Publications by authors named "Patrick Gilon"

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Adaptive mechanisms in pancreatic islets counteract mitochondrial dysfunction in Barth syndrome.
Christopher Carlein, Markus D A Hoffmann, Caroline Bickelmann, Andressa G Amaral, Ahmadali Lotfinia, Patrick Gilon

Diabetologia· January 2026

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3D evaluation of the extracellular matrix of hypoxic pancreatic islets using light sheet fluorescence microscopy.
Matias Ramirez, Estelle Bastien, Heeyoung Chae, Pierre Gianello, Patrick Gilon

Islets· December 2024

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The GHSR1a antagonist LEAP2 regulates islet hormone release in a sex-specific manner.
Nirun Hewawasam, Debalina Sarkar, Olivia Bolton, Blerinda Delishaj, Maha Almutairi, Patrick Gilon

J Endocrinol· November 2024

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Corrigendum to "Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells" [Mol Metab 2016 May; 5 (5): 366-378].
Tobias Boothe, Gareth E Lim, Haoning Cen, Søs Skovsø, Micah Piske, Patrick Gilon

Mol Metab· May 2024

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GLP-1 and GIP receptors signal through distinct β-arrestin 2-dependent pathways to regulate pancreatic β cell function.
Nour Zaïmia, Joelle Obeid, Annie Varrault, Julia Sabatier, Christophe Broca, Patrick Gilon

Cell Rep· November 2023

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ER stress increases expression of intracellular calcium channel RyR1 to modify Ca homeostasis in pancreatic beta cells.
Irina X Zhang, Andrea Herrmann, Juan Leon, Sivakumar Jeyarajan, Anoop Arunagiri, Patrick Gilon

J Biol Chem· August 2023

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GLP-1R agonists demonstrate potential to treat Wolfram syndrome in human preclinical models.
Vyron Gorgogietas, Bahareh Rajaei, Chae Heeyoung, Bruno J Santacreu, Sandra Marín-Cañas, Patrick Gilon

Diabetologia· July 2023

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Chemerin as an Inducer of β Cell Proliferation Mediates Mitochondrial Homeostasis and Promotes β Cell Mass Expansion.
Min Li, Ruifan Zhang, Qian Ge, Lingzhi Yue, Dan Ma, Patrick Gilon

Int J Mol Sci· May 2023

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Prolonged culture of human pancreatic islets under glucotoxic conditions changes their acute beta cell calcium and insulin secretion glucose response curves from sigmoid to bell-shaped.
Mohammad Tariq, Arnaldo H de Souza, Mohammed Bensellam, Heeyoung Chae, Manon Jaffredo, Patrick Gilon

Diabetologia· April 2023

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In depth functional characterization of human induced pluripotent stem cell-derived beta cells and .
Federica Fantuzzi, Sanna Toivonen, Andrea Alex Schiavo, Heeyoung Chae, Mohammad Tariq, Patrick Gilon

Front Cell Dev Biol· August 2022

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Glucose inhibits glucagon secretion by decreasing [Ca] and by reducing the efficacy of Ca on exocytosis via somatostatin-dependent and independent mechanisms.
Bilal Singh, Firas Khattab, Patrick Gilon

Mol Metab· July 2022

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The endoplasmic reticulum-plasma membrane tethering protein TMEM24 is a regulator of cellular Ca2+ homeostasis.
Beichen Xie, Styliani Panagiotou, Jing Cen, Patrick Gilon, Peter Bergsten

J Cell Sci· March 2022

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K channel blockers control glucagon secretion by distinct mechanisms: A direct stimulation of α-cells involving a [Ca] rise and an indirect inhibition mediated by somatostatin.
Bilal Singh, Firas Khattab, Heeyoung Chae, Lieven Desmet, Pedro L Herrera, Patrick Gilon

Mol Metab· November 2021

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LDHA is enriched in human islet alpha cells and upregulated in type 2 diabetes.
Paulina Karen Mendoza Sanchez, Mona Khazaei, Eva Gatineau, Shirin Geravandi, Blaz Lupse, Patrick Gilon

Biochem Biophys Res Commun· September 2021

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SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans.
Heeyoung Chae, Robert Augustin, Eva Gatineau, Eric Mayoux, Mohammed Bensellam, Patrick Gilon

Mol Metab· December 2020

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Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide.
Virginie Montiel, Ramona Bella, Lauriane Y M Michel, Hrag Esfahani, Delphine De Mulder, Patrick Gilon

Sci Transl Med· October 2020

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γ-Hydroxybutyrate does not mediate glucose inhibition of glucagon secretion.
Qian Yu, Bao Khanh Lai, Parvin Ahooghalandari, Anders Helander, Erik Gylfe, Patrick Gilon

J Biol Chem· April 2020

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The Role of α-Cells in Islet Function and Glucose Homeostasis in Health and Type 2 Diabetes.
Patrick Gilon

J Mol Biol· March 2020

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Metallothionein 1 negatively regulates glucose-stimulated insulin secretion and is differentially expressed in conditions of beta cell compensation and failure in mice and humans.
Mohammed Bensellam, Yan-Chuan Shi, Jeng Yie Chan, D Ross Laybutt, Heeyoung Chae, Patrick Gilon

Diabetologia· December 2019

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Glucose Acutely Reduces Cytosolic and Mitochondrial HO in Rat Pancreatic Beta Cells.
Jean-Philippe Deglasse, Leticia Prates Roma, Daniel Pastor-Flores, Patrick Gilon, Tobias P Dick

Antioxid Redox Signal· January 2019

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Somatostatin Is Only Partly Required for the Glucagonostatic Effect of Glucose but Is Necessary for the Glucagonostatic Effect of K Channel Blockers.
Bao-Khanh Lai, Heeyoung Chae, Ana Gómez-Ruiz, Panpan Cheng, Paola Gallo, Patrick Gilon

Diabetes· November 2018

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Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic β-Cell.
Tatsuyoshi Kono, Xin Tong, Solaema Taleb, Robert N Bone, Hitoshi Iida, Patrick Gilon

Diabetes· November 2018

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Identification of islet-enriched long non-coding RNAs contributing to β-cell failure in type 2 diabetes.
Anna Motterle, Sonia Gattesco, Marie-Line Peyot, Jonathan Lou S Esguerra, Ana Gomez-Ruiz, Patrick Gilon

Mol Metab· November 2017

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How stable is repression of disallowed genes in pancreatic islets in response to metabolic stress?
Katleen Lemaire, Mikaela Granvik, Anica Schraenen, Lotte Goyvaerts, Leentje Van Lommel, Patrick Gilon

PLoS One· October 2017

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TALK-1 channels control β cell endoplasmic reticulum Ca homeostasis.
Nicholas C Vierra, Prasanna K Dadi, Sarah C Milian, Matthew T Dickerson, Kelli L Jordan, Patrick Gilon

Sci Signal· September 2017

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