Publications by authors named "Patrick Sin-Chan"

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Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity.
Danielle Gutman, Gabriel Lidzbarsky, Sofiya Milman, Tina Gao, Patrick Sin-Chan, Claudia Gonzaga-Jauregui, , Joris Deelen, Alan R Shuldiner, Nir Barzilai

Aging Cell· October 2020

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Combining a deep learning model with clinical data better predicts hepatocellular carcinoma behavior following surgery.
Benoit Schmauch, Sarah S Elsoukkary, Amika Moro, Roma Raj, Chase J Wehrle, Patrick Sin-Chan

J Pathol Inform· December 2024

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Author Correction: Rare genetic coding variants associated with human longevity and protection against age-related diseases.
Jhih-Rong Lin, Patrick Sin-Chan, Valerio Napolioni, Guillermo G Torres, Joydeep Mitra

Nat Aging· September 2024

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Rare genetic coding variants associated with human longevity and protection against age-related diseases.
Jhih-Rong Lin, Patrick Sin-Chan, Valerio Napolioni, Guillermo G Torres, Joydeep Mitra

Nat Aging· September 2021

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A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor.
Patrick Sin-Chan, Iqra Mumal, Tannu Suwal, Ben Ho, Xiaolian Fan

Cancer Cell· July 2019

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Tails of a Super Histone.
Patrick Sin-Chan, Iqra Mumal, Annie Huang

Cancer Cell· January 2019

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Molecular Classification and Management of Rare Pediatric Embryonal Brain Tumors.
Patrick Sin-Chan, Bryan K Li, Ben Ho, Adriana Fonseca, Annie Huang

Curr Oncol Rep· July 2018

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Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.
Stephen C Mack, Kristian W Pajtler, Lukas Chavez, Konstantin Okonechnikov, Kelsey C Bertrand, Patrick Sin-Chan

Nature· January 2018

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Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.
Jonathon Torchia, Brian Golbourn, Shengrui Feng, King Ching Ho, Patrick Sin-Chan

Cancer Cell· December 2016

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Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis.
Jonathon Torchia, Daniel Picard, Lucie Lafay-Cousin, Cynthia E Hawkins, Seung-Ki Kim, Patrick Sin-Chan

Lancet Oncol· May 2015

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DNMTs as potential therapeutic targets in high-risk pediatric embryonal brain tumors.
Patrick Sin-Chan, Annie Huang

Expert Opin Ther Targets· October 2014

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CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity.
Tara Spence, Patrick Sin-Chan, Daniel Picard, Mark Barszczyk, Katharina Hoss

Acta Neuropathol· August 2014

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A novel C19MC amplified cell line links Lin28/let-7 to mTOR signaling in embryonal tumor with multilayered rosettes.
Tara Spence, Christian Perotti, Patrick Sin-Chan, Daniel Picard, Wei Wu

Neuro Oncol· January 2014

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Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR.
Claudia L Kleinman, Noha Gerges, Simon Papillon-Cavanagh, Patrick Sin-Chan, Albena Pramatarova

Nat Genet· January 2014

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