Publications by authors named "Pascal Champeroux"

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Modelling of clinical TQT studies outcomes from preclinical cardiovascular safety pharmacology studies using the one-step QTc model.
Pascal Champéroux, Raafat Fares, Derek Leishman

Front Pharmacol· October 2025

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In silico modelling of stroke volume, cardiac output and systemic vascular resistance in cardiovascular safety pharmacology studies by telemetry.
Pascal Champeroux, Jérôme Thireau, Jean-Yves Le Guennec, Raafat Fares

J Pharmacol Toxicol Methods· June 2024

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Simultaneous assessment of central nervous and respiratory systems using jacketed telemetry in socially-housed rats: Application of the "3Rs" principles in core battery safety pharmacology studies.
Raafat Fares, Pascal Champéroux

J Pharmacol Toxicol Methods· May 2023

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Contribution of haemodynamic side effects and associated autonomic reflexes to ventricular arrhythmias triggering by torsadogenic hERG blocking drugs.
Pascal Champéroux, Raafat Fares, Thierry Bastogne, Serge Richard, Jean-Yves Le Guennec

Br J Pharmacol· September 2022

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Cardiovascular mechanisms underlying vocal behavior in freely moving macaque monkeys.
Cristina Risueno-Segovia, Okan Koç, Pascal Champéroux, Steffen R Hage

iScience· January 2022

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Relevance of electroencephalogram assessment in amyloid and tau pathology in rat.
Vincent Maleysson, Guylène Page, Thierry Janet, Ronald L Klein, Obélia Haida, Pascal Champeroux

Behav Brain Res· February 2019

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High-frequency autonomic modulation: a new model for analysis of autonomic cardiac control.
Pascal Champéroux, Pierre Fesler, Sebastien Judé, Serge Richard, Jean-Yves Le Guennec

Br J Pharmacol· August 2018

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Social housing of non-rodents during cardiovascular recordings in safety pharmacology and toxicology studies.
Helen Prior, Anna Bottomley, Pascal Champéroux, Jason Cordes, Eric Delpy

J Pharmacol Toxicol Methods· May 2017

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Corrigendum: Inter-individual variability and modeling of electrical activity: a possible new approach to explore cardiac safety?
Jean-Yves Le Guennec, Jérôme Thireau, Aude Ouillé, Julien Roussel, Jérôme Roy

Sci Rep· February 2017

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Inter-individual variability and modeling of electrical activity: a possible new approach to explore cardiac safety?
Jean-Yves Le Guennec, Jérôme Thireau, Aude Ouillé, Julien Roussel, Jérôme Roy

Sci Rep· November 2016

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The Complex QT/RR Relationship in Mice.
Julien Roussel, Pascal Champeroux, Jérôme Roy, Sylvain Richard, Jérémy Fauconnier

Sci Rep· May 2016

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Preclinical QT safety assessment: cross-species comparisons and human translation from an industry consortium.
Henry Holzgrefe, Georg Ferber, Pascal Champeroux, Michael Gill, Masaki Honda

J Pharmacol Toxicol Methods· September 2014

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Power spectral analysis of heart rate variability in cynomolgus monkeys in safety pharmacology studies: comparative study with beagle dogs.
Pascal Champeroux, Eric Martel, Sebastien Jude, Christine Laigot, Arnaud Laveissière

J Pharmacol Toxicol Methods· February 2014

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Comparison of high-definition oscillometry -- a non-invasive technology for arterial blood pressure measurement -- with a direct invasive method using radio-telemetry in awake healthy cats.
Eric Martel, Beate Egner, Scott A Brown, Jonathan N King, Arnaud Laveissiere, Pascal Champeroux

J Feline Med Surg· December 2013

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The authors respond.
Eric Martel, Beate Egner, Scott A Brown, Jonathan N King, Arnaud Laveissiere, Pascal Champeroux

J Feline Med Surg· December 2013

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Reducing endothelial NOS activation and interstitial fluid pressure with n-3 PUFA offset tumor chemoresistance.
Sophie Kornfeld, Caroline Goupille, Sophie Vibet, Stephan Chevalier, Amandine Pinet, Pascal Champeroux

Carcinogenesis· February 2012

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A step towards characterisation of electrophysiological profile of torsadogenic drugs.
Pascal Champeroux, Aude Ouillé, Eric Martel, John Sinclair Lawrence Fowler, Anne Maurin

J Pharmacol Toxicol Methods· August 2011

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Interferences of the autonomic nervous system with drug induced QT prolongation: a point to consider in non-clinical safety studies.
Pascal Champeroux, Aude Ouillé, Eric Martel, John Sinclair Lawrence Fowler, Anne Maurin

J Pharmacol Toxicol Methods· December 2010

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Calculation of QT shift in non clinical safety pharmacology studies.
Pascal Champeroux, Eric Martel, John Sinclair Lawrence Fowler, Anne Maurin, Marie Laure Sola

J Pharmacol Toxicol Methods· June 2009

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An optimised methodology for the neurobehavioural assessment in rodents.
Elena Moscardo, Anne Maurin, Roberto Dorigatti, Pascal Champeroux, Serge Richard

J Pharmacol Toxicol Methods· February 2008

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Electrophysiological profile of propiverine--relationship to cardiac risk.
Torsten Christ, Erich Wettwer, Melinda Wuest, Manfred Braeter, Frank Donath, Pascal Champeroux

Naunyn Schmiedebergs Arch Pharmacol· February 2008

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Dietary long-chain n-3 fatty acids modify blood and cardiac phospholipids and reduce protein kinase-C-delta and protein kinase-C-epsilon translocation.
Sébastien Judé, Eric Martel, Fanny Vincent, Pierre Besson, Charles Couet, Pascal Champeroux

Br J Nutr· December 2007

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Cardiovascular safety of gadoterate meglumine (Gd-DOTA).
Philippe Bourrinet, Eric Martel, Abdel I El Amrani, Pascal Champeroux, Serge Richard

Invest Radiol· February 2007

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Sensitization by dietary docosahexaenoic acid of rat mammary carcinoma to anthracycline: a role for tumor vascularization.
Séverine Colas, Karine Mahéo, Fabrice Denis, Caroline Goupille, Claude Hoinard, Pascal Champeroux

Clin Cancer Res· October 2006

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Dietary long-chain omega-3 fatty acids of marine origin: a comparison of their protective effects on coronary heart disease and breast cancers.
Sébastien Judé, Sébastien Roger, Eric Martel, Pierre Besson, Serge Richard, Pascal Champeroux

Prog Biophys Mol Biol· April 2006

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