Publications by authors named "Paris Ward"

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Discovery and SAR Study of Boronic Acid-Based Selective PDE3B Inhibitors from a Novel DNA-Encoded Library.
Ann M Rowley, Gang Yao, Logan Andrews, Aaron Bedermann, Ross Biddulph, Paris Ward

J Med Chem· February 2024

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Exploration of the P1 residue in 3CL protease inhibitors leading to the discovery of a 2-tetrahydrofuran P1 replacement.
Linda S Barton, James F Callahan, Juan Cantizani, Nestor O Concha, Ignacio Cotillo Torrejon, Paris Ward

Bioorg Med Chem· February 2024

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Novel Bent Conformation of CD4 Induced by HIV-1 Inhibitor Indirectly Prevents Productive Viral Attachment.
David Wensel, Shawn Williams, David P Dixon, Paris Ward, Patti McCormick

J Mol Biol· January 2022

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The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure.
Rodolfo Cadilla, David N Deaton, Young Do, Patricia A Elkins, Daniela Ennulat, Paris Ward

Bioorg Med Chem· December 2020

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Discovery of piperazic acid peptide deformylase inhibitors with in vivo activity for respiratory tract and skin infections.
Jared T Spletstoser, Jason Dreabit, Andrew N Knox, Andrew Benowitz, Nino Campobasso, Paris Ward

Bioorg Med Chem Lett· August 2019

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Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
Philip A Harris, Nicolas Faucher, Nicolas George, Patrick M Eidam, Bryan W King, Paris Ward

J Med Chem· May 2019

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The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors.
David N Deaton, Young Do, Jason Holt, Michael R Jeune, H Fritz Kramer, Paris Ward

Bioorg Med Chem· April 2019

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Identification and Optimization of Novel Small c-Abl Kinase Activators Using Fragment and HTS Methodologies.
Graham L Simpson, Sophie M Bertrand, Jennifer A Borthwick, Nino Campobasso, Julien Chabanet, Paris Ward

J Med Chem· February 2019

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Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.
Philip A Harris, Scott B Berger, Jae U Jeong, Rakesh Nagilla, Deepak Bandyopadhyay, Paris Ward

J Med Chem· February 2017

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DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.
Philip A Harris, Bryan W King, Deepak Bandyopadhyay, Scott B Berger, Nino Campobasso, Paris Ward

J Med Chem· March 2016

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Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO.
Anne Cleasby, Jeff Yon, Philip J Day, Caroline Richardson, Ian J Tickle, Paris Ward

PLoS One· August 2015

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Structure-guided optimization of small molecule c-Abl activators.
Xuan Hong, Ping Cao, Yoshiaki Washio, Graham Simpson, Nino Campobasso, Paris Ward

J Comput Aided Mol Des· February 2014

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Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis.
Philip A Harris, Deepak Bandyopadhyay, Scott B Berger, Nino Campobasso, Carol A Capriotti, Paris Ward

ACS Med Chem Lett· December 2013

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Acylprolinamides: a new class of peptide deformylase inhibitors with in vivo antibacterial activity.
Jeffrey M Axten, Jesús R Medina, Charles W Blackledge, Céline Duquenne, Seth W Grant, Paris Ward

Bioorg Med Chem Lett· June 2012

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Understanding the origins of time-dependent inhibition by polypeptide deformylase inhibitors.
Rachel Totoritis, Chaya Duraiswami, Amy N Taylor, John J Kerrigan, Nino Campobasso, Paris Ward

Biochemistry· August 2011

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Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors.
Jesús R Medina, Christopher J Becker, Charles W Blackledge, Celine Duquenne, Yanhong Feng, Paris Ward

J Med Chem· March 2011

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Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site.
Jingsong Yang, Nino Campobasso, Mangatt P Biju, Kelly Fisher, Xiao-Qing Pan, Paris Ward

Chem Biol· February 2011

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Aminoindazole PDK1 Inhibitors: A Case Study in Fragment-Based Drug Discovery.
Jesús R Medina, Charles W Blackledge, Dirk A Heerding, Nino Campobasso, Paris Ward

ACS Med Chem Lett· November 2010

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Baculovirus production of fully-active phosphoinositide 3-kinase alpha as a p85alpha-p110alpha fusion for X-ray crystallographic analysis with ATP competitive enzyme inhibitors.
Robert H Sinnamon, Patrick McDevitt, Beth L Pietrak, Vaughan R Leydon, Yu Xue, Paris Ward

Protein Expr Purif· October 2010

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Conservation of Sox4 gene structure and expression during chicken embryogenesis.
Kathryn L Maschhoff, Paul Q Anziano, Paris Ward, H Scott Baldwin

Gene· November 2003

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