Publications by authors named "Patrice Larger"

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Thiazole-Based IL-17 Inhibitors Discovered by Scaffold Morphing.
Juraj Velcicky, Estelle Ngo, Matthias R Bauer, Arndt Meyer, Achim Schlapbach, Patrice Larger

ChemMedChem· April 2025

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Identification of TAK-756, A Potent TAK1 Inhibitor for the Treatment of Osteoarthritis through Intra-Articular Administration.
Jean-Baptiste Langlois, Silke Brenneisen, Stephane Rodde, Eric Vangrevelinghe, Geoffroy Rose, Patrice Larger

J Med Chem· December 2024

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Discovery and Exploration of 1,3,4-Oxadiazole and α-Fluoroacrylate Containing IL-17 Inhibitors.
Juraj Velcicky, Matthias R Bauer, Achim Schlapbach, Guillaume Lapointe, Arndt Meyer, Patrice Larger

J Med Chem· September 2024

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Phase 1/2a trial of intravenous BAL101553, a novel controller of the spindle assembly checkpoint, in advanced solid tumours.
Rebecca Kristeleit, Jeffry Evans, L Rhoda Molife, Nina Tunariu, Heather Shaw, Patrice J Larger

Br J Cancer· October 2020

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A Phase 1 study of BAL101553, a novel tumor checkpoint controller targeting microtubules, administered as 48-h infusion in adult patients with advanced solid tumors.
Markus Joerger, Anastasios Stathis, Yannis Metaxas, Dagmar Hess, Mara Mantiero, Patrice Larger

Invest New Drugs· August 2020

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Variability and exposure-response relationships of isavuconazole plasma concentrations in the Phase 3 SECURE trial of patients with invasive mould diseases.
Thomas Kaindl, David Andes, Marc Engelhardt, Mikael Saulay, Patrice Larger

J Antimicrob Chemother· March 2019

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Discovery, synthesis, selectivity modulation and DMPK characterization of 5-azaspiro[2.4]heptanes as potent orexin receptor antagonists.
Luigi Piero Stasi, Roberto Artusi, Clara Bovino, Benedetta Buzzi, Luca Canciani, Patrice Larger

Bioorg Med Chem Lett· May 2013

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In vitro study of the inhibition and induction of human cytochromes P450 by crystalline glucosamine sulfate.
Stefano Persiani, Luca Canciani, Patrice Larger, Roberto Rotini, Giovanni Trisolino

Drug Metabol Drug Interact· July 2010

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Glucosamine binding to proteins in plasma and synovial fluid and blood cell/plasma partitioning in mouse and man in vitro.
Stefano Persiani, Anne Matthews, Patrice Larger, Michael Hall, Roberto Rotini

Drug Metabol Drug Interact· July 2010

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Strategies to assess the drug interaction potential in translational medicine.
Stefano Persiani, Patrice Larger

Expert Opin Drug Metab Toxicol· October 2006

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Ion-suppression effects in liquid chromatography-tandem mass spectrometry due to a formulation agent, a case study in drug discovery bioanalysis.
Patrice J Larger, Massimo Breda, Daniela Fraier, Heather Hughes, Christopher A James

J Pharm Biomed Anal· September 2005

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Simultaneous LC-MS/MS determination of reference pharmaceuticals as a method for the characterization of the Caco-2 cell monolayer absorption properties.
Patrice Larger, Maria Altamura, Rose-Marie Catalioto, Sandro Giuliani, Carlo Alberto Maggi

Anal Chem· October 2002

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