Publications by authors named "Parthasarathi Ajitkumar"

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Percoll discontinuous density gradient centrifugation method for the fractionation of the subpopulations of and from cultures.
Srinivasan Vijay, Rashmi Ravindran Nair, Deepti Sharan, Kishor Jakkala, Parthasarathi Ajitkumar

MethodsX· December 2023

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Growth and division mechanisms by which genetic resisters emerge from the rifampicin-surviving population of differentially antibiotic-susceptible mycobacterial subpopulations.
Kishor Jakkala, Avraneel Paul, Rashmi Ravindran Nair, Sharmada Swaminath, Atul Pradhan, Parthasarathi Ajitkumar

Int J Mycobacteriol· October 2022

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Complete identity and expression of StfZ, the -antisense RNA to the mRNA of the cell division gene , in .
Deepak Anand, Kishor Jakkala, Rashmi Ravindran Nair, Deepti Sharan, Atul Pradhan, Parthasarathi Ajitkumar

Front Microbiol· October 2022

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strains genetically resistant to moxifloxacin emerge from the moxifloxacin-surviving population containing high levels of superoxide, HO, hydroxyl radical, and Fe (II).
Avraneel Paul, Rashmi Ravindran Nair, Kishor Jakkala, Parthasarathi Ajitkumar

Int J Mycobacteriol· July 2022

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The HO inherently released by the mycobacterial minor subpopulation enhances the survival of the major kin subpopulation against rifampicin.
Rashmi Ravindran Nair, Deepti Sharan, Vijay Srinivasan, Nagaraja Mukkayyan, Kishor Jakkala, Parthasarathi Ajitkumar

Curr Res Microb Sci· June 2022

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Elevated Levels of Three Reactive Oxygen Species and Fe(II) in the Antibiotic-Surviving Population of Mycobacteria Facilitate Emergence of Genetic Resisters to Antibiotics.
Avraneel Paul, Rashmi Ravindran Nair, Kishor Jakkala, Atul Pradhan, Parthasarathi Ajitkumar

Antimicrob Agents Chemother· May 2022

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Deletion of rifampicin-inactivating mono-ADP-ribosyl transferase gene of globally altered gene expression profile that favoured increase in ROS levels and thereby antibiotic resister generation.
Sharmada Swaminath, Atul Pradhan, Rashmi Ravindran Nair, Parthasarathi Ajitkumar

Curr Res Microb Sci· May 2022

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Genetic resisters to antibiotics in Escherichia coli arise from the antibiotic-surviving population containing three reactive oxygen species.
Avraneel Paul, Rashmi Ravindran Nair, Parthasarathi Ajitkumar

FEMS Microbiol Lett· January 2022

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A method for the enrichment, isolation and validation of Mycobacterium smegmatis population surviving in the presence of bactericidal concentrations of rifampicin and moxifloxacin.
Atul Pradhan, Sharmada Swaminath, Kishor Jakkala, Parthasarathi Ajitkumar

FEMS Microbiol Lett· July 2021

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Mycobacterial Populations Partly Change the Proportions of the Cells Undergoing Asymmetric/Symmetric Divisions in Response to Glycerol Levels in Growth Medium.
Atul Pradhan, Nagaraja Mukkayyan, Kishor Jakkala, Parthasarathi Ajitkumar

Cells· May 2021

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Cells Surviving in the Continued Presence of Bactericidal Concentrations of Rifampicin Develop Negatively Charged Thickened Capsular Outer Layer That Restricts Permeability to the Antibiotic.
Jees Sebastian, Rashmi Ravindran Nair, Sharmada Swaminath, Parthasarathi Ajitkumar

Front Microbiol· December 2020

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Unique Mode of Cell Division by the Mycobacterial Genetic Resister Clones Emerging from the Antibiotic-Surviving Population.
Kishor Jakkala, Avraneel Paul, Atul Pradhan, Rashmi Ravindran Nair, Deepti Sharan, Parthasarathi Ajitkumar

mSphere· November 2020

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moxifloxacin persister cells produce high levels of hydroxyl radical, generating genetic resisters selectable not only with moxifloxacin, but also with ethambutol and isoniazid.
Sharmada Swaminath, Avraneel Paul, Atul Pradhan, Jees Sebastian, Rashmi Ravindran Nair, Parthasarathi Ajitkumar

Microbiology (Reading)· February 2020

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MtFtsX a predicted membrane domain of ABC transporter complex MtFtsEX of interacts with the cell division protein MtFtsZ.
Mushtaq Ahmad Mir, Ramanujam Srinivasan, Parthasarathi Ajitkumar

Int J Mycobacteriol· January 2020

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Correction: The multifunctional PE_PGRS11 protein from plays a role in regulating resistance to oxidative stress.
Rashmi Chaturvedi, Kushagra Bansal, Yeddula Narayana, Nisha Kapoor, Namineni Sukumar, Parthasarathi Ajitkumar

J Biol Chem· December 2019

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Hypoxic Non-replicating Persistent Develops Thickened Outer Layer That Helps in Restricting Rifampicin Entry.
Kishor Jakkala, Parthasarathi Ajitkumar

Front Microbiol· October 2019

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A Minor Subpopulation of Mycobacteria Inherently Produces High Levels of Reactive Oxygen Species That Generate Antibiotic Resisters at High Frequency From Itself and Enhance Resister Generation From Its Major Kin Subpopulation.
Rashmi Ravindran Nair, Deepti Sharan, Parthasarathi Ajitkumar

Front Microbiol· August 2019

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Heterogeneity of ROS levels in antibiotic-exposed mycobacterial subpopulations confers differential susceptibility.
Rashmi Ravindran Nair, Deepti Sharan, Jees Sebastian, Sharmada Swaminath, Parthasarathi Ajitkumar

Microbiology (Reading)· June 2019

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Redox-dependent condensation of the mycobacterial nucleoid by WhiB4.
Manbeena Chawla, Saurabh Mishra, Kushi Anand, Pankti Parikh, Mansi Mehta, Parthasarathi AjitKumar

Redox Biol· October 2018

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A Symmetric Molecule Produced by Mycobacteria Generates Cell-Length Asymmetry during Cell-Division and Thereby Cell-Length Heterogeneity.
Nagaraja Mukkayyan, Deepti Sharan, Parthasarathi Ajitkumar

ACS Chem Biol· June 2018

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Mycobacterial Cultures Contain Cell Size and Density Specific Sub-populations of Cells with Significant Differential Susceptibility to Antibiotics, Oxidative and Nitrite Stress.
Srinivasan Vijay, Rashmi Ravindran Nair, Deepti Sharan, Kishor Jakkala, Nagaraja Mukkayyan, Parthasarathi Ajitkumar

Front Microbiol· March 2017

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De Novo Emergence of Genetically Resistant Mutants of Mycobacterium tuberculosis from the Persistence Phase Cells Formed against Antituberculosis Drugs In Vitro.
Jees Sebastian, Sharmada Swaminath, Rashmi Ravindran Nair, Kishor Jakkala, Atul Pradhan, Parthasarathi Ajitkumar

Antimicrob Agents Chemother· February 2017

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NDK Interacts with FtsZ and Converts GDP to GTP to Trigger FtsZ Polymerisation--A Novel Role for NDK.
Saurabh Mishra, Kishor Jakkala, Ramanujam Srinivasan, Muthu Arumugam, Raghavendra Ranjeri, Parthasarathi Ajitkumar

PLoS One· July 2016

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Mycobacterium tuberculosis cell division protein, FtsE, is an ATPase in dimeric form.
Mushtaq Ahmad Mir, Muthu Arumugam, Sukanta Mondal, Haryadi S Rajeswari, Suryanarayanarao Ramakumar, Parthasarathi Ajitkumar

Protein J· February 2015

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Highly Deviated Asymmetric Division in Very Low Proportion of Mycobacterial Mid-log Phase Cells.
Srinivasan Vijay, Nagaraja Mukkayyan, Parthasarathi Ajitkumar

Open Microbiol J· June 2014

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