Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional #longevity. #genetics #SNPs #polymorphism https://t.co/6xpFZp7BPK https://t.co/MOixH0Z2HG
Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity.
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Aug 2020 – Apr 2025Where it's discussed
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X / Twitter23 posts
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News18 articles
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Blogs4 articles
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YouTube2 videos
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Facebook2 posts
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Reddit2 posts
AI synopsis
What people are saying
Discussions reflect a high level of interest and engagement, with posts highlighting key insights like the lack of fewer mutations in long-lived individuals, paralleling past studies and emphasizing the need to explore other genetic or lifestyle factors. Phrases such as 'supporting the dominance of longevity genes' and references to implications for aging research showcase a thoughtful and impactful dialogue surrounding the publication.
Most discussions acknowledge and support the findings that longevity isn't solely determined by having fewer harmful genetic variants, often referencing previous research and reinforcing the study's conclusions.
The talks demonstrate high curiosity about the genetics of longevity and aging, with many posts emphasizing the implications for understanding health in old age.
Participants reference specific aspects of the research, such as the similar mutation burdens and the role of other factors, indicating deep engagement with the content.
The discourse suggests the findings could influence future research directions in aging genetics and challenge traditional views about genetic mutation burdens contributing to longevity.
Abstract in brief
- Centenarians show a surprising longevity and health despite having similar genetic mutation burdens compared to their peers, revealed through whole exome sequencing of 1,879 individuals, including ELLI, their offspring, and controls.
- Analyses found no significant differences in the types or frequencies of harmful genetic variants between centenarians and non-centenarian controls, indicating that being a centenarian is not linked to having fewer harmful mutations.
- Notably, ELLI displayed a lower presence of cancer and Alzheimer’s-associated variants, hinting that their longevity may be influenced by other genomic or lifestyle factors rather than simply a lack of harmful mutations.
Top posts
Most liked on X and BlueskySimilar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional longevity https://t.co/bVaVvgov57
@adamgries @NobleDenis https://t.co/fELzcYFrP2
Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional longevity https://t.co/0fHTpb2YDC
RT @Prof_M_Ristow: Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional…
Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity This replicated earlier work, also by Nir, supporting the dominance of longevity assurance genes in overcoming risk factors. https://t.co/tJNOpIwFLu
All mentions
Recent Advances in Longevity and Aging Research
In this video, I explore the latest developments in the science of longevity. Covering topics like the potential lifespan-extending benefits of AKG, muscle response to resistance training in older individuals, and the…
Centenarians Carry Similar Pathogenic Mutations as Others
Centenarians show remarkable longevity despite having a similar burden of harmful genetic mutations as their peers, indicating other factors contribute to their extended lifespan, according to recent genetic studies.
RT @Madam_Mito: @adamgries @NobleDenis https://t.co/fELzcYFrP2
RT @Madam_Mito: @adamgries @NobleDenis https://t.co/fELzcYFrP2
@adamgries @NobleDenis https://t.co/fELzcYFrP2
LONGEVITY & AGING NEWS | Anti-aging In The News https://t.co/01WrWB9CO1 via @YouTube
Longevity and aging news Lance Hitchens https://t.co/E1CC2qXhLY
https://t.co/d6WVzCLgvx
RT @Prof_M_Ristow: Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional…
RT @Prof_M_Ristow: Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional…
RT @Prof_M_Ristow: Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional…
RT @Prof_M_Ristow: Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional…
RT @Prof_M_Ristow: Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional…
Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional #longevity. #genetics #SNPs #polymorphism https://t.co/6xpFZp7BPK https://t.co/MOixH0Z2HG
Check out "Centenarians do not carry fewer pathogenic mutations | Lifespan News" at: https://t.co/zOMqqIyws7
Long Lived Humans Do Not Exhibit Fewer Harmful Gene Variants. https://t.co/RH57WVtohQ
RT @AgingBiology: Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional…
RT @AgingBiology: Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional…
Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity This replicated earlier work, also by Nir, supporting the dominance of longevity assurance genes in overcoming risk factors. https://t.co/tJNOpIwFLu
Exceptional lifespan and healthspan are not attributable to a relative depletion of pathogenic gene variants. #FDSC898 https://t.co/gUGj0OAbSj
Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional longevity https://t.co/0fHTpb2YDC
RT @AgingBiology: Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional…
Similar burden of pathogenic coding variants in exceptionally long‐lived individuals and individuals without exceptional longevity https://t.co/bVaVvgov57
New article: Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity. https://t.co/bq8t0C6P1w #alzheimers #neurology https://t.co/liMrMwd4h1
Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity. Aging Cell #Alzheimers https://t.co/pmaHI9poTP
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