ferreira de Sousa, Maria Eugênia G de Freitas, Maria Gabriella S Sidrônio, Helivaldo Diógenes Souza, Alexia Czeczot, Pablo Machado

Microorganisms· February 2025

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Crystal structure of dihydroneopterin aldolase from associated with 8-mercaptoguanine, and development of novel S8-functionalized analogues as inhibitors: Synthesis, enzyme inhibition, toxicity and antitubercular activity.
Alexia de Matos Czeczot, Mauro Neves Muniz, Marcia Alberton Perelló, Éverton Edésio Dinis Silva, Luís Fernando Saraiva Macedo Timmers, Pablo Machado

J Enzyme Inhib Med Chem· December 2024

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Unveiling the Antimycobacterial Potential of Novel 4-Alkoxyquinolines: Insights into Selectivity, Mechanism of Action, and Exposure.
Fernanda Fries da Silva, Josiane Delgado Paz, Raoní Scheibler Rambo, Guilherme Arraché Gonçalves, Mauro Neves Muniz, Pablo Machado

J Med Chem· December 2024

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Large-scale proteogenomics characterization of microproteins in Mycobacterium tuberculosis.
Eduardo V de Souza, Pedro F Dalberto, Adriana C Miranda, Alan Saghatelian, Antonio M Pinto, Pablo Machado

Sci Rep· December 2024

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Identification of antimycobacterial 8-hydroxyquinoline derivatives as in vitro enzymatic inhibitors of Mycobacterium tuberculosis enoyl-acyl carrier protein reductase.
Angélica Rocha Joaquim, Marcela Silva Lopes, Isadora Serraglio Fortes, Caroline de Bem Gentz, Alexia de Matos Czeczot, Pablo Machado

Bioorg Chem· October 2024

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Losartan and enalapril maleate differently influence SARS-CoV-2-infected vero cells.
Julia H Majolo, João I B Gonçalves, Renata P Souza, Laura C González, Nathalia Sperotto, Pablo Machado

Sci Rep· October 2024

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Rp3: Ribosome profiling-assisted proteogenomics improves coverage and confidence during microprotein discovery.
Eduardo Vieira de Souza, Angie L Bookout, Christopher A Barnes, Brendan Miller, Pablo Machado

Nat Commun· August 2024

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5-Fluoroindole Reduces the Bacterial Burden in a Murine Model of Infection.
Christiano E Neves, Josiane D Paz, Bruno L Abbadi, Raoní S Rambo, Alexia M Czeczot, Pablo Machado

ACS Omega· July 2024

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Exploring Scaffold Hopping for Novel 2-(Quinolin-4-yloxy)acetamides with Enhanced Antimycobacterial Activity.
Ana Flávia Borsoi, Alessandro Silva Ramos, Nathalia Sperotto, Bruno Lopes Abbadi, Fernanda Souza Macchi Hopf, Pablo Machado

ACS Med Chem Lett· April 2024

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Deucravacitinib for Moderate-to-Severe Psoriasis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Otavio A S Toth, Patrick F Meldola, Pablo G Machado, Gabriel F C Chiarelli, Erick Schnorrenberger

J Drugs Dermatol· February 2024

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Sublobar resection versus lobectomy for stage IA non-small-cell lung cancer: A systematic review and meta-analysis of randomized controlled trials.
Patrick F Meldola, Otávio A S Toth, Erick Schnorrenberger, Pablo G Machado, Gabriel F C Chiarelli

Surg Oncol· December 2023

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Fatigue resistance of monolithic and multilayer zirconia crowns using veneer layering or CAD-on technique.
Alvim Gustavo Fasolin Tomm, Pablo Soares Machado, Lucas Saldanha da Rosa, Gabriel Kalil Rocha Pereira, Aloisio Oro Spazzin

Braz Dent J· December 2023

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The Integration of Proteogenomics and Ribosome Profiling Circumvents Key Limitations to Increase the Coverage and Confidence of Novel Microproteins.
Eduardo V de Souza, Angie L Bookout, Christopher A Barnes, Brendan Miller, Pablo Machado

bioRxiv· October 2023

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Fatigue performance analysis of strength-graded zirconia polycrystals for monolithic three-unit implant-supported prostheses.
Gabriel Marini, Lucas Saldanha da Rosa, Pablo Soares Machado, Francisbênia Alves Silvestre, Luiz Felipe Valandro

J Mech Behav Biomed Mater· April 2023

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SARS-CoV-2 immune complex triggers human monocyte necroptosis.
Leonardo Duarte Santos, Krist Helen Antunes, Gisele Cassão, João Ismael Gonçalves, Bruno Lopes Abbadi, Pablo Machado

Int Immunopharmacol· April 2023

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Identification of potential inhibitors of Mycobacterium tuberculosis shikimate kinase: molecular docking, in silico toxicity and in vitro experiments.
Talita Freitas de Freitas, Candida Deves Roth, Bruno Lopes Abbadi, Fernanda Souza Macchi Hopf, Marcia Alberton Perelló, Pablo Machado

J Comput Aided Mol Des· March 2023

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Novel 4-aminoquinolines: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase, antitubercular activity, SAR, and preclinical evaluation.
Josiane Delgado Paz, Nathalia Denise de Moura Sperotto, Alessandro Silva Ramos, Kenia Pissinate, Valnês da Silva Rodrigues Junior, Pablo Machado

Eur J Med Chem· January 2023

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Influence of connector cross-sectional geometry on the load-bearing capacity under fatigue of implant-supported zirconia fixed partial prosthesis.
Renan Luiz Luft, Lucas Saldanha da Rosa, Pablo Soares Machado, Luiz Felipe Valandro, Rafael Sarkis-Onofre

J Prosthet Dent· December 2022

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Viral isolation allows characterization of early samples of SARS-CoV-2 lineage B1.1.33 with unique mutations (S: H655Y and T63N) circulating in Southern Brazil in 2020.
Juliana Schons Gularte, Mariana Soares da Silva, Micheli Filippi, Meriane Demoliner, Karoline Schallenberger, Pablo Machado

Braz J Microbiol· September 2022

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Evaluation of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase (DAHPS) as a Vulnerable Target in Mycobacterium tuberculosis.
Luiza Galina, Fernanda S M Hopf, Bruno Lopes Abbadi, Nathalia D de Moura Sperotto, Alexia M Czeczot, Pablo Machado

Microbiol Spectr· August 2022

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Antitubercular Activity of Novel 2-(Quinoline-4-yloxy)acetamides with Improved Drug-Like Properties.
Ana Flávia Borsoi, Laura Manzoli Alice, Nathalia Sperotto, Alessandro Silva Ramos, Bruno Lopes Abbadi, Pablo Machado

ACS Med Chem Lett· August 2022

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Bacterial Enoyl-Reductases: The Ever-Growing List of Fabs, Their Mechanisms and Inhibition.
Fernanda S M Hopf, Candida D Roth, Eduardo V de Souza, Luiza Galina, Alexia M Czeczot, Pablo Machado

Front Microbiol· June 2022

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Synthesis and Antimycobacterial Evaluation of -(4-(Benzyloxy)benzyl)-4-aminoquinolines.
Estevão Silveira Grams, Alessandro Silva Ramos, Mauro Neves Muniz, Raoní S Rambo, Marcia Alberton Perelló, Pablo Machado

Molecules· April 2022

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