Publications by authors named "Pascal Bonaventure"

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Pharmacological characterisation of JNJ-78911118, a novel, centrally-penetrant, selective GluN2A antagonist.
Brian Lord, Sirak Simavorian, Ian Fraser, Natalie Welty, Ryan Wyatt, Pascal Bonaventure

Br J Pharmacol· September 2025

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Design, Synthesis, and Characterization of GluN2A Negative Allosteric Modulators Suitable for In Vivo Exploration.
François P Bischoff, Sven Van Brandt, Marcel Viellevoye, Michel De Cleyn, Michel Surkyn, Pascal Bonaventure

J Med Chem· February 2025

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Characterization of tritiated JNJ-GluN2B-5 (3-[H] 1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyridin-1-yl)ethanone), a high affinity GluN2B radioligand with selectivity over sigma receptors.
Jeffrey Schoellerman, Brian Lord, Anindya Bhattacharya, Brice Stenne, Jessica L Wall, Pascal Bonaventure

J Neurochem· September 2024

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In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B.
Davia Prischich, Rosalba Sortino, Alexandre Gomila-Juaneda, Carlo Matera, Salvador Guardiola, Pascal Bonaventure

Cell Mol Life Sci· July 2024

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Characterization of Selective M Acetylcholine Muscarinic Receptor Modulators on Dopamine Signaling in the Striatum.
Vivien Zell, Greetje Teuns, Alexandra Stormy Needham, Sruti Mukherjee, Nathaniel Roscoe, Pascal Bonaventure

J Pharmacol Exp Ther· November 2023

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Identification and characterization of select oxysterols as ligands for GPR17.
Anthony W Harrington, Changlu Liu, Naomi Phillips, Diane Nepomuceno, Chester Kuei, Pascal Bonaventure

Br J Pharmacol· February 2023

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Discovery and SAR studies of 2-alkyl-3-phenyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepines as 5-HT inhibitors leading to the identification of a clinical candidate.
Curt A Dvorak, Dale A Rudolph, Diane Nepomuceno, Lisa Dvorak, Brian Lord, Pascal Bonaventure

Bioorg Med Chem Lett· January 2021

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Screening for modulators of neural network activity in 3D human iPSC-derived cortical spheroids.
Grace Woodruff, Naomi Phillips, Cassiano Carromeu, Oivin Guicherit, Alistair White, Pascal Bonaventure

PLoS One· December 2020

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Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793.
Cathy Préville, Pascal Bonaventure, Tatiana Koudriakova, Brian Lord, Diane Nepomuceno

ACS Med Chem Lett· October 2020

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Putative role of GPR139 on sleep modulation using pharmacological and genetic rodent models.
Lien Wang, Christine Dugovic, Sujin Yun, Allison White, Brian Lord, Pascal Bonaventure

Eur J Pharmacol· September 2020

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Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans.
Giacomo Salvadore, Pascal Bonaventure, Anantha Shekhar, Philip L Johnson, Brian Lord

Transl Psychiatry· September 2020

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Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor.
Ryan M Wyatt, Ian Fraser, Natalie Welty, Brian Lord, Michelle Wennerholm, Pascal Bonaventure

J Pharmacol Exp Ther· March 2020

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Calcium Imaging Reveals That Cortisol Treatment Reduces the Number of Place Cells in Thy1-GCaMP6f Transgenic Mice.
Tim Indersmitten, Michael J Schachter, Stephanie Young, Natalie Welty, Stephani Otte, Pascal Bonaventure

Front Neurosci· March 2019

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Characterization of a Selective, Orally Available, and Brain Penetrant Small Molecule GPR139 Agonist.
James R Shoblock, Natalie Welty, Ian Fraser, Ryan Wyatt, Brian Lord, Pascal Bonaventure

Front Pharmacol· March 2019

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GPR139 and Dopamine D2 Receptor Co-express in the Same Cells of the Brain and May Functionally Interact.
Lien Wang, Grace Lee, Chester Kuei, Xiang Yao, Anthony Harrington, Pascal Bonaventure

Front Neurosci· March 2019

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Mutagenesis of GPR139 reveals ways to create gain or loss of function receptors.
Lien Wang, Grace Lee, Amy Shih, Chester Kuei, Diane Nepomuceno, Pascal Bonaventure

Pharmacol Res Perspect· February 2019

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Orexin Depolarizes Central Amygdala Neurons via Orexin Receptor 1, Phospholipase C and Sodium-Calcium Exchanger and Modulates Conditioned Fear.
Erik T Dustrude, Izabela F Caliman, Cristian S Bernabe, Stephanie D Fitz, Laura A Grafe, Pascal Bonaventure

Front Neurosci· December 2018

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The Zinc Transporter SLC39A7 (ZIP7) Is Essential for Regulation of Cytosolic Zinc Levels.
Grace Woodruff, Christian G Bouwkamp, Femke M de Vrij, Timothy Lovenberg, Pascal Bonaventure

Mol Pharmacol· September 2018

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Utilizing Miniature Fluorescence Microscopy to Image Hippocampal Place Cell Ensemble Function in Thy1.GCaMP6f Transgenic Mice.
Tim Indersmitten, Tamara Berdyyeva, Leah Aluisio, Timothy Lovenberg, Pascal Bonaventure

Curr Protoc Pharmacol· September 2018

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Re-evaluation of Adrenocorticotropic Hormone and Melanocyte Stimulating Hormone Activation of GPR139 .
Diane Nepomuceno, Chester Kuei, Curt Dvorak, Timothy Lovenberg, Changlu Liu, Pascal Bonaventure

Front Pharmacol· March 2018

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4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate.
Michael A Letavic, Brad M Savall, Brett D Allison, Leah Aluisio, Jose Ignacio Andres, Pascal Bonaventure

J Med Chem· June 2017

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Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation.
Pascal Bonaventure, Christine Dugovic, Brock Shireman, Cathy Preville, Sujin Yun

Front Pharmacol· June 2017

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Selective Inhibition of Orexin-2 Receptors Prevents Stress-Induced ACTH Release in Mice.
Sujin Yun, Michelle Wennerholm, Jonathan E Shelton, Pascal Bonaventure, Michael A Letavic

Front Behav Neurosci· May 2017

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Corrigendum to "Hypothalamic orexin's role in exacerbated cutaneous vasodilation responses to an anxiogenic stimulus in a surgical menopause model" [Psychoneuroendocrinology 65 (2016) 127-137].
Lauren M Federici, Izabela Facco Caliman, Andrei I Molosh, Stephanie D Fitz, William A Truitt, Pascal Bonaventure

Psychoneuroendocrinology· November 2016

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Direct Imaging of Hippocampal Epileptiform Calcium Motifs Following Kainic Acid Administration in Freely Behaving Mice.
Tamara K Berdyyeva, E Paxon Frady, Jonathan J Nassi, Leah Aluisio, Yauheniya Cherkas, Pascal Bonaventure

Front Neurosci· March 2016

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