Publications by authors named "Patrick Mathieu"

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Impact of the gut microbiota and associated metabolites on cardiometabolic traits, chronic diseases and human longevity: a Mendelian randomization study.
Eloi Gagnon, Patricia L Mitchell, Hasanga D Manikpurage, Erik Abner, Nele Taba, Tõnu Esko, Nooshin Ghodsian, Sébastien Thériault, Patrick Mathieu, Benoit J Arsenault

J Transl Med· January 2023

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Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction.
Aeron M Small, Ta-Yu Yang, Shinsuke Itoh, Sébastien Thériault, Line Dufresne, Patrick Mathieu

Nat Genet· December 2025

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Early-onset multivalvular disease caused by a missense variant in lamin A/C.
Alexandre Janin, Nathalie Gaudreault, Victoria Saavedra Armero, Zhonglin Li, Ran Xu, Patrick Mathieu

HGG Adv· October 2025

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A Transcriptomic Approach to Sex Differences in Calcific Aortic Valve Stenosis in Patients with a Tricuspid Aortic Valve.
Emma Le Nezet, Rose Tam, Zhonglin Li, Nathalie Gaudreault, Patrick Mathieu

CJC Open· August 2025

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Aortic valve-specific genes dysregulated in calcific aortic valve stenosis as potential biomarkers and therapeutic targets.
Pardis Zamani, Ursula Houessou, Hasanga D Manikpurage, Zhonglin Li, Manel Dahmene, Patrick Mathieu

HGG Adv· July 2025

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RNA interference versus antibody-based PCSK9 inhibition for the prevention of cardiovascular disease: a drug-target Mendelian randomization study.
Eloi Gagnon, Dipender Gill, Jérôme Bourgault, Émilie Gobeil, Patricia L Mitchell, Patrick Mathieu

Cardiovasc Res· July 2025

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Appraisal of multiple polygenic risk scores to estimate the risk of myocardial infarction and coronary artery lesions.
Hasanga D Manikpurage, Jérôme Bourgault, Ursula Houessou, Audrey Paulin, Pardis Zamani, Patrick Mathieu

Commun Med (Lond)· July 2025

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Transcriptomic Signatures of Calcific Aortic Valve Stenosis Severity in Human Tricuspid and Bicuspid Aortic Valves.
Ursula Houessou, Pardis Zamani, Hasanga D Manikpurage, Zhonglin Li, Nathalie Gaudreault, Patrick Mathieu

JACC Basic Transl Sci· June 2025

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Editorial Commentary to Mapping the Monogenic and Polygenic Architecture of Mitral Valve Prolapse.
Yohan Bossé, Sébastien Thériault, Patrick Mathieu

Can J Cardiol· May 2025

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RNA epigenetic modifications: a new field of research in calcific aortic valve disease.
Mewen Briend, Patrick Mathieu

Cardiovasc Res· April 2025

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Loss-of-Function in APOC3 and Protection Against Aortic Valve Disease.
Jérôme Bourgault, Anders Berg Wulff, Ursula Houessou, Hasanga D Manikpurage, Marie-Annick Clavel, Patrick Mathieu

J Am Coll Cardiol· April 2025

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Impact of Lipoprotein(a) on Valvular and Cardiovascular Outcomes in Patients With Calcific Aortic Valve Stenosis.
Arnaud S Girard, Audrey Paulin, Hasanga D Manikpurage, Emma Lajeunesse, Marie-Annick Clavel, Patrick Mathieu

J Am Heart Assoc· March 2025

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Visceral adiposity: A major mediator of the relationship between epicardial adiposity and cardiorespiratory fitness in adults.
Dominic J Chartrand, Eric Larose, Paul Poirier, Patrick Mathieu, Natalie Alméras

Nutr Metab Cardiovasc Dis· February 2025

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Association of genetically predicted levels of circulating blood lipids with coronary artery disease incidence.
Hasanga D Manikpurage, Jasmin Ricard, Ursula Houessou, Jérôme Bourgault, Eloi Gagnon, Patrick Mathieu

Atherosclerosis· February 2025

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Role of visceral adiposity in the relationship between cardiorespiratory fitness and liver fat in asymptomatic adults.
Dominic J Chartrand, Eric Larose, Paul Poirier, Patrick Mathieu, Natalie Alméras

Appl Physiol Nutr Metab· January 2025

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Lipoprotein(a) and Calcific Aortic Valve Stenosis Progression: A Systematic Review and Meta-Analysis.
Benoit J Arsenault, Krithika Loganath, Arnaud Girard, Simona Botezatu, Kang H Zheng, Patrick Mathieu

JAMA Cardiol· September 2024

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Combination of Waist Circumference and Circulating Levels of IGFBP-2 as a Simple Screening Tool for Early Detection of Metabolic Dysfunction-Associated Steatotic Liver Disease.
Chloé Rauzier, Dominic J Chartrand, Natalie Alméras, Isabelle Lemieux, Eric Larose, Patrick Mathieu

Diabetes Metab Syndr Obes· September 2024

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Polygenic inheritance and its interplay with smoking history in predicting lung cancer diagnosis: a French-Canadian case-control cohort.
Véronique Boumtje, Hasanga D Manikpurage, Zhonglin Li, Nathalie Gaudreault, Victoria Saavedra Armero, Mathieu Morissette, Patrick Mathieu

EBioMedicine· August 2024

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Mendelian randomization reveals interactions of the blood proteome and immunome in mitral valve prolapse.
Louis-Hippolyte Minvielle Moncla, Mewen Briend, Mame Sokhna Sylla, Samuel Mathieu, Anne Rufiange, Patrick Mathieu

Commun Med (Lond)· June 2024

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Single-cell and single-nucleus RNA-sequencing from paired normal-adenocarcinoma lung samples provide both common and discordant biological insights.
Sébastien Renaut, Victoria Saavedra Armero, Dominique K Boudreau, Nathalie Gaudreault, Patrice Desmeules, Patrick Mathieu

PLoS Genet· May 2024

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Genetic assessment of efficacy and safety profiles of coagulation cascade proteins identifies Factors II and XI as actionable anticoagulant targets.
Eloi Gagnon, Arnaud Girard, Jérôme Bourgault, Erik Abner, Dipender Gill, Patrick Mathieu

Eur Heart J Open· May 2024

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Genetic inhibition of angiopoietin-like protein-3, lipids, and cardiometabolic risk.
Émilie Gobeil, Jérôme Bourgault, Patricia L Mitchell, Ursula Houessou, Eloi Gagnon, Patrick Mathieu

Eur Heart J· March 2024

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Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation.
Sébastien Thériault, Zhonglin Li, Erik Abner, Jian'an Luan, Hasanga D Manikpurage, Patrick Mathieu

Nat Commun· March 2024

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Association between remnant cholesterol and progression of bioprosthetic valve degeneration.
Ziang Li, Bin Zhang, Erwan Salaun, Nancy Côté, Haifa Mahjoub, Patrick Mathieu

Eur Heart J Cardiovasc Imaging· November 2023

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Plasma IGFBP-2 levels reveal heterogeneity in hepatic fat content in adults with excess visceral adiposity.
Chloé Rauzier, Dominic J Chartrand, Natalie Alméras, Isabelle Lemieux, Eric Larose, Patrick Mathieu

Front Endocrinol (Lausanne)· November 2023

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Contribution of Lipoprotein(a) to Polygenic Risk Prediction of Coronary Artery Disease: A Prospective UK Biobank Analysis.
Hasanga D Manikpurage, Audrey Paulin, Arnaud Girard, Aida Eslami, Patrick Mathieu

Circ Genom Precis Med· October 2023

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