Publications by authors named "Pankaj B Desai"

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Preclinical Evaluation of the Efficacy of a Cyclin-dependent Kinase Inhibitor Ribociclib in Combination with Letrozole Against Patient-Derived Glioblastoma Cells.
Sidharth N Gadgil, Aniruddha S Karve, Gary A Gudelsky, Bhavesh B Gabani, Mario Medvedovic, Pankaj B Desai

Mol Cancer Ther· September 2025

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Vancomycin dosing in neonates: enhancing outcomes using population pharmacokinetics and simulation.
Sílvia M Illamola, Jiraganya Jj Bhongsatiern, Angela K Birnbaum, Shaun S Kumar, Joshua D Courter, Pankaj B Desai

Front Antibiot· May 2025

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GABA(A) Receptor Activation Drives GABARAP-Nix Mediated Autophagy to Radiation-Sensitize Primary and Brain-Metastatic Lung Adenocarcinoma Tumors.
Debanjan Bhattacharya, Riccardo Barrile, Donatien Kamdem Toukam, Vaibhavkumar S Gawali, Laura Kallay, Pankaj B Desai

Cancers (Basel)· September 2024

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A Phase 0/I Pharmacokinetic and Pharmacodynamics and Safety and Tolerability Study of Letrozole in Combination with Standard Therapy in Recurrent High-Grade Gliomas.
Pankaj B Desai, Aniruddha S Karve, Misam Zawit, Priyanka Arora, Nimita Dave

Clin Cancer Res· May 2024

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A Review of Approaches to Potentiate the Activity of Temozolomide against Glioblastoma to Overcome Resistance.
Aniruddha S Karve, Janki M Desai, Sidharth N Gadgil, Nimita Dave, Trisha M Wise-Draper, Pankaj B Desai

Int J Mol Sci· March 2024

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GABA(A) receptor activation drives GABARAP-Nix mediated autophagy to radiation-sensitize primary and brain-metastatic lung adenocarcinoma tumors.
Debanjan Bhattacharya, Riccardo Barille, Donatien Kamdem Toukam, Vaibhavkumar S Gawali, Laura Kallay, Pankaj B Desai

bioRxiv· December 2023

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Brain pharmacokinetics and metabolism of the AMP-activated protein kinase selective inhibitor SBI-0206965, an investigational agent for the treatment of glioblastoma.
Janki M Desai, Aniruddha S Karve, Gary A Gudelsky, Mruniya V Gawali, William Seibel, Pankaj B Desai

Invest New Drugs· October 2022

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Potentiation of temozolomide activity against glioblastoma cells by aromatase inhibitor letrozole.
Aniruddha S Karve, Janki M Desai, Nimita Dave, Trisha M Wise-Draper, Gary A Gudelsky, Pankaj B Desai

Cancer Chemother Pharmacol· October 2022

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Gender-based differences in brain and plasma pharmacokinetics of letrozole in sprague-dawley rats: Application of physiologically-based pharmacokinetic modeling to gain quantitative insights.
Priyanka Arora, Gary Gudelsky, Pankaj B Desai

PLoS One· September 2021

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A First-In-Class, Humanized Antibody Targeting Alternatively Spliced Tissue Factor: Preclinical Evaluation in an Orthotopic Model of Pancreatic Ductal Adenocarcinoma.
Clayton S Lewis, Aniruddha Karve, Kateryna Matiash, Timothy Stone, Jingxing Li, Pankaj B Desai

Front Oncol· July 2021

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Biotherapy of Brain Tumors with Phosphatidylserine-Targeted Radioiodinated SapC-DOPS Nanovesicles.
Harold W Davis, Subrahmanya D Vallabhapurapu, Zhengtao Chu, Michael A Wyder, Kenneth D Greis, Pankaj B Desai

Cells· August 2020

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Phase 1 dose-finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer.
Shuchi Gulati, Janki Desai, Sarah M Palackdharry, John C Morris, Zheng Zhu, Pankaj B Desai

Cancer· January 2020

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Plasma and brain pharmacokinetics of letrozole and drug interaction studies with temozolomide in NOD-scid gamma mice and sprague dawley rats.
Priyanka Arora, Courtney Huff Adams, Gary Gudelsky, Biplab DasGupta, Pankaj B Desai

Cancer Chemother Pharmacol· January 2019

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Preclinical pharmacokinetic evaluation to facilitate repurposing of tyrosine kinase inhibitors nilotinib and imatinib as antiviral agents.
Hari Krishna Ananthula, Scott Parker, Erin Touchette, R Mark Buller, Gopi Patel, Pankaj B Desai

BMC Pharmacol Toxicol· December 2018

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Acylhydrazones as Antifungal Agents Targeting the Synthesis of Fungal Sphingolipids.
Cristina Lazzarini, Krupanandan Haranahalli, Robert Rieger, Hari Krishna Ananthula, Pankaj B Desai

Antimicrob Agents Chemother· May 2018

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Erratum for Mor et al., "Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids".
Visesato Mor, Antonella Rella, Amir M Farnoud, Ashutosh Singh, Mansa Munshi, Pankaj B Desai

mBio· March 2018

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Renal Function Descriptors in Neonates: Which Creatinine-Based Formula Best Describes Vancomycin Clearance?
Jiraganya Bhongsatiern, Chris Stockmann, Tian Yu, Jonathan E Constance, Ganesh Moorthy, Pankaj B Desai

J Clin Pharmacol· May 2016

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Evaluation of Vancomycin Use in Late-Onset Neonatal Sepsis Using the Area Under the Concentration-Time Curve to the Minimum Inhibitory Concentration ≥400 Target.
Jiraganya Bhongsatiern, Chris Stockmann, Jessica K Roberts, Tian Yu, Kent E Korgenski, Pankaj B Desai

Ther Drug Monit· December 2015

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Safety, tolerability and pharmacokinetics of 2-pyridylacetic acid, a major metabolite of betahistine, in a phase 1 dose escalation study in subjects with ADHD.
Ganesh Moorthy, Floyd Sallee, Prasad Gabbita, Frank Zemlan, Larry Sallans, Pankaj B Desai

Biopharm Drug Dispos· October 2015

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Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids.
Visesato Mor, Antonella Rella, Amir M Farnoud, Ashutosh Singh, Mansa Munshi, Pankaj B Desai

mBio· June 2015

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Preclinical pharmacological evaluation of letrozole as a novel treatment for gliomas.
Nimita Dave, Lionel M L Chow, Gary A Gudelsky, Kathleen LaSance, Xiaoyang Qi, Pankaj B Desai

Mol Cancer Ther· April 2015

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Manipulation of olfactory tight junctions using papaverine to enhance intranasal delivery of gemcitabine to the brain.
Mansi Krishan, Gary A Gudelsky, Pankaj B Desai, Mary Beth Genter

Drug Deliv· February 2014

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The pharmacokinetics of letrozole in brain and brain tumor in rats with orthotopically implanted C6 glioma, assessed using intracerebral microdialysis.
Nimita Dave, Gary A Gudelsky, Pankaj B Desai

Cancer Chemother Pharmacol· August 2013

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The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects.
Jenny Tong, Nimita Dave, Ganesh M Mugundu, Harold W Davis, Bruce D Gaylinn, Pankaj B Desai

Eur J Endocrinol· June 2013

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Quantification of human hepatocyte cytochrome P450 enzymes and transporters induced by HIV protease inhibitors using newly validated LC-MS/MS cocktail assays and RT-PCR.
Li Liu, Ganesh M Mugundu, Brian J Kirby, Divya Samineni, Pankaj B Desai

Biopharm Drug Dispos· May 2012

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