Publications by authors named "Patrick Johe"

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Two Tags in One Probe: Combining Fluorescence- and Biotin-based Detection of the Trypanosomal Cysteine Protease Rhodesain.
Carina Lemke, Adéla Jílková, Dominic Ferber, Annett Braune, Anja On, Patrick Johe

Chemistry· November 2022

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Structure, interdomain dynamics, and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes.
Patrick Johé, Elmar Jaenicke, Hannes Neuweiler, Tanja Schirmeister, Christian Kersten

J Biol Chem· August 2021

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Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure-Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies.
Sascha Jung, Natalie Fuchs, Patrick Johe, Annika Wagner, Erika Diehl

J Med Chem· August 2021

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Warhead Reactivity Limits the Speed of Inhibition of the Cysteine Protease Rhodesain.
Patrick Johe, Sascha Jung, Erik Endres, Christian Kersten, Collin Zimmer

ACS Chem Biol· April 2021

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Naphthoquinones as Covalent Reversible Inhibitors of Cysteine Proteases-Studies on Inhibition Mechanism and Kinetics.
Philipp Klein, Fabian Barthels, Patrick Johe, Annika Wagner, Stefan Tenzer

Molecules· April 2020

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New Cysteine Protease Inhibitors: Electrophilic (Het)arenes and Unexpected Prodrug Identification for the Protease Rhodesain.
Philipp Klein, Patrick Johe, Annika Wagner, Sascha Jung, Jonas Kühlborn

Molecules· March 2020

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Graphical Workflow System for Modification Calling by Machine Learning of Reverse Transcription Signatures.
Lukas Schmidt, Stephan Werner, Thomas Kemmer, Stefan Niebler, Marco Kristen, Patrick Johe

Front Genet· September 2019

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Dipeptidyl Nitroalkenes as Potent Reversible Inhibitors of Cysteine Proteases Rhodesain and Cruzain.
Antonio Latorre, Tanja Schirmeister, Jochen Kesselring, Sascha Jung, Patrick Johé

ACS Med Chem Lett· December 2016

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Quantum Chemical-Based Protocol for the Rational Design of Covalent Inhibitors.
Tanja Schirmeister, Jochen Kesselring, Sascha Jung, Thomas H Schneider, Anastasia Weickert

J Am Chem Soc· July 2016

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