Publications by authors named "Patrick B Ryan"

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Comparative First-Line Effectiveness and Safety of ACE (Angiotensin-Converting Enzyme) Inhibitors and Angiotensin Receptor Blockers: A Multinational Cohort Study.
RuiJun Chen, Marc A Suchard, Harlan M Krumholz, Martijn J Schuemie, Steven Shea, Jon Duke, Nicole Pratt, Christian G Reich, David Madigan, Seng Chan You

Hypertension· September 2021

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Large-scale Empirical Identification of Candidate Comparators for Pharmacoepidemiological Studies.
Justin Bohn, James P Gilbert, Christopher Knoll, David M Kern, Patrick B Ryan

Drug Saf· November 2025

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Recommendations to Enable Broader Use of Real-World Evidence to Inform Decision-Making Throughout Pharmacovigilance Signal Management.
G Niklas Norén, Katherine Donegan, Monica A Muñoz, Thamir M Alshammari, Nicole Pratt, Patrick B Ryan

Pharmacoepidemiol Drug Saf· October 2025

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Evaluation of the impact of defining observable time in real-world data on outcome incidence.
Clair Blacketer, Frank J DeFalco, Mitchell M Conover, Patrick B Ryan, Martijn J Schuemie

J Am Med Inform Assoc· September 2025

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Risk of Thyroid Tumors With GLP-1 Receptor Agonists: A Retrospective Cohort Study.
Daniel R Morales, Fan Bu, Benjamin Viernes, Scott L DuVall, Michael E Matheny, Patrick B Ryan

Diabetes Care· August 2025

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Assessing Covariate Balance With Small Sample Sizes.
George Hripcsak, Linying Zhang, Yong Chen, Kelly Li, Marc A Suchard, Patrick B Ryan

Stat Med· August 2025

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Advancing Real-World Evidence Through a Federated Health Data Network (EHDEN): Descriptive Study.
Clair Blacketer, Martijn J Schuemie, Maxim Moinat, Erica A Voss, Montse Camprubi, Patrick B Ryan

J Med Internet Res· August 2025

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Assessing Covariate Balance with Small Sample Sizes.
George Hripcsak, Linying Zhang, Yong Chen, Kelly Li, Marc A Suchard, Patrick B Ryan

medRxiv· July 2025

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CohortDiagnostics: Phenotype evaluation across a network of observational data sources using population-level characterization.
Gowtham A Rao, Azza Shoaibi, Rupa Makadia, Jill Hardin, Joel Swerdel, Patrick B Ryan

PLoS One· May 2025

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Comparative Safety of Second-Line Antihyperglycemic Agents in Older Adults with Type 2 Diabetes: A Multinational Real-World Evidence From LEGEND-T2DM.
Chungsoo Kim, Fan Bu, Clair Blacketer, Anna Ostropolets, Talita Duarte-Salles, Patrick B Ryan

medRxiv· May 2025

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Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy.
Cindy X Cai, Michelle Hribar, Sally Baxter, Kerry Goetz, Swarup S Swaminathan, Patrick B Ryan

JAMA Ophthalmol· April 2025

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Can we develop real-world prognostic models using observational healthcare data? Large-scale experiment to investigate model sensitivity to database and phenotypes.
Jenna M Reps, Peter R Rijnbeek, Patrick B Ryan

Diagn Progn Res· April 2025

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Objective study validity diagnostics: a framework requiring pre-specified, empirical verification to increase trust in the reliability of real-world evidence.
Mitchell M Conover, Patrick B Ryan, Yong Chen, Marc A Suchard, George Hripcsak

J Am Med Inform Assoc· March 2025

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Risk of aortic aneurysm or dissection following use of fluoroquinolones: a retrospective multinational network cohort study.
Jack L Janetzki, Jung Ho Kim, Evan Minty, Jung Ah Lee, Daniel R Morales, Patrick B Ryan

EClinicalMedicine· March 2025

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Standardized patient profile review using large language models for case adjudication in observational research.
Martijn J Schuemie, Anna Ostropolets, Aleh Zhuk, Uladzislau Korsik, Seung In Seo, Patrick B Ryan

NPJ Digit Med· January 2025

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Glucagon-Like Peptide 1 Receptor Agonists and Chronic Lower Respiratory Disease Among Type 2 Diabetes Patients: Replication and Reliability Assessment Across a Research Network.
Mitchell M Conover, Yasser Albogami, Jill Hardin, Christian G Reich, Anna Ostropolets, Patrick B Ryan

Pharmacoepidemiol Drug Saf· January 2025

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Finding a constrained number of predictor phenotypes for multiple outcome prediction.
Jenna M Reps, Jenna Wong, Egill A Fridgeirsson, Chungsoo Kim, Luis H John, Patrick B Ryan

BMJ Health Care Inform· January 2025

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Comparative Effectiveness of Second-Line Antihyperglycemic Agents for Cardiovascular Outcomes: A Multinational, Federated Analysis of LEGEND-T2DM.
Rohan Khera, Arya Aminorroaya, Lovedeep Singh Dhingra, Phyllis M Thangaraj, Aline Pedroso Camargos, Patrick B Ryan

J Am Coll Cardiol· September 2024

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Similar Risk of Kidney Failure among Patients with Blinding Diseases Who Receive Ranibizumab, Aflibercept, and Bevacizumab: An Observational Health Data Sciences and Informatics Network Study.
Cindy X Cai, Akihiko Nishimura, Mary G Bowring, Erik Westlund, Diep Tran, Patrick B Ryan

Ophthalmol Retina· August 2024

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Development and validation of a patient-level model to predict dementia across a network of observational databases.
Luis H John, Egill A Fridgeirsson, Jan A Kors, Jenna M Reps, Ross D Williams, Patrick B Ryan

BMC Med· July 2024

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Authors' Response to Huang et al.'s Comment on "Serially Combining Epidemiological Designs Does Not Improve Overall Signal Detection in Vaccine Safety Surveillance".
Fan Bu, Faaizah Arshad, George Hripcsak, Patrick B Ryan, Martijn J Schuemie

Drug Saf· April 2024

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An open source knowledge graph ecosystem for the life sciences.
Tiffany J Callahan, Ignacio J Tripodi, Adrianne L Stefanski, Luca Cappelletti, Sanya B Taneja, Patrick B Ryan

Sci Data· April 2024

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Comparative Effectiveness of Second-line Antihyperglycemic Agents for Cardiovascular Outcomes: A Large-scale, Multinational, Federated Analysis of the LEGEND-T2DM Study.
Rohan Khera, Arya Aminorroaya, Lovedeep Singh Dhingra, Phyllis M Thangaraj, Aline Pedroso Camargos, Patrick B Ryan

medRxiv· February 2024

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Bayesian safety surveillance with adaptive bias correction.
Fan Bu, Martijn J Schuemie, Akihiko Nishimura, Louisa H Smith, Kristin Kostka, Patrick B Ryan

Stat Med· January 2024

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Evaluating the impact of alternative phenotype definitions on incidence rates across a global data network.
Rupa Makadia, Azza Shoaibi, Gowtham A Rao, Anna Ostropolets, Peter R Rijnbeek, Patrick B Ryan

JAMIA Open· December 2023

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Development and evaluation of an algorithm to link mothers and infants in two US commercial healthcare claims databases for pharmacoepidemiology research.
James Weaver, Jill H Hardin, Clair Blacketer, Alexis A Krumme, Melanie H Jacobson, Patrick B Ryan

BMC Med Res Methodol· October 2023

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