Aging Cell October 2020 PMID 32860726

Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity.

Danielle Gutman, Gabriel Lidzbarsky, Sofiya Milman, Tina Gao, Patrick Sin-Chan, Claudia Gonzaga-Jauregui, Joris Deelen, Alan R Shuldiner, Nir Barzilai, Gil Atzmon

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Mentions

51
Peak: 10 in Sep 2020
across 6 sources since Aug 2020

Extended reach

160,021
potential audience

Total likes

239

Video views

3,806

Mentions per month

Aug 2020 – Apr 2025

Where it's discussed

  • X / Twitter23 posts
  • News18 articles
  • Blogs4 articles
  • YouTube2 videos
  • Facebook2 posts
  • Reddit2 posts

AI synopsis

What people are saying

Discussions reflect a high level of interest and engagement, with posts highlighting key insights like the lack of fewer mutations in long-lived individuals, paralleling past studies and emphasizing the need to explore other genetic or lifestyle factors. Phrases such as 'supporting the dominance of longevity genes' and references to implications for aging research showcase a thoughtful and impactful dialogue surrounding the publication.

AgreementModerate agreement

Most discussions acknowledge and support the findings that longevity isn't solely determined by having fewer harmful genetic variants, often referencing previous research and reinforcing the study's conclusions.

InterestHigh interest

The talks demonstrate high curiosity about the genetics of longevity and aging, with many posts emphasizing the implications for understanding health in old age.

EngagementHigh engagement

Participants reference specific aspects of the research, such as the similar mutation burdens and the role of other factors, indicating deep engagement with the content.

ImpactModerate impact

The discourse suggests the findings could influence future research directions in aging genetics and challenge traditional views about genetic mutation burdens contributing to longevity.

Abstract in brief

  • Centenarians show a surprising longevity and health despite having similar genetic mutation burdens compared to their peers, revealed through whole exome sequencing of 1,879 individuals, including ELLI, their offspring, and controls.
  • Analyses found no significant differences in the types or frequencies of harmful genetic variants between centenarians and non-centenarian controls, indicating that being a centenarian is not linked to having fewer harmful mutations.
  • Notably, ELLI displayed a lower presence of cancer and Alzheimer’s-associated variants, hinting that their longevity may be influenced by other genomic or lifestyle factors rather than simply a lack of harmful mutations.

Top posts

Most liked on X and Bluesky
Michael Ristow, MD
@Prof_M_Ristow · X

Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional #longevity. #genetics #SNPs #polymorphism https://t.co/6xpFZp7BPK https://t.co/MOixH0Z2HG

Sep 23, 2020 · 9 likes · 6 shares · 6,984 followers View post →
Aging Science News
@AgingBiology · X

Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional longevity https://t.co/bVaVvgov57

Aug 30, 2020 · 8 likes · 4 shares · 30,819 followers View post →
Madam Mitochondria
@Madam_Mito · X

@adamgries @NobleDenis https://t.co/fELzcYFrP2

Apr 12, 2025 · 7 likes · 3 shares · 10,590 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional longevity https://t.co/0fHTpb2YDC

Aug 30, 2020 · 2 likes · 9,730 followers View post →
Agingdoc
@agingdoc1 · X

RT @Prof_M_Ristow: Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional…

Sep 23, 2020 · 6 shares · 41,947 followers View post →
Agingdoc
@agingdoc1 · X

Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity This replicated earlier work, also by Nir, supporting the dominance of longevity assurance genes in overcoming risk factors. https://t.co/tJNOpIwFLu

Aug 31, 2020 · 41,947 followers View post →

All mentions

NADIA EB
@NADYEUGENY · X

RT @Madam_Mito: @adamgries @NobleDenis https://t.co/fELzcYFrP2

Apr 12, 2025 · 3 shares · 213 followers View post →
Pieter Janssens
@pieter_mj_j · X

RT @Madam_Mito: @adamgries @NobleDenis https://t.co/fELzcYFrP2

Apr 12, 2025 · 3 shares · 287 followers View post →
Madam Mitochondria
@Madam_Mito · X

@adamgries @NobleDenis https://t.co/fELzcYFrP2

Apr 12, 2025 · 7 likes · 3 shares · 10,590 followers View post →
Alexander
@Alexand09896703 · X

LONGEVITY & AGING NEWS | Anti-aging In The News https://t.co/01WrWB9CO1 via @YouTube

Dec 1, 2021 · 106 followers View post →
LeapMind
@leapmind · X

Longevity and aging news Lance Hitchens https://t.co/E1CC2qXhLY

Oct 11, 2020 · 723 followers View post →
Eve.S.
@yeeseak · X

https://t.co/d6WVzCLgvx

Sep 26, 2020 · 892 followers View post →
S Rodriguez-Cuenca
@mynameiscormac · X

RT @Prof_M_Ristow: Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional…

Sep 23, 2020 · 6 shares · 500 followers View post →
Siegfried Hekimi
@SiegfriedHekimi · X

RT @Prof_M_Ristow: Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional…

Sep 23, 2020 · 6 shares · 721 followers View post →
Tim Moore
@tim_moore8 · X

RT @Prof_M_Ristow: Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional…

Sep 23, 2020 · 6 shares · 73 followers View post →
Agingdoc
@agingdoc1 · X

RT @Prof_M_Ristow: Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional…

Sep 23, 2020 · 6 shares · 41,947 followers View post →
Jamie Timmons
@metapredict · X

RT @Prof_M_Ristow: Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional…

Sep 23, 2020 · 6 shares · 2,060 followers View post →
Michael Ristow, MD
@Prof_M_Ristow · X

Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional #longevity. #genetics #SNPs #polymorphism https://t.co/6xpFZp7BPK https://t.co/MOixH0Z2HG

Sep 23, 2020 · 9 likes · 6 shares · 6,984 followers View post →
H+ Bot
@HplusBot · X

Check out "Centenarians do not carry fewer pathogenic mutations | Lifespan News" at: https://t.co/zOMqqIyws7

Sep 16, 2020 · 187 followers View post →
Orlando_uy
@Orlando_uy · X

Long Lived Humans Do Not Exhibit Fewer Harmful Gene Variants. https://t.co/RH57WVtohQ

Sep 9, 2020 · 694 followers View post →
Matt Yousefzadeh
@MattYousefzadeh · X

RT @AgingBiology: Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional…

Aug 31, 2020 · 4 shares · 4,792 followers View post →
Ian Chou
@IanChou10 · X

RT @AgingBiology: Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional…

Aug 31, 2020 · 4 shares · 156 followers View post →
Agingdoc
@agingdoc1 · X

Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity This replicated earlier work, also by Nir, supporting the dominance of longevity assurance genes in overcoming risk factors. https://t.co/tJNOpIwFLu

Aug 31, 2020 · 41,947 followers View post →
Rachel Harris
@Harris5Rach · X

Exceptional lifespan and healthspan are not attributable to a relative depletion of pathogenic gene variants. #FDSC898 https://t.co/gUGj0OAbSj

Aug 30, 2020 · 12 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional longevity https://t.co/0fHTpb2YDC

Aug 30, 2020 · 2 likes · 9,730 followers View post →
Jorge I. Castillo-Quan, MD, PhD
@CastilloQuan_JI · X

RT @AgingBiology: Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional…

Aug 30, 2020 · 4 shares · 2,054 followers View post →
Aging Science News
@AgingBiology · X

Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional longevity https://t.co/bVaVvgov57

Aug 30, 2020 · 8 likes · 4 shares · 30,819 followers View post →
Paperbirds_Neurology
@PaperbirdsN · X

New article: Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity. https://t.co/bq8t0C6P1w #alzheimers #neurology https://t.co/liMrMwd4h1

Aug 30, 2020 · 456 followers View post →
AD_papers
@ad_papers · X

Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity. Aging Cell #Alzheimers https://t.co/pmaHI9poTP

Aug 30, 2020 · 151 followers View post →