Publications by authors named "Patrick A Frantom"

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Characterization of a mechanistic connection between persulfide transfer and ATP hydrolysis in the SufBC2D scaffold of the Suf Fe-S cluster assembly pathway.
Nidhi Chhikara, Grishma Timilsina, Yu Wang, Dexter Reasons, F Wayne Outten, Patrick A Frantom

Metallomics· August 2025

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A Role for Two Conserved Arginine Residues in Protected Persulfide Transfer by SufE-Dependent SufS Cysteine Desulfurases.
Rajleen K Gogar, Juliana V Conte, Nidhi Chhikara, Jack A Dunkle, Patrick A Frantom

Biochemistry· June 2025

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Two conserved arginine residues facilitate C-S bond cleavage and persulfide transfer in Suf family cysteine desulfurases.
Rajleen K Gogar, Juliana V Conte, Jack A Dunkle, Patrick A Frantom

bioRxiv· October 2024

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The structure of the SufS-SufE complex reveals interactions driving protected persulfide transfer in iron-sulfur cluster biogenesis.
Rajleen K Gogar, Nidhi Chhikara, Minh Vo, Nathaniel C Gilbert, Jack A Dunkle, Patrick A Frantom

J Biol Chem· September 2024

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Persulfide Transfer to SufE Activates the Half-Sites Reactivity of the Cysteine Desulfurase SufS.
Rajleen K Gogar, Patrick A Frantom

Biochemistry· June 2024

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The structure of the SufS-SufE complex reveals interactions driving protected persulfide transfer in iron-sulfur cluster biogenesis.
Rajleen K Gogar, Nidhi Chhikara, Minh Vo, Nathaniel C Gilbert, Jack A Dunkle, Patrick A Frantom

bioRxiv· May 2024

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In Vitro and In Silico Explorations of the Protein Conformational Changes of Corynebacterium glutamicum MshA, a Model Retaining GT-B Glycosyltransferase.
Bakar A Hassan, Jozafina Milicaj, Meka Tyson, Ramesh Karki, Yuk Y Sham, Patrick A Frantom

Biochemistry· April 2024

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HDX-MS Reveals Substrate-Dependent, Localized EX1 Conformational Dynamics in the Retaining GT-B Glycosyltransferase, MshA.
Ramesh Karki, Jacquelyn T Hennek, Wen Chen, Patrick A Frantom

Biochemistry· September 2023

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Identification and analysis of small molecule inhibitors of FosB from .
Skye Travis, Keith D Green, Nishad Thamban Chandrika, Allan H Pang, Patrick A Frantom

RSC Med Chem· May 2023

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The β-latch structural element of the SufS cysteine desulfurase mediates active site accessibility and SufE transpersulfurase positioning.
Rajleen K Gogar, Franki Carroll, Juliana V Conte, Mohamed Nasef, Jack A Dunkle, Patrick A Frantom

J Biol Chem· March 2023

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Low-molecular-weight chromium-binding substance (LMWCr) may bind and carry Cr(III) from the endosome.
Kyle C Edwards, Michael W Gannon, Patrick A Frantom, John B Vincent

J Inorg Biochem· October 2021

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Biochemical characterization of 2-phosphinomethylmalate synthase from Streptomyces hygroscopicus: A member of the DRE-TIM metallolyase superfamily.
Juliana V Conte, Patrick A Frantom

Arch Biochem Biophys· September 2020

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Structural evidence for a latch mechanism regulating access to the active site of SufS-family cysteine desulfurases.
Jack A Dunkle, Michael R Bruno, Patrick A Frantom

Acta Crystallogr D Struct Biol· March 2020

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Characterization of the genomically encoded fosfomycin resistance enzyme from .
Skye Travis, Madeline R Shay, Shino Manabe, Nathaniel C Gilbert, Patrick A Frantom

Medchemcomm· November 2019

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Direct observation of intermediates in the SufS cysteine desulfurase reaction reveals functional roles of conserved active-site residues.
Matthew Blahut, Courtney E Wise, Michael R Bruno, Guangchao Dong, Thomas M Makris, Patrick A Frantom

J Biol Chem· August 2019

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Distinct mechanisms of substrate selectivity in the DRE-TIM metallolyase superfamily: A role for the LeuA dimer regulatory domain.
Wen Chen, Patrick A Frantom

Arch Biochem Biophys· March 2019

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Structural Evidence for Dimer-Interface-Driven Regulation of the Type II Cysteine Desulfurase, SufS.
Jack A Dunkle, Michael R Bruno, F Wayne Outten, Patrick A Frantom

Biochemistry· February 2019

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Changes in Protein Dynamics in Escherichia coli SufS Reveal a Possible Conserved Regulatory Mechanism in Type II Cysteine Desulfurase Systems.
Dokyong Kim, Harsimran Singh, Yuyuan Dai, Guangchao Dong, Laura S Busenlehner, Patrick A Frantom

Biochemistry· September 2018

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Improving Functional Annotation in the DRE-TIM Metallolyase Superfamily through Identification of Active Site Fingerprints.
Garima Kumar, Jordyn L Johnson, Patrick A Frantom

Biochemistry· March 2016

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SufE D74R Substitution Alters Active Site Loop Dynamics To Further Enhance SufE Interaction with the SufS Cysteine Desulfurase.
Yuyuan Dai, Dokyong Kim, Guangchao Dong, Laura S Busenlehner, Patrick A Frantom

Biochemistry· August 2015

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Biochemical characterization of the retaining glycosyltransferase glucosyl-3-phosphoglycerate synthase from Mycobacterium tuberculosis.
Garima Kumar, Siqi Guan, Patrick A Frantom

Arch Biochem Biophys· December 2014

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An evolutionarily conserved alternate metal ligand is important for activity in α-isopropylmalate synthase from Mycobacterium tuberculosis.
Patrick A Frantom, Yuliya Birman, Brittani N Hays, Ashley K Casey

Biochim Biophys Acta· October 2014

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Evolutionarily distinct versions of the multidomain enzyme α-isopropylmalate synthase share discrete mechanisms of V-type allosteric regulation.
Garima Kumar, Patrick A Frantom

Biochemistry· July 2014

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Mechanistic and bioinformatic investigation of a conserved active site helix in α-isopropylmalate synthase from Mycobacterium tuberculosis, a member of the DRE-TIM metallolyase superfamily.
Ashley K Casey, Michael A Hicks, Jordyn L Johnson, Patricia C Babbitt, Patrick A Frantom

Biochemistry· May 2014

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V-type allosteric inhibition is described by a shift in the rate-determining step for α-isopropylmalate synthase from Mycobacterium tuberculosis.
Ashley K Casey, Erica L Schwalm, Brittani N Hays, Patrick A Frantom

Biochemistry· October 2013

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