Publications by authors named "Patrick Gedeon"

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Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor that Unleashes PD-1 Checkpoint and CAR T-cell Immunotherapies.
Michael Wichroski, Si-Qi Liu, Lauren M Zasadil, Joseph L Benci, Patrick C Gedeon

Cancer Immunol Res· September 2025

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RNA sensing induced by chromosome missegregation augments anti-tumor immunity.
Nobunari Sasaki, Mizuki Homme, Takahiko Murayama, Tatsuya Osaki, Toshiyuki Tenma, Patrick C Gedeon

Mol Cell· February 2025

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The Role of Endobronchial Ultrasound for Mediastinal Staging in Mesothelioma.
Desiree Steimer, Peter Tramontozzi, Patrick Gedeon, Matthew Pommerening, Ariadne DeSimone

Ann Thorac Surg Short Rep· December 2024

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The Role of Antibody-Based Therapies in Neuro-Oncology.
Rishab Ramapriyan, Jing Sun, Annabel Curry, Leland G Richardson, Tarun Ramesh, Patrick C Gedeon

Antibodies (Basel)· November 2023

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Anatomy of the lung revisited by 3D-CT imaging.
Seshiru Nakazawa, Toshiteru Nagashima, Natsuko Kawatani, Patrick C Gedeon, Ariadne K DeSimone

Video Assist Thorac Surg· June 2023

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Clutch Control: Changing the Speed and Direction of CAR-T Cell Therapy.
Alberto Nobili, Aya Kobayashi, Patrick C Gedeon, Carl D Novina

J Cancer Immunol (Wilmington)· January 2022

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Checkpoint inhibitor immunotherapy for glioblastoma: current progress, challenges and future outlook.
Patrick C Gedeon, Cosette D Champion, Kristen E Rhodin, Karolina Woroniecka, Hanna R Kemeny

Expert Rev Clin Pharmacol· October 2020

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GLP toxicology study of a fully-human T cell redirecting CD3:EGFRvIII binding immunotherapeutic bispecific antibody.
Patrick C Gedeon, Michael A Streicker, Teilo H Schaller, Gary E Archer, Micheal P Jokinen

PLoS One· September 2020

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First in human dose calculation of a single-chain bispecific antibody targeting glioma using the MABEL approach.
Teilo H Schaller, David J Snyder, Ivan Spasojevic, Patrick C Gedeon, Luis Sanchez-Perez

J Immunother Cancer· April 2020

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Preventing Lck Activation in CAR T Cells Confers Treg Resistance but Requires 4-1BB Signaling for Them to Persist and Treat Solid Tumors in Nonlymphodepleted Hosts.
Carter M Suryadevara, Rupen Desai, S Harrison Farber, Bryan D Choi, Adam M Swartz, Patrick C Gedeon

Clin Cancer Res· January 2019

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A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma.
Patrick C Gedeon, Teilo H Schaller, Satish K Chitneni, Bryan D Choi, Chien-Tsun Kuan

Clin Cancer Res· August 2018

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Temozolomide lymphodepletion enhances CAR abundance and correlates with antitumor efficacy against established glioblastoma.
Carter M Suryadevara, Rupen Desai, Melissa L Abel, Katherine A Riccione, Kristen A Batich, Patrick C Gedeon

Oncoimmunology· February 2018

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Dendritic Cells Enhance Polyfunctionality of Adoptively Transferred T Cells That Target Cytomegalovirus in Glioblastoma.
Elizabeth A Reap, Carter M Suryadevara, Kristen A Batich, Luis Sanchez-Perez, Gary E Archer, Patrick C Gedeon

Cancer Res· January 2018

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Structure and Dynamics Study of LeuT Using the Markov State Model and Perturbation Response Scanning Reveals Distinct Ion Induced Conformational States.
Eliana K Asciutto, Patrick C Gedeon, Ignacio J General, Jeffry D Madura

J Phys Chem B· August 2016

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Accelerated molecular dynamics and protein conformational change: a theoretical and practical guide using a membrane embedded model neurotransmitter transporter.
Patrick C Gedeon, James R Thomas, Jeffry D Madura

Methods Mol Biol· June 2015

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Are BiTEs the "missing link" in cancer therapy?
Carter M Suryadevara, Patrick C Gedeon, Luis Sanchez-Perez, Terence Verla, Christopher Alvarez-Breckenridge

Oncoimmunology· June 2015

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Structural dynamics of the monoamine transporter homolog LeuT from accelerated conformational sampling and channel analysis.
James R Thomas, Patrick C Gedeon, Jeffry D Madura

Proteins· October 2014

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Epidermal growth factor receptor and variant III targeted immunotherapy.
Kendra L Congdon, Patrick C Gedeon, Carter M Suryadevara, Hillary G Caruso, Laurence J N Cooper

Neuro Oncol· October 2014

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Antibody-based immunotherapy for malignant glioma.
Patrick C Gedeon, Katherine A Riccione, Peter E Fecci, John H Sampson

Semin Oncol· August 2014

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Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma.
Bryan D Choi, Carter M Suryadevara, Patrick C Gedeon, James E Herndon, Luis Sanchez-Perez

J Clin Neurosci· January 2014

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Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody.
Bryan D Choi, Patrick C Gedeon, Luis Sanchez-Perez, Darell D Bigner, John H Sampson

Oncoimmunology· December 2013

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Rational design and generation of recombinant control reagents for bispecific antibodies through CDR mutagenesis.
Bryan D Choi, Patrick C Gedeon, Chien-Tsun Kuan, Luis Sanchez-Perez, Gary E Archer

J Immunol Methods· September 2013

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Human regulatory T cells kill tumor cells through granzyme-dependent cytotoxicity upon retargeting with a bispecific antibody.
Bryan D Choi, Patrick C Gedeon, James E Herndon, Gary E Archer, Elizabeth A Reap

Cancer Immunol Res· September 2013

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An EGFRvIII-targeted bispecific T-cell engager overcomes limitations of the standard of care for glioblastoma.
Patrick C Gedeon, Bryan D Choi, Tiffany R Hodges, Duane A Mitchell, Darell D Bigner

Expert Rev Clin Pharmacol· July 2013

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Rindopepimut: anti-EGFRvIII peptide vaccine, oncolytic.
Patrick C Gedeon, Bryan D Choi, John H Sampson, Darell D Bigner

Drugs Future· March 2013

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