Publications by authors named "Patrick Deroy"

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Nickel-Catalyzed P-Arylation of HP(= O)(R/OR) Nucleophiles with (Hetero)Aryl Chlorides Enabled by DalPhos Ligation.
Michael J Cotnam, T Kieran Redpath, Catherine E Weetman, Patrick L DeRoy, David J Nelson

Chemistry· October 2025

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Development of Heteroaromatic Silicon Fluoride Acceptors (HetSiFAs) for F-Labeled Radiopharmaceuticals.
Thomas A Singleton, HyunJune Jun, Prashant S Deore, Carl Estrada, Bren Jordan P Atienza, Patrick L DeRoy

J Med Chem· August 2025

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Thermal Nickel-Catalyzed -Arylation of NH-Sulfoximines with (Hetero)aryl Chlorides Enabled by PhPAd-DalPhos Ligation.
Samuel A Fisher, Connor M Simon, Peter L Fox, Michael J Cotnam, Patrick L DeRoy

Org Lett· February 2024

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Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription.
Jenna K Rimel, Zachary C Poss, Benjamin Erickson, Zachary L Maas, Christopher C Ebmeier, Patrick DeRoy

Genes Dev· November 2020

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Electrolytic macrocyclizations: scalable synthesis of a diazonamide-based drug development candidate.
Hui Ding, Patrick L DeRoy, Christian Perreault, Alexandre Larivée, Arshad Siddiqui

Angew Chem Int Ed Engl· April 2015

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Identification of potent and orally bioavailable nucleotide competing reverse transcriptase inhibitors: in vitro and in vivo optimization of a series of benzofurano[3,2-d]pyrimidin-2-one derived inhibitors.
Claudio F Sturino, Yves Bousquet, Clint A James, Patrick DeRoy, Martin Duplessis

Bioorg Med Chem Lett· July 2013

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Identification of benzofurano[3,2-d]pyrimidin-2-ones, a new series of HIV-1 nucleotide-competing reverse transcriptase inhibitors.
Martin Tremblay, Richard C Bethell, Michael G Cordingley, Patrick DeRoy, Jianmin Duan

Bioorg Med Chem Lett· May 2013

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Nucleotide competing reverse transcriptase inhibitors: discovery of a series of non-basic benzofurano[3,2-d]pyrimidin-2-one derived inhibitors.
Clint A James, Patrick DeRoy, Martin Duplessis, Paul J Edwards, Teddy Halmos

Bioorg Med Chem Lett· May 2013

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Inhibition of HIV-1 capsid assembly: optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold.
Martin Tremblay, Pierre Bonneau, Yves Bousquet, Patrick DeRoy, Jianmin Duan

Bioorg Med Chem Lett· December 2012

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Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly.
Lee D Fader, Richard Bethell, Pierre Bonneau, Michael Bös, Yves Bousquet, Patrick Deroy

Bioorg Med Chem Lett· January 2011

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Chemical synthesis of 2beta-amino-5alpha-androstane-3alpha,17beta-diol N-derivatives and their antiproliferative effect on HL-60 human leukemia cells.
Dominic Thibeault, Jenny Roy, Patrick DeRoy, Donald Poirier

Bioorg Med Chem· May 2008

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Thiotetrazole alkynylacetanilides as potent and bioavailable non-nucleoside inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases.
Alexandre Gagnon, Ma'an H Amad, Pierre R Bonneau, René Coulombe, Patrick L DeRoy

Bioorg Med Chem Lett· August 2007

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2beta-(N-substituted piperazino)-5alpha-androstane-3alpha,17beta-diols: parallel solid-phase synthesis and antiproliferative activity on human leukemia HL-60 cells.
Jenny Roy, Patrick DeRoy, Donald Poirier

J Comb Chem· July 2007

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Efficient nucleophilic aromatic substitution between aryl nitrofluorides and alkynes.
Patrick L DeRoy, Simon Surprenant, Megan Bertrand-Laperle, Christiane Yoakim

Org Lett· July 2007

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Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency.
Pierre L Beaulieu, Michael Bös, Yves Bousquet, Patrick DeRoy, Gulrez Fazal

Bioorg Med Chem Lett· February 2004

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Total synthesis of (+)-cystothiazole A.
Patrick L DeRoy, André B Charette

Org Lett· October 2003

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