Publications by authors named "Pascal G George"

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Design and synthesis of a novel series of histamine H3 receptor antagonists through a scaffold hopping strategy.
Zhongli Gao, William J Hurst, Daniel Hall, Ryan Hartung, William Reynolds, Pascal G George

Bioorg Med Chem· February 2015

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Identification and profiling of 3,5-dimethyl-isoxazole-4-carboxylic acid [2-methyl-4-((2S,3'S)-2-methyl-[1,3']bipyrrolidinyl-1'-yl)phenyl] amide as histamine H(3) receptor antagonist for the treatment of depression.
Zhongli Gao, William J Hurst, Werngard Czechtizky, Daniel Hall, Nicolas Moindrot, Pascal G George

Bioorg Med Chem Lett· December 2013

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Discovery of a potent, selective, and orally bioavailable histamine H3 receptor antagonist SAR110068 for the treatment of sleep-wake disorders.
Zhongli Gao, William J Hurst, Werngard Czechtizky, Dominique Francon, Guy Griebel, Pascal G George

Bioorg Med Chem Lett· November 2013

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Synthesis, characterization, and biological assessment of the four stereoisomers of the H(3) receptor antagonist 5-fluoro-2-methyl-N-[2-methyl-4-(2-methyl[1,3']bipyrrolidinyl-1'-yl)phenyl]benzamide.
Zhongli Gao, William J Hurst, Etienne Guillot, Raisa Nagorny, Marie-Pierre Pruniaux, Pascal G George

Bioorg Med Chem Lett· July 2013

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Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (part I).
Zhongli Gao, William J Hurst, Etienne Guillot, Werngard Czechtizky, Ulrike Lukasczyk, Pascal G George

Bioorg Med Chem Lett· June 2013

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Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (part II).
Zhongli Gao, William J Hurst, Etienne Guillot, Werngard Czechtizky, Ulrike Lukasczyk, Pascal G George

Bioorg Med Chem Lett· June 2013

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