Publications by authors named "Patrick A Lewis"

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GPNMB is a biomarker for lysosomal dysfunction and is secreted via LRRK2-modulated lysosomal exocytosis.
Erin C Bogacki, Gustavo Morrone Parfitt, Adriana Cunha, George Longmore, Selina Wray, Patrick A Lewis

Sci Adv· December 2025

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Glutamic Acid at Position 168 Is a Constitutive Activator of Tank Binding Kinase 1 Catalytic Function.
Noopur Bhore, Anubhuti Sarkar, Zhi Yao, Susanne Herbst, Patrick A Lewis

Neuromolecular Med· November 2025

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New Frontiers in Animal Prion Diseases.
Hasina Abdul, Timm Konold, John Spiropoulos, Patrick A Lewis

Annu Rev Anim Biosci· November 2025

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Variants in the proteasome regulator PSMF1 cause a phenotypic spectrum from early-onset Parkinson's disease to perinatal lethality and disrupt mitochondrial function.
Francesca Magrinelli, Christelle Tesson, Plamena R Angelova, Jose A Rodriguez, Annarita Scardamaglia, Patrick A Lewis

medRxiv· July 2025

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Loss-of-function coding variants in the Ras of complex proteins/GTPase domain of leucine rich repeat kinase 2.
Sarah Butterfield, Susanne Herbst, Patrick Alfryn Lewis

Protein Sci· July 2025

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Reduction of Z alpha-1 antitrypsin polymers in human iPSC-hepatocytes and mice by LRRK2 inhibitors.
Deniz Kent, Soon Seng Ng, Adam M Syanda, Payam Khoshkenar, Riccardo Ronzoni, Patrick A Lewis

Hepatology· March 2025

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Robert Carswell and his depiction of sclerotic plaques.
Patrick A Lewis

Mult Scler Relat Disord· November 2024

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Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia.
Charles Arber, Jackie M Casey, Samuel Crawford, Naiomi Rambarack, Umran Yaman, Patrick A Lewis

Acta Neuropathol· November 2024

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Transcriptomics and weighted protein network analyses of the LRRK2 protein interactome reveal distinct molecular signatures for sporadic and LRRK2 Parkinson's Disease.
Yibo Zhao, Matthew Bracher-Smith, Yuelin Li, Kirsten Harvey, Valentina Escott-Price, Patrick A Lewis

NPJ Parkinsons Dis· August 2024

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LRRK2 kinase activity is necessary for development and regeneration in Nematostella vectensis.
Grace Holmes, Sophie R Ferguson, Patrick Alfryn Lewis, Karen Echeverri

Neural Dev· August 2024

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Common genetic risk for Parkinson's disease and dysfunction of the endo-lysosomal system.
Noopur Bhore, Erin C Bogacki, Benjamin O'Callaghan, Helene Plun-Favreau, Patrick A Lewis

Philos Trans R Soc Lond B Biol Sci· April 2024

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Artificial intelligence for neurodegenerative experimental models.
Sarah J Marzi, Brian M Schilder, Alexi Nott, Carlo Sala Frigerio, Sandrine Willaime-Morawek, Patrick A Lewis

Alzheimers Dement· December 2023

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Differential LRRK2 Signalling and Gene Expression in WT-LRRK2 and G2019S-LRRK2 Mouse Microglia Treated with Zymosan and MLi2.
Iqra Nazish, Adamantios Mamais, Anna Mallach, Conceicao Bettencourt, Alice Kaganovich, Patrick A Lewis

Cells· December 2023

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LRRK2 kinase activity is necessary for development and regeneration in Nematostella vectensis.
Grace Holmes, Sophie R Ferguson, Patrick Alfryn Lewis, Karen Echeverri

Res Sq· November 2023

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Protein network analysis links the NSL complex to Parkinson's disease mitochondrial and nuclear biology.
Katie Kelly, Patrick A Lewis, Helene Plun-Favreau, Claudia Manzoni

Mol Omics· September 2023

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Leucine-rich repeat kinase 2 at a glance.
Christiane Zhu, Susanne Herbst, Patrick A Lewis

J Cell Sci· September 2023

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Differential LRRK2 signalling and gene expression in WT-LRRK2 and G2019S-LRRK2 mouse microglia treated with zymosan and MLi2.
Iqra Nazish, Adamantios Mamais, Anna Mallach, Conceicao Bettencourt, Alice Kaganovich, Patrick A Lewis

bioRxiv· September 2023

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Microglia produce the amyloidogenic ABri peptide in familial British dementia.
Charles Arber, Jackie M Casey, Samuel Crawford, Naiomi Rambarack, Umran Yaman, Patrick A Lewis

bioRxiv· June 2023

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Tissue specific LRRK2 interactomes reveal a distinct striatal functional unit.
Yibo Zhao, Nikoleta Vavouraki, Ruth C Lovering, Valentina Escott-Price, Kirsten Harvey, Patrick A Lewis

PLoS Comput Biol· January 2023

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Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson's disease at 16q11.2 and MAPT H1 loci.
Marc P M Soutar, Daniela Melandri, Benjamin O'Callaghan, Emily Annuario, Amy E Monaghan, Patrick A Lewis

Brain· December 2022

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Cytosolic sequestration of spatacsin by Protein Kinase A and 14-3-3 proteins.
Susanna Cogo, James E Tomkins, Nikoleta Vavouraki, Veronica Giusti, Federica Forcellato, Patrick A Lewis

Neurobiol Dis· November 2022

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Lysosomal positioning regulates Rab10 phosphorylation at LRRK2 lysosomes.
Jillian H Kluss, Alexandra Beilina, Chad D Williamson, Patrick A Lewis, Mark R Cookson

Proc Natl Acad Sci U S A· October 2022

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The emerging role of LRRK2 in tauopathies.
Susanne Herbst, Patrick A Lewis, Huw R Morris

Clin Sci (Lond)· July 2022

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A step forward for LRRK2 inhibitors in Parkinson's disease.
Patrick A Lewis

Sci Transl Med· June 2022

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Seventy-Two-Hour LRRK2 Kinase Activity Inhibition Increases Lysosomal GBA Expression in H4, a Human Neuroglioma Cell Line.
Clara Ruz, José Luis Alcantud, Francisco Vives, Francisco Arrebola, John Hardy, Patrick A Lewis

Int J Mol Sci· June 2022

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