Publications by authors named "Pascal Villa"

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Targeted isolation of new antibacterial sesquiterpene coumarins from ammoniacum (Ferula communis L.).
Capucine Braillon, Elora Aubert, Régine Janet-Bintz, Megi Gjikolaj, Rania Hamidi, Pascal Villa

Fitoterapia· October 2025

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Click-Functionalized Cyanine Fluorogenic Dimers for Improved Detection of GPCRs: Application to Imaging of ApelinR in Living Cells.
Océane Florès, Yann Berthomé, Lucille Weiss, Sarah Griesbaum-Dubourg, Stéphanie Riché, Pascal Villa

Chemistry· June 2025

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Rational Design of Cyanine-Based Fluorogenic Dimers to Reduce Nonspecific Interactions with Albumin and Lipid Bilayers: Application to Highly Sensitive Imaging of GPCRs in Living Cells.
Yann Berthomé, Julie Gerber, Fabien Hanser, Stéphanie Riché, Nicolas Humbert, Pascal Villa

Bioconjug Chem· August 2024

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Characterization of anti-GASP motif antibodies that inhibit the interaction between GPRASP1 and G protein-coupled receptors.
Gabrielle Zeder-Lutz, Olivier Bornert, Rosine Fellmann-Clauss, Adeline Knittel-Obrecht, Thibaud Tranchant, Pascal Villa

Anal Biochem· March 2023

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Rapid and Highly Selective Fluorescent Labeling of Peptides via a Thia-Diels-Alder Cycloaddition: Application to Apelin.
Timothé Maujean, Patrick Wagner, Christel Valencia, Stéphanie Riché, Xavier Iturrioz, Pascal Villa

Bioconjug Chem· January 2023

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Engineering Novel 3D Models to Recreate High-Grade Osteosarcoma and its Immune and Extracellular Matrix Microenvironment.
Marina Pierrevelcin, Vincent Flacher, Christopher G Mueller, Romain Vauchelles, Eric Guerin, Pascal Villa

Adv Healthc Mater· October 2022

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Target-Focused Library Design by Pocket-Applied Computer Vision and Fragment Deep Generative Linking.
Merveille Eguida, Christel Schmitt-Valencia, Marcel Hibert, Pascal Villa, Didier Rognan

J Med Chem· October 2022

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Treating leishmaniasis in Amazonia, part 2: Multi-target evaluation of widely used plants to understand medicinal practices.
Emeline Houël, Marine Ginouves, Nadine Azas, Eliane Bourreau, Véronique Eparvier, Pascal Villa

J Ethnopharmacol· May 2022

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Antiallodynic action of phosphodiesterase inhibitors in a mouse model of peripheral nerve injury.
Salim Megat, Sylvain Hugel, Sarah H Journée, Yohann Bohren, Adrien Lacaud, Pascal Villa

Neuropharmacology· March 2022

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High-Throughput Screening for Extracellular Inhibitors of the FLT3 Receptor Tyrosine Kinase Reveals Chemically Diverse and Druggable Negative Allosteric Modulators.
Romain Hany, Jean-Philippe Leyris, Guillaume Bret, Sylvie Mallié, Chamroeun Sar, Pascal Villa

ACS Chem Biol· March 2022

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Liposomal encapsulation of trans-crocetin enhances oxygenation in patients with COVID-19-related ARDS receiving mechanical ventilation.
Paul-Michel Mertes, Olivier Collange, Pierre Coliat, Mainak Banerjee, Marie-Charlotte Diringer, Pascal Villa

J Control Release· August 2021

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Overexpression of the MSK1 Kinase in Patients With Chronic Lung Allograft Dysfunction and Its Confirmed Role in a Murine Model.
Simona Nemska, François Daubeuf, Adeline Obrecht, Dominique Israel-Biet, Marc Stern, Pascal Villa

Transplantation· June 2021

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Nile Red-Based GPCR Ligands as Ultrasensitive Probes of the Local Lipid Microenvironment of the Receptor.
Fabien Hanser, Claire Marsol, Christel Valencia, Pascal Villa, Andrey S Klymchenko

ACS Chem Biol· April 2021

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Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model.
Maud Bollenbach, Simona Nemska, Patrick Wagner, Guillaume Camelin, François Daubeuf, Pascal Villa

Molecules· January 2021

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Anti-Inflammatory, Antioxidant, and Wound-Healing Properties of Cyanobacteria from Thermal Mud of Balaruc-Les-Bains, France: A Multi-Approach Study.
Justine Demay, Sébastien Halary, Adeline Knittel-Obrecht, Pascal Villa, Charlotte Duval

Biomolecules· December 2020

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Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime.
André-Guilhem Calas, Anne-Sophie Hanak, Nina Jaffré, Aurélie Nervo, José Dias, Pascal Villa

Biomolecules· June 2020

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Hypoxic Environment and Paired Hierarchical 3D and 2D Models of Pediatric -Mutated Gliomas Recreate the Patient Tumor Complexity.
Anne-Florence Blandin, Aurélie Durand, Marie Litzler, Aurélien Tripp, Éric Guérin, Pascal Villa

Cancers (Basel)· November 2019

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SynAggreg: A Multifunctional High-Throughput Technology for Precision Study of Amyloid Aggregation and Systematic Discovery of Synergistic Inhibitor Compounds.
Hubert Aviolat, Yves Nominé, Sophie Gioria, Anna Bonhoure, David Hoffmann, Pascal Villa

J Mol Biol· December 2018

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LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism.
Marie-Céline Frantz, Lucie P Pellissier, Elsa Pflimlin, Stéphanie Loison, Jorge Gandía, Pascal Villa

J Med Chem· October 2018

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Discovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia.
Pierre Regenass, Dayana Abboud, François Daubeuf, Christine Lehalle, Patrick Gizzi, Pascal Villa

J Med Chem· September 2018

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WNK1 kinase and its partners Akt, SGK1 and NBC-family Na/HCO3 cotransporters are potential therapeutic targets for glioblastoma stem-like cells linked to Bisacodyl signaling.
Wanyin Chen, Leonel Nguekeu Zebaze, Jihu Dong, Laëtitia Chézeau, Perrine Inquimbert, Pascal Villa

Oncotarget· June 2018

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Daunorubicin reduces MBNL1 sequestration caused by CUG-repeat expansion and rescues cardiac dysfunctions in a model of myotonic dystrophy.
Mouli Chakraborty, Chantal Sellier, Michel Ney, Villa Pascal, Nicolas Charlet-Berguerand

Dis Model Mech· April 2018

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Phenylpyridine-2-ylguanidines and rigid mimetics as novel inhibitors of TNFα overproduction: Beneficial action in models of neuropathic pain and of acute lung inflammation.
Maud Bollenbach, Eric Salvat, François Daubeuf, Patrick Wagner, Ipek Yalcin, Pascal Villa

Eur J Med Chem· March 2018

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A Time-Resolved FRET Cell-Based Binding Assay for the Apelin Receptor.
Christel Valencia, Céline Dujet, Jean-François Margathe, Xavier Iturrioz, Thomas Roux, Pascal Villa

ChemMedChem· June 2017

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Wayanin and guaijaverin, two active metabolites found in a Psidium acutangulum Mart. ex DC (syn. P. persoonii McVaugh) (Myrtaceae) antimalarial decoction from the Wayana Amerindians.
Emeline Houël, Flore Nardella, Valérie Jullian, Alexis Valentin, Catherine Vonthron-Sénécheau, Pascal Villa

J Ethnopharmacol· July 2016

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